Sex modulates the arrhythmogenic substrate in prepubertal rabbit hearts with long QT 2

Journal of Cardiovascular Electrophysiology

Volumn 16, Issue 5, 2005, Pages 516-524

  Liu, Tong ^a   Choi, Bum Rak ^a   Drici, Milou Daniel ^a   Salama, Guy ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Arrhythmia; Gender; Ion channels; Long QT syndrome; Mapping

Indexed keywords

ISOPRENALINE; PROPRANOLOL;

ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ECHOCARDIOGRAPHY; FEMALE; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE TACHYCARDIA; LONG QT SYNDROME; MALE; NONHUMAN; PREPUBERTY; PRIORITY JOURNAL; RABBIT; SEX DIFFERENCE; TORSADE DES POINTES;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; DISEASE MODELS, ANIMAL; FEMALE; ISOPROTERENOL; LONG QT SYNDROME; MALE; RABBITS; SEX FACTORS; STATISTICS, NONPARAMETRIC; TORSADES DE POINTES;

EID: 18244380076     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1540-8167.2005.40622.x     Document Type: Article

References (43)

1. Roden DM, Lazzara R, Rosen M, Schwartz PJ, Towbin J, Vincent GM: Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS. Circulation 1996;94:1996-2012.
2. Vincent GM: Long QT syndrome. Cardiol Clin 2000;18:309-325.
3. Vincent GM: The molecular genetics of the long QT syndrome: Genes causing fainting and sudden death. Annu Rev Med 1998;49:263-274.
4. Napolitano C, Priori SG, Schwartz PJ: Torsade de pointes. Mechanisms and management. Drugs 1994;47:51-65.
5. Drici MD, Clement N: Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome. Drug Saf 2001;24:575-585.
6. Zeltser D, Justo D, Halkin A, Prokhorov V, Heller K, Viskin S: Torsade de pointes due to noncardiac drugs: Most patients have easily identifiable risk factors. Medicine (Baltimore) 2003;82:282-290.
7. Zareba W, Moss AJ, Locati EH, Lehmann MH, Peterson DR, Hall WJ, Schwartz PJ, Vincent GM, Priori SG, Benhorin J, Towbin JA, Robinson JL, Andrews ML, Napolitano C, Timothy K, Zhang L, Medina A: Modulating effects of age and gender on the clinical course of long QT syndrome by genotype. J Am Coll Cardiol 2003;42:103-109.
8. Ebert SN, Liu XK, Woosley RL: Female gender as a risk factor for drug-induced cardiac arrhythmias: Evaluation of clinical and experimental evidence. J Womens Health 1998;7:547-557.
9. Pham TV, Rosen MR: Sex, hormones, and repolarization. Cardiovasc Res 2002;53:740-751.
10. Zabel M, Hohnloser SH, Behrens S, Li YG, Woosley RL, Franz MR: Electrophysiologic features of torsades de pointes: Insights from a new isolated rabbit heart model. J Cardiovasc Electrophysiol 1997;8:1148-1158.
11. Eckardt L, Haverkamp W, Borggrefe M, Breithardt G: Experimental models of torsade de pointes. Cardiovasc Res 1998;39:178-193.
12. Carlsson L, Abrahamsson C, Andersson B, Duker G, Schiller-Linhardt G: Proarrhythmic effects of the class III agent almokalant: Importance of infusion rate, QT dispersion, and early afterdepolarisations. Cardiovasc Res 1993;27:2186-2193.
13. 2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome. J Physiol 2002;543:615-631.
14. Berger M, Corre M, Jean-Faucher C, De Turckheim M, Veyssiere G, Jean C: Changes in the testosterone to dihydrotestosterone ratio in plasma and testes of maturing rabbits. Endocrinology 1979;104:1450-1454.
15. de Turckheim M, Berger M, Jean-Faucher C, Veyssiere G, Jean C: Changes in ovarian oestrogens and in plasma gonadotrophins in female rabbits from birth to adulthood. Acta Endocrinol (Copenh) 1983;103:125-130.
16. Berger M, Jean-Faucher C, de Turckheim M, Veyssiere G, Blanc MR, Poirier JC, Jean C: Testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) in plasma of rabbit from birth to adulthood. Correlation with sexual and behavioural development. Acta Endocrinol (Copenh) 1982;99:459-465.
17. Efimov IR, Huang DT, Rendt JM, Salama G: Optical mapping of repolarization and refractoriness from intact hearts. Circulation 1994;90:1469-1480.
18. + current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 1990;96:195-215.
19. Shimizu W, Antzelevitch C: Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 2000;35:778-786.
20. Yamauchi S, Yamaki M, Watanabe T, Yuuki K, Kubota I, Tomoike H: Restitution properties and occurrence of ventricular arrhythmia in LQT2 type of long QT syndrome. J Cardiovasc Electrophysiol 2002;13:910-914.
21. Salama G, Lombardi R, Elson J: Maps of optical action potentials and NADH fluorescence in intact working hearts. Am J Physiol 1987;252:H384-H394.
22. Salama G, Kanai A, Efimov IR: Subthreshold stimulation of Purkinje fibers interrupts ventricular tachycardia in intact hearts. Experimental study with voltage-sensitive dyes and imaging techniques. Circ Res 1994;74:604-619.
23. Liu XK, Katchman A, Drici MD, Ebert SN, Ducic I, Morad M, Woosley RL: Gender difference in the cycle length-dependent QT and potassium currents in rabbits. J Pharmacol Exp Ther 1998;285:672-679.
24. Bazett H: An analysis of time relations of electrocardiograms. Heart 1920;7:353.
25. Liu XK, Katchman A, Whitfield BH, Wan G, Janowski EM, Woosley RL, Ebert SN: In vivo androgen treatment shortens the QT interval and increases the densities of inward and delayed rectifier potassium currents in orchiectomized male rabbits. Cardiovasc Res 2003;57:28-36.
26. Rautaharju PM, Zhou SH, Wong S, Calhoun HP, Berenson GS, Prineas R, Davignon A: Sex differences in the evolution of the electrocardiographic QT interval with age. Can J Cardiol 1992;8:690-695.
27. Larsen JA, Tung RH, Sadananda R, Goldberger JJ, Horvath G, Parker MA, Kadish AH: Effects of hormone replacement therapy on QT interval. Am J Cardiol 1998;82:993-995.
28. Bidoggia H, Maciel JP, Capalozza N, Mosca S, Blaksley EJ, Valverde E, Bertran G, Arini P, Biagetti MO, Quinteiro RA: Sex differences on the electrocardiographic pattern of cardiac repolarization: Possible role of testosterone. Am Heart J 2000;140:678-683.
29. Stolt A, Karila T, Viitasalo M, Mantysaari M, Kujala UM, Karjalainen J: QT interval and QT dispersion in endurance athletes and in power athletes using large doses of anabolic steroids. Am J Cardiol 1999;84:364-6, A9.
30. Kanai A, Salama G: Optical mapping reveals that repolarization spreads anisotropically and is guided by fiber orientation in guinea pig hearts. Circ Res 1995;77:784-802.
31. Baker LC, London B, Choi BR, Koren G, Salama G: Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia. Circ Res 2000;86:396-407.
32. + current: A potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents. Cardiovasc Res 1999;43:135-147.
33. Viskin S: Long QT syndromes and torsade de pointes. Lancet 1999;354:1625-1633.
34. 2+ current. Circ Res 1989;64:977-990.
35. (+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome. Circulation 2000;102:706-712.
36. Klangkalya B, Chan A: The effects of ovarian hormones on beta-adrenergic and muscarinic receptors in rat heart. Life Sci 1988;42:2307-2314.
37. Locati EH, Zareba W, Moss AJ, Schwartz PJ, Vincent GM, Lehmann MH, Towbin JA, Priori SG, Napolitano C, Robinson JL, Andrews M, Timothy K, Hall WJ: Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: Findings from the International LQTS Registry. Circulation 1998;97:2237-2244.
38. Liu T, Choi B-R, Salama G: Gender differences in the vulnerability to E4031-induced arrhythmias, in pre-pubertal versus adult rabbit hearts. Circulation 2002;106:II-303.
39. Restivo M, Caref EB, Kozhevnikov DO, El-Sherif N: Spatial dispersion of repolarization is a key factor in the arrhythmogenicity of long QT syndrome. J Cardiovasc Electrophysiol 2004;15:323-331.
40. 2+ transients in a rabbit model of LQT3: Role of Cai handling in the initiation of early afterdepolarizations and arrhythmias. Circ Suppl 2001;104:515.
41. 2+ currents induced by endothelin-1 in guinea pig papillary muscles and ventricular myocytes. Methods Find Exp Clin Pharmacol 1997;19:19-25.
42. Verduyn SC, Vos MA, van der Zande J, van der Hulst FF, Wellens HJ: Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: Reversal by magnesium. Cardiovasc Res 1997;34:453-463.
43. Day CP, McComb JM, Campbell RW: QT dispersion: An indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990;63:342-344.