Drugs for men and women - How important is gender as a risk factor for TdP?

Pharmacology and Therapeutics

Volumn 119, Issue 2, 2008, Pages 186-194

  Coker, Susan J ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Arrhythmias; Estrogen; Gender; Sex hormones; Testosterone; Torsade de pointes

Indexed keywords

AMIODARONE; ANDROSTANOLONE; ASTEMIZOLE; BEPRIDIL; CISAPRIDE; CLARITHROMYCIN; CLOFILIUM; CONJUGATED ESTROGEN; DISOPYRAMIDE; DOFETILIDE; ERYTHROMYCIN; ESTRADIOL; HALOFANTRINE; HALOPERIDOL; IBUTILIDE; ISOPRENALINE; KETANSERIN; MEDROXYPROGESTERONE ACETATE; PENTAMIDINE; PRENYLAMINE; PROBUCOL; PROCAINAMIDE; PROGESTERONE; QUINIDINE; SEX HORMONE; SOTALOL; TERFENADINE; TERODILINE; THIORIDAZINE; UNINDEXED DRUG;

ACTION POTENTIAL; CALCIUM CURRENT; CLINICAL TRIAL; DISEASE PREDISPOSITION; GENDER; HEART REPOLARIZATION; HEART VENTRICLE TACHYCARDIA; HUMAN; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; QT PROLONGATION; REVIEW; RISK BENEFIT ANALYSIS; RISK FACTOR; SEX DIFFERENCE; TORSADE DES POINTES;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG DESIGN; ELECTROPHYSIOLOGY; FEMALE; GONADAL STEROID HORMONES; HUMANS; LONG QT SYNDROME; MALE; PHARMACEUTICAL PREPARATIONS; RISK FACTORS; SEX CHARACTERISTICS; TORSADES DE POINTES;

EID: 50049093214     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2008.03.005     Document Type: Review

References (61)

1. Abdelgadir S.E., Resko J.A., Ojeda S.R., Lephart E.D., McPhaul M.J., and Roselli C.E. Androgens regulate aromatase cytochrome P450 messenger ribonucleic acid in rat brain. Endocrinology 135 (1994) 395-401
2. Abi-Gerges N., Philp K., Pollard C., Wakefield I., Hammond T.G., and Valentin J.P. Sex differences in ventricular repolarization: from cardiac electrophysiology to torsades de pointes. Fundam Clin Pharmacol 18 (2004) 139-151
3. Ks, ß-adrenoceptor stimulation, pacing rate and gender. Br J Pharmacol 147 (2006) 653-660
4. Adams M.R., Register T.C., Golden D.L., Wagner J.D., and Williams J.K. Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis. Arterioscler Thromb Vasc Biol 17 (1997) 217-221
5. Bai C.X., Kurokawa J., Tamagawa M., Nakaya H., and Furukawa T. Nontranscriptional regulation of cardiac repolarization currents by testosterone. Circulation 112 (2005) 1701-1710
6. Bednar M.M., Harrigan E.P., and Ruskin J.N. Torsades de pointes associated with nonantiarrhythmic drugs and observations on gender and QTc. Am J Cardiol 89 (2002) 1316-1319
7. Bidoggia H., Maciel J.P., Capalozza N., Mosca S., Blaksley E.J., Valverde E., et al. Sex differences on the electrocardiographic pattern of cardiac repolarization: possible role of testosterone. Am Heart J 140 (2000) 678-683
8. Booker P.D., Whyte S.D., and Ladusans E.J. Long QT syndrome and anaesthesia. Br J Anaesth 90 (2003) 349-366
9. Brouillette J., Lupien M.-A., St-Michel C., and Fiset C. Characterization of ventricular repolarization in male and female guinea pigs. J Mol Cell Cardiol 42 (2007) 357-366
10. Brouillette J., Lupien M.-A., St-Michel C., and Fiset C. Corrigendum to "Characterization of ventricular repolarization in male and female guinea pigs" [J. Mol. Cell. Cardiol. 42 (2007) 357-366]. J Mol Cell Cardiol 44 (2008) 451
11. Burke M.D., Ehlert M.D., Kruse R.N., and Parker R.N. Gender-specific differences in the QT interval and the effect of autonomic tone and menstrual cycle in healthy adults. Am J Cardiol 79 (1997) 178-181
12. Carlsson L., Almgren O., and Duker G. QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions. J Cardiovasc Pharmacol 16 (1990) 276-285
13. ++ overload. J Pharmacol Exp Ther 279 (1996) 231-239
14. Chen Y.J., Lee S.H., Hsieh M.H., Hsiao C.J., Yu W.C., Chiou C.W., et al. Effects of 17 beta-estradiol on tachycardia-induced changes of atrial refractoriness and cisapride-induced ventricular arrhythmia. J Cardiovasc Electrophysiol 10 (1999) 587-598
15. Cheng J. Evidences of the gender-related differences in cardiac repolarization and the underlying mechanisms in different animal species and human. Fundam Clin Pharmacol 20 (2006) 1-8
16. Cheng C.-F., Kuo H.-C., and Chien K.R. Genetic modifiers of cardiac arrhythmias. Trends Mol Med 9 (2003) 59-66
17. Dhote V.V., and Balaraman R. Gender specific effect of progesterone on myocardial ischemia/reperfusion injury in rats. Life Sci 81 (2007) 188-197
18. Drici M.D., Knollmann B.C., Wang W.X., and Woosley R.L. Cardiac actions of erythromycin: influence of female sex. JAMA 280 (1998) 1774-1776
19. 2+ sparks: acute actions antagonize chronic effects. Cell Calcium 41 (2007) 467-477
20. Fulop L., Banyasz T., Szabo G., Toth I.B., Biro T., Lorincz I., et al. Effects of sex hormones on ECG parameters and expression of cardiac ion channels in dogs. Acta Physiol (Oxf) 188 (2006) 163-171
21. Furukawa T., and Kurokawa J. Regulation of cardiac ion channels via non-genomic action of sex steroid hormones: implication for the gender difference in cardiac arrhythmias. Pharmacol Ther 115 (2007) 106-115
22. Gokce M., Karahan B., Yilmaz R., Orem C., Erdol C., and Ozdemir S. Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhytmia. Int J Cardiol 99 (2005) 373-379
23. Hara M., Danilo Jr. P., and Rosen M.R. Effects of gonadal steroids on ventricular repolarization and on the response to E4031. J Pharmacol Exp Ther 285 (1998) 1068-1072
24. Hulot J.-S., Demolis J.-L., Riviere R., Strabach S., Christin-Maitre S., and Funck-Brentano C. Influence of endogenous oestrogens on QT interval duration. Eur Heart J 24 (2003) 1663-1667
25. James A.F., Arberry L.A., and Hancox J.C. Gender-related differences in ventricular myocyte repolarization in the guinea pig. Basic Res Cardiol 99 (2004) 183-192
26. James A.F., Choisy S.C.M., and Hancox J.C. Recent advances in understanding sex differences in cardiac repolarization. Prog Biophys Mol Biol 94 (2007) 265-319
27. Johansson M., and Carlsson L. Female gender does not influence the magnitude of ibutilide-induced repolarization delay and incidence of torsades de pointes in an in vivo rabbit model of the acquired long QT syndrome. J Cardiovasc Pharmacol Ther 6 (2001) 247-254
28. Katzung B. "Basic and clinical pharmacology". 7th edition Appleton & Lange, Stamford, Conneticut (1998)
29. Larsen J.A., Tung R.H., Sadananda R., Goldberger J.J., Horvath G., Parker M.A., et al. Effects of hormone replacement therapy on QT interval. Am J Cardiol 82 (1998) 993-995
30. Lehmann M.H., Hardy S., Archibald D., Quart B., and Macneil D.J. Sex difference in risk of torsade de pointes with d,l-sotalol. Circulation 94 (1996) 2535-2541
31. Levine R., Chen S., Durand J., Chen Y., and Oparil S. Medroxyprogesterone attenuates estrogen-mediated inhibition of neo-intima formation after balloon injury of the rat carotid artery. Circulation 94 (1996) 2221-2227
32. Liu X.K., Wang W., Ebert S.N., Franz M.R., Katchman A., and Woosley R.L. Female gender is a risk factor for torsades de pointes in an in vitro animal model. J Cardiovasc Pharmacol 34 (1999) 287-294
33. Liu X.K., Katchman A., Drici M.D., Ebert S.N., Ducic I., Morad M., et al. Gender difference in the cycle length-dependent QT and potassium currents in rabbits. J Pharmacol Exp Ther 285 (1998) 672-679
34. Locati E.H., Zareba W., Moss A.J., Schwartz P.J., Vincent G.M., Lehmann M.H., et al. Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: findings from the International LQTS Registry. Circulation 97 (1998) 2237-2244
35. Lu H.R., Marien R., Saels A., and De Clerck F. Are there sex-specific differences in ventricular repolarization or in drug-induced early afterdepolarizations in isolated rabbit Purkinje fibers?. J Cardiovasc Pharmacol 36 (2000) 132-139
36. Lu H.R., Remeysen P., Somers K., Saels A., and De Clerck F. Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model. J Cardiovasc Electrophysiol 12 (2001) 538-545
37. Makkar R.R., Fromm B.S., Steinman R.T., Meissner M.D., and Lehmann M.H. Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. JAMA 270 (1993) 2590-2597
38. Moller C., and Netzer R. Effects of estradiol on cardiac ion channel currents. Eur J Pharmacol 532 (2006) 44-49
39. Nakagawa M., Ooie T., Takahashi N., Taniguchi Y., Anan F., Yonemochi H., et al. Influence of menstrual cycle on QT interval dynamics. Pacing Clin Electrophysiol 29 (2006) 607-613
40. Nowinski K., Pripp U., Carlstrom K., Landgren B.M., Schenck-Gustafsson K., and Bergfeldt L. Repolarization measures and their relation to sex hormones in postmenopausal women with cardiovascular disease receiving hormone replacement therapy. Am J Cardiol 90 (2002) 1050-1055
41. Pham T.V., and Rosen M.R. Sex, hormones, and repolarization. Cardiovasc Res 53 (2002) 740-751
42. K-blocking drugs. Circulation 103 (2001) 2207-2212
43. Pham T.V., Robinson R.B., Danilo J., Peter, and Rosen M.R. Effects of gonadal steroids on gender-related differences in transmural dispersion of L-type calcium current. Cardiovasc Res 53 (2002) 752-762
44. Pham T.V., Sosunov E.A., Anyukhovsky E.P., Danilo Jr. P., and Rosen M.R. Testosterone diminishes the proarrhythmic effects of dofetilide in normal female rabbits. Circulation 106 (2002) 2132-2136
45. Philp K.L., Hart G., and Coker S.J. A gender-independent proarrhythmic action of 17ß-estradiol in anaesthetized rabbits. Eur J Pharmacol 575 (2007) 113-121
46. 2+ channel blockade. Br J Pharmacol 149 (2006) 233-242
47. Rodriguez I., Kilborn M.J., Liu X.K., Pezzullo J.C., and Woosley R.L. Drug-induced QT prolongation in women during the menstrual cycle. JAMA 285 (2001) 1322-1326
48. Ruan Y.F., Liu N., Zhou Q., Li Y., and Wang L. Experimental study on the mechanism of sex difference in the risk of torsade de pointes. Chinese Med J 117 (2004) 538-541
49. Saba S., Link M.S., Homoud M.K., Wang P.J., and Estes N.A.M. Effect of low estrogen states in healthy women on dispersion of ventricular repolarization. Am J Cardiol 87 (2001) 354+
50. Sbarouni E., Zarvalis E., Kyriakides Z.S., and Kremastinos D.T. Absence of effects of short-term estrogen replacement therapy on resting and exertional QT and QTc dispersion in postmenopausal women with coronary artery disease. Pacing Clin Electrophysiol 21 (1998) 2392-2395
51. Schwartz P.J., Priori S.G., Spazzolini C., Moss A.J., Vincent G.M., Napolitano C., et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 103 (2001) 89-95
52. Shaw L., Taggart M., and Austin C. Effects of the oestrous cycle and gender on acute vasodilatory responses of isolated pressurized rat mesenteric arteries to 17 ß-oestradiol. Br J Pharmacol 132 (2001) 1055-1062
53. Shuba Y.M., Degtiar V.E., Osipenko V.N., Naidenov V.G., and Woosley R.L. Testosterone-mediated modulation of HERG blockade by proarrhythmic agents. Biochem Pharmacol 62 (2001) 41-49
54. Splawski I., Shen J.X., Timothy K.W., Lehmann M.H., Priori S., Robinson J.L., et al. Spectrum of mutations in long-QT syndrome genes KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 102 (2000) 1178-1185
55. Tanabe S., Hata T., and Hiraoka M. Effects of estrogen on action potential and membrane currents in guinea pig ventricular myocytes. Am J Physiol 277 (1999) H826-H833
56. Thum T., and Borlak J. Testosterone, cytochrome P450, and cardiac hypertrophy. FASEB J 16 (2002) 1537-1549
57. Valverde E.R., Biagetti M.O., Bertran G.R., Arini P.D., Bidoggia H., and Quinteiro R.A. Developmental changes of cardiac repolarization in rabbits: implications for the role of sex hormones. Cardiovasc Res 57 (2003) 625-631
58. Vos M.A., Verduyn S.C., Gorgels A.P.M., Lipcsei G.C., and Wellens H.J.J. Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation 91 (1995) 864-872
59. Weissenburger J., Davy J., Chezalviel F., Ertzbischoff O., Poirier J., Engel F., et al. Arrhythmogenic activities of antiarrhythmic drugs in conscious hypokalemic dogs with atrioventricular block: comparison between quinidine, lidocaine, flecainide, propranolol and sotalol. J Pharmacol Exp Ther 259 (1991) 871-883
60. Yildirir A., Aybar F., Kabakci M.G., Yarali H., Akgul E., Bukulmez O., et al. Hormone replacement therapy shortens QT dispersion in healthy postmenopausal women. Ann Noninvasive Electrocardiol 6 (2001) 193-197
61. Zareba W., Moss A.J., Schwartz P.J., Vincent G.M., Robinson J.L., Priori S.G., et al. Influence of genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group. New Engl J Med 339 (1998) 960-965