Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo

Environmental Toxicology and Pharmacology

Volumn 26, Issue 1, 2008, Pages 80-85

  Pillai, Thulasi G ^a   Nair, Cherupally Krishnan Krishnan ^a   Janardhanan, K K ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Ganoderma lucidum; Lipid peroxidation; Micronucleus assay; pBR 322; Polysaccharides; Radioprotection

Indexed keywords

AMIFOSTINE; GANODERMA LUCIDUM EXTRACT; POLYSACCHARIDE; RADIOPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG MECHANISM; ERYTHROCYTE; GAMMA RADIATION; GANODERMA LUCIDUM; IN VITRO STUDY; IN VIVO STUDY; INDIA; LIPID PEROXIDATION; MALE; MEMBRANE DAMAGE; MICRONUCLEI IN POLYCHROMATIC ERYTHROCYTE; MICRONUCLEUS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION PROTECTION; RETICULOCYTE; SINGLE DRUG DOSE; SURVIVAL RATE; SWISS ALBINO MICE;

ANIMALIA; GANODERMA; GANODERMA LUCIDUM; MUS;

EID: 42149124430     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2008.02.004     Document Type: Article

References (28)

1. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
2. Beuge J.A., and Aust S.D. Microsomal lipid peroxidation. Meth. Enzymol. 52 (1978) 302-310
3. Craig II B., and Alt F.W. The cellular response to general and programmed DNA double strad breaks. DNA Repair 3 (2004) 781-796
4. Devita V.T. Cancer: Principles and Practice of Oncology (1997), Lippincott-Raven, Philadelphia pp. 3087-3092
5. Dubois S.M., Gilles G.A., and Hamilton J.K. Colourimetric estimation of carbohydrates by phenol sulphuric acid method. Anal. Chem. 28 (1956) 350-356
6. Gao Y.H., Zhou S.H., Jiang W.Q., Huang M., and Dai X.H. Effect of Ganopoly, a G. lucidum polysaccharide extract on the immunological function in advanced-stage cancer patents. Immunol. Invest. 32 (2003) 201-215
7. Gao Y., Wenbo T., Gao H., Lan T., and Zhou S. Chemopreventive and tumoricidal propaerties of Ling Zhi mushroom G. lucidum. Preclinical and clinical studies. Int. J. Med. Mushrooms 4 (2004) 95-106
8. Gandhi N.M., Gopapaswamy U.V., and Nair C.K.K. Radiation protection by Disulfiram. J. Radiat. Res. 44 (2003) 265-269
9. Hahn S.M., Krishna M.C., Samuni A., Degraff W., Cuscela D.O., Johnstone P., and Mitchell J.B. Potential use of nitroxides in radiation oncology. Cancer Res. 54 (1994) 2006-2010
10. Hanawalt P.C., Cooper P.C., Ganesan A.K., and Smith K.C. DNA repair in bacteria and mammalian cells. Annu. Rev. Biochem. 4 (1979) 783-836
11. Hamasu T., Inanami O., Asanuma T., and Kuwabara M. Enhanced induction of apoptosis by combined treatment of human carcinoma cells with X-rays and death receptors agonists. J. Radiat. Res. 46 (2005) 103-110
12. Hofer M., Mazur L., Pospisil M., Weiterova L., and Znojil V. Radioprotective action of extracellular adenosine on bone marrow cells in mice exposed to γ-rays as assayed by the micronucleus test. Radiat. Res. 154 (2000) 217
13. Maurya D.K., Salvi V.P., and Nair C.K.K. Radioprotection of normal tissues in tumour-bearing mice by troxerutin. J. Radiat. Res. 45 (2004) 221-228
14. Mizuno T. Development of an antitumor biological response modifier from Phellinus linteus (Berk et curt) Teng (Aphyllophoromycetidae). Int. J. Med. Mushrooms 2 (2000) 21-33
15. Maurya D.K., and Nair C.K.K. Preferential radioprotection to DNA of normal tissues by ferulic acid under ex vivo and in vivo conditions in tumor bearing mice. Mol. Cell. Biochem. 285 (2006) 181-190
16. Nayak V., and Umadevi P. Protection of mouse bone marrow against radiation-induced chromosome damage and stem cell death by the Ocimum flavanoids orientin and vicenin. Radiat. Res. 162 (2005) 165-171
17. Pasupathy K., Nair C.K.K., and Kagiya T.V. Effect of a hypoxic radiosensitizer Ak 2123 (Sanazole) on yeast Saccharomyces cerevisiae. J. Radiat. Res. 42 (2001) 217-227
18. Pillai T.G., Salvi V.P., Maurya D.K., Nair C.K.K., and Janardhanan K.K. Prevention of radiation induced damages by aqueous extract of Ganoderma lucidum occurring in Southern parts of India. Curr. Sci. 91 (2006) 341-344
19. Rajesh A., Damodar G.R.C., Ravinder S., Ashok S., Raj K., Jagdish P., Surinder S., Namita S., and Rakesh K.S. Radioprotection by plant products: present status and future prospects. Phytother. Res. 19 (2005) 1-22
20. Shi J.H. PSP for the protection of the tumor patients during chemotherapy. In: Yang Q.Y., and Kwok C.Y. (Eds). PSP International Symposium (1993), Fudan U, Press, Shanghai 271-272
21. Schmidt-Ullrich R.K., Dent P., Grant S., Mikkelsen R.B., and Valerie K. Signal transduction and cellular radiation responses. Radiat. Res. 153 (2000) 245-257
22. Shaw L., Glover D., and Turrisi A. Pharmacokinetics of amifostine. Pharmacol. Ther. (1988) 195-201
23. Schmid W. The micronucleus test. Mutat. Res. 31 (1975) 9-15
24. Shety T.K., Satav J.G., and Nair C.K.K. Protection of DNA and microsomal membranes in vitro by Glycyrrhizia glabra L., against gamma irradiation. Phytother. Res. 16 (2002) 576-578
25. Staub A.M. Removal of protein. Sevag method. Methods Carbohydr. Chem. 5 (1969) 5-6
26. Tohamy A.A., EI-Ghor A.A., EI-Nahas S.M., and Noshy M.M. β-Glucan inhibits the genotoxicity of cyclophosphamide, adriamycin and cisplatin. Mutat. Res. 541 (2003) 45-53
27. Wasser S.P. Reishi or Ling Zhi (Ganoderma lucidum). In: Coates P.M., Blackman M.R., Cragg G.M., Levine M., Moss J., and White J.D. (Eds). Encyclopedia of Dietary (2005), Marcel Dekker, NY, USA 603-622
28. Yemn E.W., and Wills A.J. The estimation of carbohydrate in plant extract by Anthrone. Biochem. J. 57 (1954) 508-514