Function of cardiac β1- and β2-adrenoceptors of newborn piglets: Role of phosphodiesterases PDE3 and PDE4

European Journal of Pharmacology

Volumn 638, Issue 1-3, 2010, Pages 99-107

  Galindo Tovar, Alejandro ^a   Vargas, Maria Luisa ^a   Kaumann, Alberto J ^b  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

1 adrenoceptor; 2 adrenoceptor; CAMP (cyclic adenosine monophosphate); Noradrenaline and adrenaline; Phosphodiesterase3; Phosphodiesterase4; Piglet heart; Sinoatrial tachycardia and contractile force

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ADRENALIN; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CILOSTAMIDE; NORADRENALIN; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV; ROLIPRAM; ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLIC AMP; PHOSPHODIESTERASE INHIBITOR; QUINOLONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART LEFT ATRIUM; HEART RIGHT VENTRICLE; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; SINUS NODE; SINUS TACHYCARDIA; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; HEART ATRIUM; HEART VENTRICLE; IN VITRO STUDY; METABOLISM; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY; SWINE; TACHYCARDIA;

ADRENERGIC AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANIMALS, NEWBORN; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; EPINEPHRINE; HEART ATRIA; HEART VENTRICLES; NOREPINEPHRINE; PHOSPHODIESTERASE INHIBITORS; QUINOLONES; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; ROLIPRAM; SINOATRIAL NODE; SWINE; TACHYCARDIA;

EID: 77953535360     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.04.013     Document Type: Article

References (31)

1. 3-adrenoceptors. Br. J. Pharmacol. 2005, 144:317-322.
2. Baker J.G., Hall I.P., Hill S.J. Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses. Mol. Pharmacol. 2003, 64:679-688.
3. 4 mRNA in heart failure. Naunyn-Schmiedeberg's Arch. Pharmacol. 2004, 370:157-166.
4. Buxton B.F., Jones C.R., Molenaar P., Summers R.J. Characterization and autoradiographic localization of beta-adrenoceptor subtypes in human cardiac tissues. Br. J. Pharmacol. 1987, 92:299-310.
5. Chong L.K., Chess-Williams R., Peachell P.T. Pharmacological characterisation of the β-adrenoceptor expressed by human lung mast cells. Eur. J. Pharmacol. 2002, 437:1-7.
6. 2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart. Br. J. Pharmacol. 2009, 156:62-83.
7. Fischmeister R., Castro L.R.V., Abi-Gerges A., Rochais F., Jurevicius J., Leroy J., Vandecasteele G. Compartmentation of cyclic nucleotide signalling in the heart. The role of cyclic nucleotide phosphodiesterases. Circ. Res. 2006, 99:816-828.
8. 1-adrenoceptors. Br. J. Pharmacol. 2008, 153:710-720.
9. 4 receptors. Br. J. Pharmacol. 2009, 156:237-249.
10. Galindo-Tovar A., Vargas M.L., Kaumann A.J. Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium. Naunyn-Schmiedeberg's Arch. Pharmacol. 2009, 379:379-384.
11. 2-adrenoceptors of human heart. Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline. Naunyn-Schmiedeberg's Arch. Pharmacol. 1985, 331:60-70.
12. 2-adrenoceptor. Cardiovasc. Res. 1999, 42:173-182.
13. Hoffmann C., Leitz M.R., Oberdorf-Maass S., Lohse M.J., Klotz K.N. Comparative pharmacology of human β-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 2004, 369:151-159.
14. Houslay M.D. Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown. Trends Biochem. Sci. 2009, 35:91-100.
15. Katano Y., Endoh M. Effects of a cardiotonic quinolinone derivative Y-20487 on the positive inotropic action and cyclic AMP accumulation in rat ventricular myocardium: comparison with rolipram, Ro 20-1724, milrinone, and isobutylmethylxanthine. Cardiovasc. Pharmacol. 1992, 20:715-722.
16. 4-like receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 1990, 342:619-622.
17. 2-Adrenoceptor-mediated positive inotropic effect of adrenaline in human ventricular myocardium. Quantitative discrepancies with binding and adenylate cyclase stimulation. Naunyn-Schmiedeberg's Arch. Pharmacol. 1987, 335:403-411.
18. 4 receptor population in piglet atrium: functional relevance. Br. J. Pharmacol. 1995, 115:933-936.
19. 1-adrenoceptor-mediated sinoatrial tachycardia: evidence with PDE3 and PDE4 in rabbits and PDE1-5 in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 2009, 380:421-430.
20. 2-adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (-)-atenolol. Br. J. Pharmacol. 1988, 95:55-66.
21. 2-adrenergic receptor. J. Anim. Sci. 2001, 79:877-883.
22. Liang W., Bidwell C.A., Williams S.K., Mills S.E. Rapid communication: molecular cloning of the porcine beta2-adrenergic receptor gene. J. Anim. Sci. 1997, 75:2824.
23. MacKenzie S.J., Baillie G.S., MacPhee I., MacKenzie C., Seamons R., McSorley T., Millen J., Beard M.B., van Heeke G., Houslay M.D. Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in upstream conserved region 1 (UCR1). Br. J. Pharmacol 2002, 136:421-433.
24. McNeel R.L., Mersmann H.J. Distribution and quantification of beta1, beta2-, and beta3-adrenergic receptor subtype transcripts in porcine tissues. J. Anim. Sci. 1999, 77:611-621.
25. 1-adrenergic receptor mediated signalling. Circ. Res. 2006, 99:1084-1091.
26. 4 receptors by SB203186. Naunyn-Schmiedeberg's Arch. Pharmacol. 1995, 335:28-35.
27. 2-adrenergic receptors in heart, skeletal muscle, and adipose tissue, and the identification of an atypical β-adrenergic binding site. J. Anim. Sci. 2005, 83:2339-2348.
28. Vargas M.L., Hernandez J., Kaumann A.J. Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle. Br. J. Pharmacol. 2006, 147:158-163.
29. 2+ current in rat ventricular myocytes. Br. J. Pharmacol. 1999, 127:63-74.
30. Wiechelman K.J., Braun R.D., Fitzpatrick J.D. Investigation of the bicinchoninic acid protein assay: identification of the groups responsible for colour formation. Anal. Biochem. 1988, 175:231-237.
31. Yamanishi T., Chapple C.R., Yasuda K., Yoshida K., Chess-Williams R. The functional role of beta-adrenoceptor subtypes in mediating relaxation of pig urethral smooth muscle. J. Urol. 2003, 170:2508-2511.