Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 379, Issue 4, 2009, Pages 379-384

  Galindo Tovar, Alejandro ^a   Vargas, Maria Luisa ^a   Kaumann, Alberto J ^b  

^a UNIVERSITY OF MURCIA   (Spain)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

( ) CGP12177; Cilostamide and rolipram; Contractile force; Phosphodiesterases PDE3 and PDE4; Rat atrial 1 adrenoceptors; Sinoatrial tachycardia

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; BETA 1 ADRENERGIC RECEPTOR; CILOSTAMIDE; CYCLIC AMP; ISOPRENALINE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IV; ROLIPRAM;

ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CHRONOTROPISM; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; ENZYME ACTIVITY; HEART ATRIUM CONTRACTILITY; HEART RATE; HYDROLYSIS; INOTROPISM; NONHUMAN; RAT; SINOATRIAL CONDUCTION;

ADRENERGIC BETA-AGONISTS; ANIMALS; ARRHYTHMIA, SINUS; ATRIAL FUNCTION, LEFT; ATRIAL FUNCTION, RIGHT; BRADYCARDIA; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DRUG PARTIAL AGONISM; FEMALE; HEART ATRIA; HEART RATE; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; PHOSPHODIESTERASE INHIBITORS; PROPANOLAMINES; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-1; ROLIPRAM; STIMULATION, CHEMICAL; TACHYCARDIA;

EID: 60849083800     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0367-7     Document Type: Article

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