Inotropy and L-type Ca 2+ current, activated by β 1- and β 2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart

British Journal of Pharmacology

Volumn 156, Issue 1, 2009, Pages 62-83

  Christ, Torsten ^b   Galindo Tovar, Alejandro ^b   Thoms, Marcus ^b   Ravens, Ursula ^b   Kaumann, Alberto J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

1 and 2 adrenoceptors; ( ) adrenaline; ( ) noradrenaline; Calcium current; Phosphodiesterases; Rat atrium; Sinoatrial node; Ventricle

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ADRENALIN; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CALCIUM CHANNEL L TYPE; CILOSTAMIDE; ISOBUTYLMETHYLXANTHINE; NORADRENALIN; PHOSPHODIESTERASE III; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PRAZOSIN; ROLIPRAM; QUINOLONE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CALCIUM CURRENT; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; HEART LEFT ATRIUM; HEART PAPILLARY MUSCLE; HEART RATE; HEART VENTRICLE CONTRACTILITY; INOTROPISM; L TYPE CALCIUM CURRENT; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SINUS NODE; STATISTICAL ANALYSIS; TACHYCARDIA; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; HEART ATRIUM FUNCTION; HEART CONTRACTION; HEART MUSCLE CELL; HEART VENTRICLE FUNCTION; IN VITRO STUDY; MALE; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ATRIAL FUNCTION; CALCIUM CHANNELS, L-TYPE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DOSE-RESPONSE RELATIONSHIP, DRUG; EPINEPHRINE; HEART RATE; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NOREPINEPHRINE; PATCH-CLAMP TECHNIQUES; QUINOLONES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; ROLIPRAM; VENTRICULAR FUNCTION;

EID: 60849115027     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2008.00015.x     Document Type: Article

References (55)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edition (2008 revision). Br J Pharmacol 153 (Suppl. 2 S1 S209.
2. 1-adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in i/ated cardiomyocytes. J Mol Cell Cardiol 33 : 1515 1525.
3. 2+ current in rat ventricular myocytes. J Mol Cell Cardiol 41 : 716 723.
4. 1-adrenoceptors in human atrial myocardium. Naunyn Schmiedebergs Arch Pharmacol 374 : 249 253.
5. DiFrancesco D, Tortora P (1991). Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature 351 : 145 147.
6. Fischmeister R, Castro LRV, Abi-Gerges A, Rochais F, Jurevicius J, Leroy J et al. (2006). Compartmentation of cyclic nucleotide signalling in the heart. The role of cyclic nucleotide phosphodiesterases. Circ Res 99 : 816 828.
7. 1-adrenoceptors. Br J Pharmacol 153 : 710 720.
8. Gettys TW, Blackmore PF, Redmon JB, Beebe SJ, Corbin JD (1987). Short-term feedback regulation of cAMP by accelerated degradation in rat tissues. J Biol Chem 262 : 333 339.
9. 2-adrenoceptors of human heart. Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline. Naunyn Schmiedebergs Arch Pharmacol 331 : 60 70.
10. 2-adrenoceptor. Br J Pharmacol 131 : 594 600.
11. Heaslip RJ, Buckley SK, Sickels BD, Grimes D (1999). Bronchial vs cardiovascular activities of selective phosphodiesterase inhibitors in the anesthetized beta-blocked dog. J Pharmacol Exp Ther 257 : 741 747.
12. 3-adrenoceptor function in murine heart. Br J Pharmacol 136 : 217 229.
13. Hüser J, Lipsius SL, Blatter LA (1996). Calcium gradients during excitation-contraction coupling in cat atrial myocytes. J Physiol 494 : 641 651.
14. Juberg EN, Minneman KP, Abel PW (1985). Beta1- and beta2-adrenoceptor binding and functional response in right and left atria of rat heart. Naunyn Schmiedebergs Arch Pharmacol 331 : 60 70.
15. Katano Y, Endoh M (1992). Effects of a cardiotonic quinolinone derivative Y-20487 on the positive inotropic action and cyclic AMP-accumulation in rat ventricular myocardium: comparison with rolipram, Ro 20-1724, milrinone, and isobutylmethylxanthine. Cardiovasc Pharmacol 20 : 715 722.
16. 2-adrenoceptors activated by (-)-adrenaline in rat sinoatrial node. Naunyn Schmiedebergs Arch Pharmacol 332 : 406 409.
17. 3-adrenoceptor in the rat. Br J Pharmacol 118 : 2085 2098.
18. 1-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells. Naunyn Schmiedebergs Arch Pharmacol 375 : 123 131.
19. Kitagawa Y, Adachi-Akahane S, Nagao T (1995). Determination of β-adrenoceptor subtype on i/ated ventricular myocytes by use of highly selective β-antagonists. Br J Pharmacol 116 : 1635 1643.
20. 2-adrenergic cAMP signalling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart. Circulation 99 : 2458 2465.
21. 2+ in adult rat ventricular myocytes? Am J Physiol 274 (Heart Circ Physiol 43 H1308 H1314.
22. 2+ channel regulation in adult rat ventricular myocytes. Role of phosphodiesterases. Circ Res 102 : 1091 1100.
23. 2+ waves in i/ated citrate-loaded guinea-pig atrial myocytes characterised by ratiometric confocal microscopy. J Physiol 497 : 599 610.
24. Lugnier C, Müller B, Le Bec A, Beaudry C, Rousseau E (1993). Characterization of indolidan- and rolipram-sensitive cyclic nucleotide phosphodiesterases in canine and human cardiac microsomal fractions. J Pharmacol Exp Ther 265 : 1142 1151.
25. MacKenzie L, Bootman MD, Berridge MJ, Lipp P (2001). Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes. J Physiol 530 : 417 429.
26. MacKenzie SJ, Baillie GS, MacPhee I, MacKenzie C, Seamons R, McSorley T et al. (2002). Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in upstream conserved region 1 (UCR1). Br J Pharmacol 136 : 421 433.
27. 2-adrenoceptors but does not transregulate muscarinic cholinoceptors in rat heart. Naunyn Schmiedebergs Arch Pharmacol 353 : 213 225.
28. Mauz AB, Pelzer H (1990). Beta-adrenoceptor-binding studies of the cardioselective blockers bisoprolol, H-I 42 BS, and HX-CH 44 BS to heart membranes and intact ventricular myocytes of adult rats: two beta1-binding sites for bisoprolol. Cardiovasc Pharmacol 15 : 421 427.
29. Minneman KP, Hedberg A, Molinoff PB (1979). Comparison of beta adrenergic receptor subtypes in mammalian tissues. J Pharmacol Exp Ther 211 : 502 508.
30. Mongillo M, Mcsoley T, Evellin S, Sood A, Lissandron V, Terrin A et al. (2004). Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res 95 : 65 75.
31. 2 receptors, propranolol-resistant binding sites and on some subsequent steps in intracellular signalling. Naunyn Schmiedebergs Arch Pharmacol 368 : 366 376.
32. Mysliveček J, Novakova M, Palkkovits M, Krizanova O, Kvetnansky R (2006). Distribution of mRNA and binding sites of adrenoceptors and muscarinic receptors in the rat heart. Life Sci 79 : 112 120.
33. 1-adrenergic receptor-mediated signalling. Circ Res 99 : 1084 1091.
34. Okruhlicova L, Tribulova N, Eckly A, Lugnier C, Zlezak J (1996). Cytochemical distribution of cyclic AMP-dependent 3′5′-nucleotide phosphodiesterases in the rat myocardium. Histochem J 28 : 165 172.
35. 3- adrenoceptor function. Naunyn Schmiedebergs Arch Pharmacol 361 : 134 145.
36. Osadchii OE (2007). Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease. Cardiovasc Drugs Ther 21 : 171 194.
37. Rochais F, Vandecasteele G, Lefebvre F, Lugnier C, Lum H, Mazet J-Lm Cooper DMF et al. (2004). Negative feedback exerted by PKA and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes. An in vivo study using adenovirus-mediated expression of CNG channels. J Biol Chem 279 : 52095 52105.
38. Rochais F, Abi-Gerges A, Horner K, Lefebvre F, Cooper DMF, Conti M et al. (2006). A specific pattern of phosphodiesterase controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Circ Res 98 : 1081 1088.
39. 2-adrenoceptor subtypes in the rat sinoatrial node and stellate ganglia by quantitative autoradiography. Neurosci Lett 96 : 35 41.
40. Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY et al. (2006). Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci USA 103 : 12923 12928.
41. Smith CJ, Vasta V, Degerman E, Belfrage P, Manganiello VC (1991). Hormone sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterases in rat adipocytes. J Biol Chem 266 : 13385 13390.
42. Tanaka H, Clark RB, Giles WR (1996). Positive chronotropic responses of rabbit sino-atrial node cells to flash-photolysis of caged isoproterenol and cyclic AMP. Proc Biol Sci 263 : 241 248.
43. Taniguchi T, Fujiwara M, Ohsumi K (1977). Possible involvement of cyclic adenosine 3′:5′-monophosphate in the genesis of catecholamine- induced tachycardia in i/ated rabbit sinoatrial node. J Pharmacol Exp Ther 201 : 678 688.
44. Vargas ML, Hernandez J, Kaumann AJ (2006). Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle. Br J Pharmacol 147 : 158 163.
45. 2+ current in rat ventricular myocytes. Br J Pharmacol 127 : 65 74.
46. 2+ release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells. Circ Res 90 : 73 79.
47. Vinogradova TM, Lyashkov AE, Zhu W, Spurgeon H, Maltsev VA, Lakatta EG (2005). Constitutive phosphodiesterase activity confers negative feedback on intrinsic cAMP-PKA regulation of local rhythmic subsarcolemmal calcium release and spontaneous beating in rabbit sinoatrial node. Biophys J 88 : 303a.
48. 2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res 98 : 505 514.
49. 2+ release to control normal sinoatrial node cell automaticity. In : Cardiac electrophysiology: with a special celebration of the centenary of the discovery of the sinoatrial and atrioventricular nodes. Focused Meeting of The Physiological Society, University of Manchester, 5-6 September 2007. Proceedings p36-p37.
50. 2+ releases. Circ Res 102 : 761 769.
51. Weishaar RE, Kobylarz-Singer DC, Steffen RP, Kaplan HR (1987). Subclasses of cyclic AMP-specific phosphodiesterases in left ventricular muscle and their involvement in regulating myocardial contractility. Circ Res 61 : 539 547.
52. Witte K, Hu K, Swiatek J, Müssig C, Ertl G, Lemmer B (2000). Experimental heart failure in rats: effects of cardiovascular circadian rhythms and on myocardial β-adrenergic signalling. Cardiovasc Res 47 : 350 358.
53. 2-adrenoceptors to a Pertussis toxin-sensitive G-protein in cardiac myocytes. Mol Pharmacol 47 : 322 329.
54. Yamasaki Y, Furuya Y, Araki K, Matssura K, Kobayashi M, Ogata T (1997). Ultra-high re/ution scanning electron microscopy of the sarcoplasmic reticulum of the rat atrial myocardial cells. Anat Rec 248 : 70 75.
55. Yatani A, Colina J, Imoto Y, Reeves JP, Birnbaumer L, Brown AM (1987). Direct regulation by G protein acting on the cardiac pacemaker channel. Science 249 : 1163 1166.