Frequency of specific CD8+ T cells for a promiscuous epitope derived from Trypanosoma cruzi KMP-11 protein in chagasic patients

Parasite Immunology

Volumn 32, Issue 7, 2010, Pages 494-502

  Lasso, P ^a   Mesa, D ^a   Cuellar A ^a   Guzman F ^b   Bolanos N ^c   Rosas, F ^d   Velasco, V ^d   Del Carmen Thomas, M ^e   Lopez, M C ^e   Gonzalez, J M ^c   Puerta, C J ^a  

^a PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

^c UNIVERSIDAD DE LOS ANDES   (Colombia)

^d Cardiovascular Center   (Colombia)

^e INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

CD8+T cell; Chagas' disease; HLA A2 supertype; Trypanosoma cruzi

Indexed keywords

EPITOPE; HLA A ANTIGEN; HLA A2 ANTIGEN; INTERLEUKIN 2; MEMBRANE PROTEIN; PERFORIN; PROTEIN KMP 11; TETRAMER; UNCLASSIFIED DRUG; GAMMA INTERFERON; PROTOZOAL PROTEIN;

ADULT; AGED; ARTICLE; CD8+ T LYMPHOCYTE; CHAGAS DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; MALE; MOLECULAR RECOGNITION; MOLECULAR TYPING; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; ALLELE; BIOSYNTHESIS; GENETICS; GENOTYPE; IMMUNOLOGY; MIDDLE AGED;

ADULT; AGED; ALLELES; CD8-POSITIVE T-LYMPHOCYTES; CHAGAS DISEASE; EPITOPES, T-LYMPHOCYTE; FEMALE; GENOTYPE; HLA-A2 ANTIGEN; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2; MALE; MIDDLE AGED; PERFORIN; PROTOZOAN PROTEINS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 77953532671     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2010.01206.x     Document Type: Article

References (48)

1. World Health Organization. Control of Chagas' disease. WHO Technical Report Series 2002 905: 1 109.
2. Schmunis GA. Epidemiology of Chagas disease in non-endemic countries: the role of international migration. Mem Inst Oswaldo Cruz 2007 102: 75 85.
3. Tarleton RL Zhang L. Chagas disease etiology: autoimmunity or parasite persistence? Parasitol Today 1999 15: 94 99.
4. Tarleton RL. Parasite persistence in the aetiology of Chagas disease. Int J Parasitol 2001 31: 550 554.
5. Tanowitz HB, Kirchhoff LV, Simon D, Morris SA, Weiss LM Wittner M. Chagas disease. Clin Microbiol Rev 1992 5: 400 419.
6. Teixeira A, Nascimiento R Sturm N. Evolution and pathology in Chagas disease-a review. Mem Inst Oswaldo Cruz 2006 101: 463 491.
7. Tarleton RL, Koller BH, Latour A Postan M. Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature 1992 356: 338 340.
8. + T cells in Trypanosoma cruzi infection. Immunol Rev 2004 201: 304 317.
9. Tarleton RL, Sun J, Zhang L Postan M. Depletion of T-cell subpopulations results in exacerbation of myocarditis and parasitism in experimental Chagas' disease. Infect Immun 1994 62: 1820 1829.
10. + T cells reside in nonlymphoid tissues during chronic Trypanosoma cruzi infection. J Immunol 2003 170: 2264 2268.
11. Laucella SA, Postan M, Martin D, et al. Frequency of interferon-gamma- producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease. J Infect Dis 2004 189: 909 918.
12. Martin DL Tarleton RL. Antigen-specific T cells maintain an effector memory phenotype during persistent Trypanosoma cruzi infection. J Immunol 2005 174: 1594 1601.
13. + T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes. PLoS Pathog 2006 2: e77.
14. + T cells in chronic Chagas disease. PLoS Negl Trop Dis 2008 2: e288.
15. + T cells leading to immunodominance. J Immunol 2008 180: 1737 1748.
16. + T lymphocytes in response to the K1 peptide from KMP-11 protein in patients infected with Trypanosoma cruzi. Parasite Immunol 2006 28: 101 105.
17. Garcia F, Sepulveda P, Liegeard P, et al. Identification of HLA-A*0201-restricted cytotoxic T-cell epitopes of Trypanosoma cruzi TcP2β protein in HLA-transgenic mice and patients. Microbes Infect 2003 5: 351 359.
18. + epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients. Microbes Infect 2005 7: 688 697.
19. Stebeck CE, Beecroft RP, Singh BN, et al. Kinetoplastid membrane protein-11 (KMP-11) is differentially expressed during the life cycle of African trypanosomes and is found in a wide variety of kinetoplastid parasites. Mol Biochem Parasitol 1995 71: 1 13.
20. Thomas MC, García-Pérez JL, Alonso C López MC. Molecular characterization of KMP11 from Trypanosoma cruzi: a cytoskeleton-associated protein regulated at the translational level. DNA Cell Biol 2000 19: 47 57.
21. Marañon C, Thomas MC, Planelles L López MC. The immunization of A2/K(b) transgenic mice with the KMP11-HSP70 fusion protein induces CTL response against human cells expressing the T. cruzi KMP11 antigen: identification of A2-restricted epitopes. Mol Immunol 2001 38: 279 287.
22. Planelles L, Thomas MC, Alonso C López MC. DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection. Infect Immun 2001 69: 6558 6563.
23. Thomas MC, Longobardo MV, Carmelo E, et al. Mapping of the antigenic determinants of the T. cruzi kinetoplastid membrane protein-11. Identification of a linear epitope specifically recognized by human Chagasic sera. Clin Exp Immunol 2001 123: 465 471.
24. Díez H, Guzmán F, Alba MP, et al. Immunological and structural characterization of an epitope from the Trypanosoma cruzi KMP-11 protein. Peptides 2007 28: 1520 1526.
25. Kuschnir E, Sgammini H, Castro R, Evequoz C, Ledesma R Brunetto J. Evaluation of cardiac function by radioisotopic angiography, in patients with chronic Chagas cardiopathy. Arq Bras Cardiol 1985 45: 249 256.
26. Parham P Brodsky F. Partial purification and some properties of BB7.2: a cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28. Hum Immunol 1981 3: 277 299.
27. Bunce M, O'Neill CM, Barnardo MC, et al. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 1995 46: 355 367.
28. Darrah PA, Patel DT, De Luca PM, et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 2007 13: 843 850.
29. + T cells correlate with function, differentiation stage, and antigen exposure. J Virol 2009 83: 2862 2871.
30. Morens DM, Folkers GK Fauci AS. The challenge of emerging and re-emerging infectious diseases. Nature 2004 430: 242 249.
31. Tarleton RL. Immune system recognition of Trypanosoma cruzi. Curr Opin Immunol 2007 19: 430 434.
32. Tarleton RL, Grusby MJ, Postan M Glimcher LH. Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I-and class II-restricted T cells in immune resistance and disease. Int Immunol 1996 8: 13 22.
33. + T cell function to immune control of Trypanosoma cruzi. Parasite Immunol 1998 20: 207 216.
34. + T cells during chronic viral infection. Nature 2006 439: 682 687.
35. + T cell dysfunction during chronic viral infection. Curr Opin Immunol 2007 19: 408 415.
36. Wizel B, Palmieri M, Mendoza C, et al. Human infection with Trypanosoma cruzi induces parasite antigen-specific cytotoxic T lymphocyte responses. J Clin Invest 1998 102: 1062 1071.
37. Sette A Fikes J. Epitope-based vaccines: an update on epítope identification, vaccine design and delivery. Curr Opin Immunol 2003 15: 461 470.
38. Rodríguez P, Escalante M, Díez H, et al. Estudio de la variabilidad de seis cepas colombianas de Trypanosoma cruzi mediante polimorfismos de longitud de fragmentos de restricción (RFLP) y amplificación aleatoria de ADN polimórfico (RAPD). Biomédica 2002 22: 263 271.
39. Atwood JA 3rd., Weatherly DB, Minning TA, et al. The Trypanosoma cruzi proteome. Science 2005 309: 473 476.
40. Cerqueira G, Bartholomeu D, DaRocha W, et al. Sequence diversity and evolution of multigene families in Trypanosoma cruzi. Mol Biochem Parasitol 2007 157: 65 72.
41. Yewdell JW Bennink JR. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu Rev Immunol 1999 17: 51 88.
42. Sidney J, Peters B, Frahm N, Brander C Sette A. HLA class I supertypes: a revised and updated classification. BMC Immunol 2008 9: 1 15.
43. Sette A Sidney J. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and-B polymorphism. Immunogenetics 1999 50: 201 212.
44. Sidney J, Southwood J, Mann D, Fernandez M, Newman M Sette A. Majority of peptides binding HLA-A*0201 with high affinity crossreact with other A2-supertype molecules. Hum Immunol 2001 62: 1200 1216.
45. Sallusto F, Geginat J Lanzavecchia A. Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 2004 22: 745 763.
46. + T central memory response in chronic Chagas disease. Nat Med 2008 14: 542 550.
47. + T cell memory during persistent Trypanosoma cruzi infection. J Immunol 2008 181: 2644 2650.
48. Fiuza JA, Fujiwara RT, Gomes JA, et al. Profile of central and effector memory T cells in the progression of chronic human chagas disease. PLoS Negl Trop Dis 2009 3: e512.