Suppression of tumor necrosis factor-activated nuclear transcription Factor-κB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by β-lapachone

Biochemical Pharmacology

Volumn 57, Issue 7, 1999, Pages 763-774

  Manna, Sunil K ^a   Gad, Yash P ^a   Mukhopadhyay, Asok ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Apoptosis; JNK; Lapachone; NF B; TNF

Indexed keywords

ACETYLCYSTEINE; BETA LAPACHONE; CASPASE 3; CERAMIDE; DITHIOTHREITOL; DNA; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PLANT EXTRACT; PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG DNA BINDING; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPORTER GENE; T LYMPHOCYTE;

ACETYLCYSTEINE; APOPTOSIS; BASE SEQUENCE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASPASE 3; CASPASES; CELL LINE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION; GENES, REPORTER; HELA CELLS; HUMANS; I-KAPPA B PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NAPHTHOQUINONES; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

EID: 0032965633     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(98)00354-2     Document Type: Article

References (42)

1. Hooker S.C. Lomatiol. Part II. Its occurrence, constitution, relation to and conversion into lapachol. Also a synthesis of lapachol. J Am Chem Soc. 58:1936;1181-1190.
2. Schuerch A.R., Wehrli W. β-Lapachone, an inhibitor of oncornavirus reverse transcriptase and eukaryotic DNA polymerase-α. Inhibitory effect, thiol dependency and specificity. Eur J Biochem. 84:1978;197-205.
3. Gonçalves A.M., Vasconcellos M.E., Docampo R., Cruz F.S., de Souza W., Leon W. Evaluation of the toxicity of 3-allyl-β-lapachone against Trypanosoma cruzi bloodstream forms. Mol Biochem Parasitol. 1:1980;167-176.
4. Guiraud P., Steiman R., Campos-Takaki G.M., Seigle-Murandi F., Simeon de Buochberg M. Comparison of antibacterial and antifungal activities of lapachol and β-lapachone. Planta Med. 60:1994;373-374.
5. Boothman D.A., Trask D.K., Pardee A.B. Inhibition of potentially lethal DNA damage repair in human tumor cells by β-lapachone, an activator of topoisomerase I. Cancer Res. 49:1989;605-612.
6. Li C.J., Averboukh L., Pardee A.B. β-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 268:1991;22463-22468.
7. Li C.J., Zhang L.J., Dezube B.J., Crumpacker C.S., Pardee A.B. Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication. Proc Natl Acad Sci USA. 90:1993;1839-1842.
8. Li C.J., Wang C., Pardee A.B. Induction of apoptosis by β-lapachone in human prostate cancer cells. Cancer Res. 55:1995;3712-3715.
9. Planchon S.M., Wuerzberger S., Frydman B., Witiak D.T., Hutson P., Church D.R., Wilding G., Boothman D.A. β-Lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells A p53-independent response . Cancer Res. 55:1995;3706-3711.
10. Mehta K., Pantazis P., McQueen T., Aggarwal B.B. Curcumin (diferuloylmethane) is a potent antiproliferative agent against human breast tumor cell lines. Anticancer Drugs. 8:1997;470-481.
11. Singh S., Aggarwal B.B. Activation of transcription factor NF-κB is suppressed by curcumin (diferulolylmethane). J Biol Chem. 270:1995;24995-25000.
12. Huang T.S., Lee S.C., Lin J.K. Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. Proc Natl Acad Sci USA. 88:1991;5292-5296.
13. Baeuerle P.A., Baichwal V.R. NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv Immunol. 65:1997;111-137.
14. Baichwal V.R., Baeuerle P.A. Apoptosis Activate NF-κB or die? Curr Biol. 7:1997;R94-R96.
15. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 270:1995;16483-16486.
16. Verheij M., Bose R., Lin X.H., Yao B., Jarvis W.D., Grant S., Birrer M.J., Szabo E., Zon L.I., Kyriakis J.M., Haimovitz-Friedman A., Fuks Z., Kolesnick R.N. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. 380:1996;75-79.
17. Zhou G., Kuo M.T. NF-κB-mediated induction of mdr1b expression by insulin in rat hepatoma cells. J Biol Chem. 272:1997;15174-15183.
18. Chaturvedi M.M., Kumar A., Darnay B.G., Chainy G.B.N., Agarwal S., Aggarwal B.B. Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-κB activation, IκBα phosphorylation, and degradation. J Biol Chem. 272:1997;30129-30134.
19. Cowley S., Paterson H., Kemp P., Marshall C.J. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell. 77:1994;841-852.
20. Haridas V., Darnay B.G., Natarajan K., Heller R., Aggarwal B.B. Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, NF-κB activation, and c-Jun kinase activation. J Immunol. 160:1998;3152-3162.
21. Kumar A., Manna S.K., Dhawan S., Aggarwal B.B. HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1. J Immunol. 161:1998;776-781.
22. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning A Laboratory Manual . 2nd Edn. 1989;Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
23. Chaturvedi M.M., LaPushin R., Aggarwal B.B. TNF andlymphotoxin Qualitative and quantitative differences in the mediation of early and late cellular responses . J Biol Chem. 269:1994;14575-14583.
24. Mahon T.M., O'Neill L.A.J. Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-κB activation in T lymphocytes. Evidence for covalent modification of the p50 subunit. J Biol Chem. 270:1995;28557-28564.
25. Finco T.S., Beg A.A., Baldwin A.S. Jr. Inducible phosphorylation of IκBα is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors. Proc Natl Acad Sci USA. 91:1994;11884-11888.
26. Bonizzi G., Piette J., Merville M.P., Bours V. Distinct signal transduction pathways mediate nuclear factor-κB induction by IL-1β in epithelial and lymphoid cells. J Immunol. 159:1997;5264-5272.
27. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells AP-1 as secondary antioxidant-responsive factor . EMBO J. 12:1993;2005-2015.
28. Lee F.S., Hagler J., Chen Z.J., Maniatis T. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell. 88:1997;213-222.
29. Hirano M., Osada S., Aoki T., Hirai S., Hosaka M., Inoue J., Ohno S. MEK kinase is involved in TNF α-induced NF-κB activation and degradation of IκB-α J Biol Chem. 271:1996;13234-13238.
30. Schaffner-Sabba K., Schmidt-Ruppin K.H., Wehrli W., Schuerch A.R., Wasley J.W. β-Lapachone: Synthesis of derivatives and activities in tumor models. J Med Chem. 27:1984;990-994.
31. 2 in NF-κB activation by either cytokine in both primary and transformed endothelial cells. J Biol Chem. 272:1997;25941-25950.
32. Stancovski I., Baltimore D. NF-κB activation The IκB kinase revealed? Cell. 91:1997;299-302.
33. Chu Z.L., McKinsey T.A., Liu L., Gentry J.J., Malim M.H., Ballard D.W. Suppression of TNF-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control. Proc Natl Acad Sci USA. 94:1997;10057-10062.
34. Sarma V., Lin Z., Clark L., Rust B.M., Tewari M., Noelle R.J., Dixit V.M. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J Biol Chem. 270:1995;12343-12346.
35. Jones P.L., Ping D., Boss J.M. TNF alpha and IL-1β regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-β and NF-κB. Mol Cell Biol. 17:1997;6970-6981.
36. Muller J.M., Rupec R.A., Baeuerle P.A. Study of gene regulation by NF-κ B and AP-1 in response to reactive oxygen intermediates. Methods. 11:1997;301-312.
37. Buttke T.M., Sandstrom P.A. Oxidative stress as a mediator of apoptosis. Immunol Today. 15:1994;7-10.
38. Molina Portela M.P., Stoppani A.O.M. Redox cycling of β-lapachone and related o-naphthoquinones in the presence of dihydrolipoamide and oxygen. Biochem Pharmacol. 51:1996;275-283.
39. Hayashi T., Ueno Y., Okamoto T. Oxidoreductive regulation of nuclear factor κ B. Involvement of a cellular reducing catalyst thioredoxin. J Biol Chem. 268:1993;11380-11388.
40. Fischer E.H., Charbonneau H., Tonks N.K. Protein tyrosine phosphatases A diverse family of intracellular and transmembrane enzymes . Science. 253:1991;401-406.
41. Singh S., Aggarwal B.B. Protein tyrosine phosphatase inhibitors block TNF-dependent activation of the nuclear transcription factor NF-κB. J Biol Chem. 270:1995;10631-10639.
42. Menon S.D., Guy G.R., Tan Y.H. Involvement of a putative protein-tyrosine phosphatase and IκB-α serine phosphorylation in nuclear factor κB activation by TNF. J Biol Chem. 270:1995;18881-18887.