Significant dose can be lost by extended delivery times in IMRT with x rays but not high-LET radiations

Medical Physics

Volumn 37, Issue 6, 2010, Pages 2457-2465

  Joiner, Michael C ^a   Mogili, Nagaraju ^a   Marples, Brian ^a,b   Burmeister, Jay ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

Dose protraction; IMRT; Incomplete repair; Loss of effectiveness; Neutrons; Simulation

Indexed keywords

CELL CULTURE; CELLS; NEUTRONS; RADIOTHERAPY; TUMORS; X RAYS;

BIOLOGICAL EFFECTS; CLINICAL RADIOTHERAPY; DOSE PROTRACTION; EXTENDED DELIVERIES; IMRT; SIMULATION; TREATMENT OUTCOMES; X RAY IRRADIATION;

NEUTRON IRRADIATION;

EID: 77953501435     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3425792     Document Type: Article

References (42)

1. C. Nutting, D. P. Dearnaley, and S. Webb, " Intensity modulated radiation therapy: A clinical review.," Br. J. Radiol. BJRAAP 0007-1285 73, 459-469 (2000).
2. S. X. Chang, T. J. Cullip, and K. M. Deschesne, " Intensity modulation delivery techniques: Step & shoot' MLC auto-sequence versus the use of a modulator.," Med. Phys. MPHYA6 0094-2405 27, 948-959 (2000). 10.1118/1.598989 (Pubitemid 30350003)
3. C. S. Chui, M. F. Chan, E. Yorke, S. Spirou, and C. C. Ling, " Delivery of intensity-modulated radiation therapy with a conventional multileaf collimator: Comparison of dynamic and segmental methods.," Med. Phys. MPHYA6 0094-2405 28, 2441-2449 (2001). 10.1118/1.1418018 (Pubitemid 34031530)
4. P. Alaei, P. D. Higgins, R. Weaver, and N. Nguyen, " Comparison of dynamic and step-and-shoot intensity-modulated radiation therapy planning and delivery.," Med. Dosim. ZZZZZZ 0739-0211 29, 1-6 (2004). 10.1016/j.meddos.2003.10.002 (Pubitemid 38352825)
5. J. S. Welsh, J. P. Limmer, S. P. Howard, D. Diamond, P. M. Harari, and W. Tome, " Precautions in the use of intensity-modulated radiation therapy.," Technol. Cancer Res. Treat. TCRTBS 1533-0346 4, 203-210 (2005).
6. T. Bortfeld, " IMRT: A review and preview.," Phys. Med. Biol. PHMBA7 0031-9155 51, R363-379 (2006). 10.1088/0031-9155/51/13/R21 (Pubitemid 43958624)
7. D. J. Brenner and E. J. Hall, " Conditions for the equivalence of continuous to pulsed low dose rate brachytherapy.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 20, 181-190 (1991). 10.1016/0360-3016(91)90158-Z
8. J. Z. Wang, M. Guerrero, and X. A. Li, " How low is the alpha/beta ratio for prostate cancer?," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 55, 194-203 (2003). 10.1016/S0360-3016(02)03828-2 (Pubitemid 36020360)
9. G. G. Steel, J. M. Deacon, G. M. Duchesne, A. Horwich, L. R. Kelland, and J. H. Peacock, " The dose-rate effect in human tumour cells.," Radiother. Oncol. RAONDT 0167-8140 9, 299-310 (1987). 10.1016/S0167-8140(87) 80151-2
10. J. Z. Wang, X. A. Li, W. D. D'Souza, and R. D. Stewart, " Impact of prolonged fraction delivery times on tumor control: A note of caution for intensity-modulated radiation therapy (IMRT).," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 57, 543-552 (2003). 10.1016/S0360-3016(03)00499-1 (Pubitemid 37040952)
11. S. A. Roberts, J. H. Hendry, R. Swindell, J. M. Wilkinson, and R. D. Hunter, " Compensation for changes in dose-rate in radical low-dose-rate brachytherapy: A radiobiological analysis of a randomised clinical trial.," Radiother. Oncol. RAONDT 0167-8140 70, 63-74 (2004). 10.1016/j.radonc.2003.11. 010 (Pubitemid 38177164)
12. X. K. Zheng, L. H. Chen, X. Yan, and H. M. Wang, " Impact of prolonged fraction dose-delivery time modeling intensity-modulated radiation therapy on hepatocellular carcinoma cell killing.," World J. Gastroenterol. WJGAF2 1007-9327 11, 1452-1456 (2005).
13. H. D. Thames, " An incomplete-repair' model for survival after fractionated and continuous irradiations.," Int. J. Radiat. Biol. IJRBE7 0955-3022 47, 319-339 (1985). 10.1080/09553008514550461
14. R. G. Dale, " The application of the linear-quadratic model to fractionated radiotherapy when there is incomplete normal tissue recovery between fractions, and possible implications for treatments involving multiple fractions per day.," Br. J. Radiol. BJRAAP 0007-1285 59, 919-927 (1986). 10.1259/0007-1285-59-705-919
15. P. Nilsson, H. D. Thames, and M. C. Joiner, " A generalized formulation of the incomplete-repair' model for cell survival and tissue response to fractionated low dose-rate irradiation.," Int. J. Radiat. Biol. IJRBE7 0955-3022 57, 127-142 (1990). 10.1080/09553009014550401
16. W. T. Millar and P. A. Canney, " Derivation and application of equations describing the effects of fractionated protracted irradiation, based on multiple and incomplete repair processes. Part 1. Derivation of equations.," Int. J. Radiat. Biol. IJRBE7 0955-3022 64, 275-291 (1993). 10.1080/09553009314551431
17. P. A. Canney and W. T. Millar, " Biphasic cellular repair and implications for multiple field radiotherapy treatments.," Br. J. Radiol. BJRAAP 0007-1285 70, 817-822 (1997).
18. S. M. Bentzen, M. I. Saunders, and S. Dische, " Repair halftimes estimated from observations of treatment-related morbidity after CHART or conventional radiotherapy in head and neck cancer.," Radiother. Oncol. RAONDT 0167-8140 53, 219-226 (1999). 10.1016/S0167-8140(99)00151-6
19. S. M. Bentzen and M. C. Joiner, in Basic Clinical Radiobiology, edited by, M. C. Joiner, and, A. J. Van Der Kogel, (Hodder Arnold, London, 2009), pp. 120-134.
20. R. L. Maughan and M. Yudelev, " Physical characteristics of a clinical d (48.5) +Be neutron therapy beam produced by a superconducting cyclotron.," Med. Phys. MPHYA6 0094-2405 22, 1459-1465 (1995). 10.1118/1.597570
21. P. R. Barber, B. Vojnovic, J. Kelly, C. R. Mayes, P. Boulton, M. Woodcock, and M. C. Joiner, " Automated counting of mammalian cell colonies.," Phys. Med. Biol. PHMBA7 0031-9155 46, 63-76 (2001). 10.1088/0031-9155/46/1/305 (Pubitemid 32104871)
22. B. Marples, B. G. Wouters, and M. C. Joiner, " An association between the radiation-induced arrest of G2 phase cells and low-dose hyper-radiosensitivity: A plausible underlying mechanism?," Radiat. Res. RAREAE 0033-7587 160, 38-45 (2003). 10.1667/RR3013
23. M. C. Joiner, " A comparison of the effects of p(62)-Be and d(16)-Be neutrons in the mouse kidney.," Radiother. Oncol. RAONDT 0167-8140 13, 211-224 (1988). 10.1016/0167-8140(88)90058-8
24. M. C. Joiner and A. J. Van Der Kogel, Basic Clinical Radiobiology (Hodder Arnold, London, 2009), p. 375.
25. M. C. Joiner, A. Rojas, and H. Johns, " A test of equal effect per fraction in the kidney of the mouse.," Radiat. Res. RAREAE 0033-7587 130, 227-235 (1992). 10.2307/3578280
26. M. C. Joiner, A. Rojas, and H. Johns, " Does the repair capacity of skin change with repeated exposure to x-rays?," Int. J. Radiat. Biol. IJRBE7 0955-3022 55, 993-1005 (1989). 10.1080/09553008914551021
27. C. C. Ling, I. J. Spiro, and R. Stickler, " Dose-rate effect between 1 and 10 Gy/min in mammalian cell culture.," Br. J. Radiol. BJRAAP 0007-1285 57, 723-728 (1984). 10.1259/0007-1285-57-680-723
28. S. H. Benedict, P. S. Lin, R. D. Zwicker, D. T. Huang, and R. K. Schmidt-Ullrich, " The biological effectiveness of intermittent irradiation as a function of overall treatment time: Development of correction factors for linac-based stereotactic radiotherapy.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 37, 765-769 (1997). 10.1016/S0360-3016(97)00023-0 (Pubitemid 27181306)
29. X. Mu, P. O. Lofroth, M. Karlsson, and B. Zackrisson, " The effect of fraction time in intensity modulated radiotherapy: Theoretical and experimental evaluation of an optimisation problem.," Radiother. Oncol. RAONDT 0167-8140 68, 181-187 (2003). 10.1016/S0167-8140(03)00165-8 (Pubitemid 38367552)
30. W. A. Toḿ, J. Welsh, and J. F. Fowler, " The effect of fraction time in intensity modulated radiotherapy: Theoretical and experimental evaluation of an optimization problem (the real conclusions): In regard to Mu Radiother Oncol 2003; 68: 181-187 [Letter].," Radiother. Oncol. RAONDT 0167-8140 72, 113-114 (2004). 10.1016/j.radonc.2004.04.002 (Pubitemid 38952868)
31. J. F. Fowler, J. S. Welsh, and S. P. Howard, " Loss of biological effect in prolonged fraction delivery.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 59, 242-249 (2004). 10.1016/j.ijrobp.2004.01.004
32. Y. Shibamoto, M. Ito, C. Sugie, H. Ogino, and M. Hara, " Recovery from sublethal damage during intermittent exposures in cultured tumor cells: Implications for dose modification in radiosurgery and IMRT.," Int. J. Radiat. Oncol. Biol. Phys. 59, 1484-1490 (2004). 10.1016/j.ijrobp.2004.04.039 0360-3016
33. F. Sterzing, M. W. Munter, M. Schafer, P. Haering, B. Rhein, C. Thilmann, and J. Debus, " Radiobiological investigation of dose-rate effects in intensity-modulated radiation therapy.," Strahlenther. Onkol. STONE4 0179-7158 181, 42-48 (2005). 10.1007/s00066-005-1290-1 (Pubitemid 40174985)
34. S. B. Curtis, " Lethal and potentially lethal lesions induced by radiation-A unified repair model.," Radiat. Res. RAREAE 0033-7587 106, 252-270 (1986). 10.2307/3576798
35. H. Paganetti, " Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 63, 892-900 (2005). 10.1016/j.ijrobp.2005. 07.953
36. L. Santanam, T. He, M. Yudelev, J. D. Forman, C. G. Orton, F. V. Heuvel, R. L. Maughan, and J. Burmeister, " Intensity modulated neutron radiotherapy for the treatment of adenocarcinoma of the prostate.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 68, 1546-1556 (2007). 10.1016/j.ijrobp.2007.04.040
37. J. H. Hendry, S. M. Bentzen, R. G. Dale, J. F. Fowler, T. E. Wheldon, B. Jones, A. J. Munro, N. J. Slevin, and A. G. Robertson, " A modeled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy.," Clin. Oncol. ZZZZZZ 0305-7399 8, 297-307 (1996). 10.1016/S0936-6555(05)80715-0 (Pubitemid 26382026)
38. S. G. Williams, J. M. Taylor, N. Liu, Y. Tra, G. M. Duchesne, L. L. Kestin, A. Martinez, G. R. Pratt, and H. Sandler, " Use of individual fraction size data from 3756 patients to directly determine the alpha/beta ratio of prostate cancer.," Int. J. Radiat. Oncol., Biol., Phys. IOBPD3 0360-3016 68, 24-33 (2007). 10.1016/j.ijrobp.2006.12.036
39. J. R. Owen, A. Ashton, J. M. Bliss, J. Homewood, C. Harper, J. Hanson, J. Haviland, S. M. Bentzen, and J. R. Yarnold, " Effect of radiotherapy fraction size on tumour control in patients with early-stage breast cancer after local tumour excision: Long-term results of a randomised trial.," Lancet Oncol. LOANBN 1470-2045 7, 467-471 (2006). 10.1016/S1470-2045(06)70699-4 (Pubitemid 43779171)
40. T. R. Mackie, T. Holmes, S. Swerdloff, P. Reckwerdt, J. O. Deasy, J. Yang, B. Paliwal, and T. Kinsella, " Tomotherapy: A new concept for the delivery of dynamic conformal radiotherapy.," Med. Phys. MPHYA6 0094-2405 20, 1709-1719 (1993). 10.1118/1.596958 (Pubitemid 24001191)
41. C. X. Yu, " Intensity-modulated arc therapy with dynamic multileaf collimation: An alternative to tomotherapy.," Phys. Med. Biol. PHMBA7 0031-9155 40, 1435-1449 (1995). 10.1088/0031-9155/40/9/004
42. M. Shaikh, J. Burmeister, M. C. Joiner, S. Pandya, B. Zhao, and Q. Liu, " Biological effect of different IMRT delivery techniques: SMLC, DMLC and helical tomotherapy.," Med. Phys. MPHYA6 0094-2405 37, 762-770 (2010). 10.1118/1.3284369