Precautions in the use of intensity-modulated radiation therapy

Technology in Cancer Research and Treatment

Volumn 4, Issue 2, 2005, Pages 203-210

  Welsh, James S ^a   Limmer, Jeffery P ^b   Howard, Steven P ^a   Diamond, David ^c   Harari, Paul M ^a   Tomé, Wolfgang ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b Aspirus Wausau Hospital   (United States)

^c FLORIDA HOSPITAL CANCER INSTITUTE   (United States)

Author keywords

Bystander effect; IMRT; Low dose hypersensitivity; Radiation dose rate

Indexed keywords

CANCER CONTROL; CARCINOGENESIS; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; COLLIMATOR; CONFERENCE PAPER; DNA REPAIR; DNA STRAND BREAKAGE; ERYTHEMA; HISTOGRAM; INTENSITY MODULATED RADIATION THERAPY; MITOSIS; PHOTOACTIVATION; PHOTON; RADIATION EXPOSURE; RADIOSENSITIVITY; SAFETY;

EID: 17644370595     PISSN: 15330346     EISSN: None     Source Type: Journal    
DOI: 10.1177/153303460500400209     Document Type: Conference Paper

References (35)

1. Welsh, J. and Howard, S. Fractionated Low Dose-rate Whole Abdominal Irradiation for Recurrent Malignancy. Cancer J. 7, 547-548 (2001).
2. th International Conference on Dose, Time, and Fractionation in Radiation Oncology: Biological and Physical Basis of IMRT and Tomotherapy, pp 48. Sept. (2001).
3. Wang, J. Z., Li, X. A., D'Souza, W. D., and Stewart, R. D. Impact of Prolonged Fraction Delivery Times on Tumor Control: a Note of Caution for IMRT. Int. J. Rad. Oncol. Biol. Phys. 57, 543-552 (2003).
4. Fowler, J. F., Welsh, J. S., and Howard, S. P. Loss of Biological Effect in Prolonged Fraction Delivery. Int. J. Radiat. Oncol. Biol. Phys. 59, 242-249 (2004).
5. Mu, X., Lofroth, P. O., Karlsson, M., and Zackrisson, B. The Effect of Fraction Time in Intensity Modulated Radiotherapy: Theoretical and Experimental Evaluation of an Optimization Problem. Radiother. Oncol. 68, 181-187 (2003).
6. Tomé, W. A., Welsh, J. S., and Fowler, J. F. The Effect of Fraction Time in Intensity Modulated Radiotherapy: Theoretical and Experimental Evaluation of an Optimization Problem (The Real Conclusions). Radiother. Oncol. 72, 113-114 (2004).
7. Welsh, J. S., Howard, S. P., and Fowler, J. F. Dose Rate in External Beam Radiotherapy for Prostate Cancer: An Overlooked Confounding Variable? Urology. 62, 204-206 (2003).
8. Shibamoto, Y., Ito, M., Sugie, C., Ogino, H., and Hara, M. Recovery from Sublethal Damage During Intermittent Exposures in Cultured Tumor Cells: Implications for Dose Modification in Radiosurgery and IMRT. Int. J. Radiat. Oncol. Biol. Phys. 59, 1484-1490 (2004).
9. Rawlinson, J. A., Islam, M. K., and Galbraith, D. M. Dose to Radiation Therapists from Activation at High-energy Accelerators Used for Conventional and Intensity-modulated Radiation Therapy. Med. Phys. 29, 598-608 (2002).
10. Perrin, B., Walker, A., and Mackay, R. A Model to Calculate the Induced Dose Rate Around an 18 MV ELEKTA Linear Accelerator. Phys. Med. Biol. 48, N75-81 (2003).
11. Followill, D. S., Stovall, M. S., Kry, S. F., and Ibbott, G. S. Neutron Source Strength Measurements for Varian, Siemens, Elekta, and General Electric Linear Accelerators. J. Appl. Clin. Med. Phys. 4, 189-194 (2003).
12. Lee, N. C., Chuang, J., Quivey, T., et al. Skin Toxicity Due to Intensity-modulated Radiotherapy for Head-and-Neck Carcinoma. Int. J. Rad. Oncol. Biol. Phys. 53, 630-637 (2002).
13. Tomé, W. A. and Fowler, J. F. On Cold Spots in Tumor Subvolumes. Med. Phys. 29, 1590-1598 (2002).
14. Perks, J. R., Lehmann, J., Yang, C. C., et al. RSNA Sci Assembly and Ann Meeting Prog., pp. 732 (2004).
15. Mackie, T., Kissiki, M., Jeraj, R., Tomé, W., Fenwick, J., Olivera, G., and Ritter, M. Intergal Dose in External Beam Photon Radiotherapy. Med. Phys. 31, 1721 (2004).
16. Verellen, D. and Vanhavere, F. Risk Assessment of Radiation-induced Malignancies Based on Whole-body Equivalent Dose Estimates for IMRT Treatment in the Head and Neck Region. Radiother Oncol. 53, 199-203 (1999).
17. Hall, E. J. and Wuu, C.-S. Radiation-induced Second Cancers: The Impact of 3D-CRT and IMRT. Int. J. Radiat. Oncol. Biol. Phys. 56, 83-88 (2003).
18. Glatstein, E. Intensity-modulated Radiation Therapy: The Inverse, the Converse, and the Perverse. Semin Radiat Oncol. 12, 272-281 (2002).
19. Goffman, T. E. and Glatstein, E. Intensity-modulated Radiation Therapy. Radiat. Res. 158, 115-117 (2002).
20. Sawant, S. G., Randers-Pehrson, G., Geard, C. R., et al. The Bystander Effect in Radiation Oncogenesis: I. Transformation in C3H 10 T1/2 Cells In Vitro can be Initiated in the Unirradiated Neighbors of Irradiated Cells. Radiat. Res. 155, 397-401 (2001).
21. Miller, R. C., Randers-Pehrson, G., Geard, C. R., et al. The Oncogenic Transforming Potential of the Passage of Single Alpha Particles Through Mammalian Cell Nuclei. Proc Natl Acad Sci. 96, 19-22 (1999).
22. Rothkamm, K. and Lobrich, M. Evidence for a Lack of DNA Double-strand Break Repair in Human Cell Exposed to Very Low X-ray Doses. Proc. Natl. Acad. Sci. 100, 5057-5062 (2003).
23. Welsh, J. S., Patel, R. R., Ritter, M. A., Harari, P., Mackie, T. R., and Mehta, M. P. Helical Tomotherapy: An Innovative Technology and Approach to Radiation Therapy. Technology in Cancer Research and Treatment. 1, 55-63 (2002).
24. Joiner, M. C., Marples, B., Lambin, P., et al. Low-dose Hypersensitivity: Current Status and Possible Mechanisms. Int J Radiat Oncol Biol Phys. 49, 379-389 (2001).
25. Marples, B., Wouters, B.G., Collis, S. J., Chalmers, A. J., and Joiner, M. C. Low-dose Hyper-radiosensitivity: A Consequence of Ineffective Cell Cycle Arrest of Radiation-damaged G2-phase Cells. Radiat Res. 161, 247-255 (2004).
26. Nagasawa, H. and Little, J. B. Induction of Sister Chromatid Exchanges by Extremely Low Doses of Alpha-particles. Cancer Res. 52, 6394-6396 (1992).
27. Nagasawa, H. and Little, J. B. Unexpected Sensitivity to the Induction of Mutations by Very Low Doses of Alpha-particle Radiation: Evidence for a Bystander Effect. Radiat. Res. 153, 552-557 (1999).
28. Huo, L., Nagasawa, H., and Little, J. B. HPRT Mutants Induced in Bystander Cells by Very Low Fluences of Alpha Particles Result Primarily from Point Mutations. Radiat. Res. 156, 521-525 (2001).
29. Mackie, T.R., Kapatoes, J., Ruchala, K., Lu, W., Wu, C., Olivera, G., Forrest, L., Tome, W., Welsh, J., Jeraj, R., Harari, P., Reckwerdt, P., Paliwal, B., Ritter, M., Keller, H., Fowler, J., and Mehta, M. Image Guidance for Precise Conformal Radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 56, 89-105 (2003).
30. Welsh, J. S., Bradley, K., Ruchala, K. J., Mackie, T. R., Manon, R., Patel, R., Wiederholt, P., Lock, M., Hui, S., and Mehta, M. P. Megavoltage Computed Tomography Imaging: A Potential Tool to Guide and Improve the Delivery of Thoracic Radiation Therapy. Clin. Lung Cancer 5, 303-306 (2004).
31. Tomé, W. A. and Fowler, J. F. Selective Boosting of Tumor Subvolumes. Int. J. Rad. Oncol. Biol. Phys. 48, 593-599 (2000).
32. Benedict, S. H., Lin, P. S., Zwicker, R. D., Huang, D. T., and Schmidt-Ullrich, R. K. The Biological Effectiveness of Intermittent Irradiation as a Function of Overall Treatment Time: Development of Correction Factors for Linac-based Stereotactic Radiotherapy. Int. J. Rad. Oncol. Biol. Phys. 37, 765-769 (1997).
33. Morgan, W. F., Naqvi, C., Yu, C., Smith, L. E., and Bose, M. Does the Time Required to Deliver IMRT Reduce its Biological Effectiveness? Int. J. Rad. Oncol. Biol. Phys. 54, 222 (2002).
34. Sugie, C., Ito, M., Ogino, H., Miyamoto, A., Fukaya, N., and Shibamoto, Y. Changes in the Effect of Radiation Due to Intermittent Exposures in Murine Tumors: Comparison with In Vitro Results. RSNA Sci. Assembly and Ann. Meeting. Prog., pp. 299 (2004)
35. Zhang, T., Jeraj, R., Keller, H., Lu, W., Olivera, G. H., McNutt, T. R., Mackie, T. R., and Paliwal, B. Treatment Plan Optimization Incorporating Respiratory Motion. Med. Phys. 31, 1576-1586 (2004).