Dna depletion by precipitation in the purification of cell culture-derived influenza vaccines

Chemical Engineering and Technology

Volumn 33, Issue 6, 2010, Pages 941-959

  Kröber, Tina ^a   Knöchlein, Anne ^b   Eisold, Katrin ^c   Kalbfuß Zimmermann, Bernd ^a   Reichl, Udo ^a,d  

^a MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

^b UNIVERSITY OF APPLIED SCIENCES   (Germany)

^c UNIVERSITY OF APPLIED SCIENCES JENA   (Germany)

^d OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Centrifugation; Downstream processing; Influenza virus; Selective precipitation; Tangential flow ultrafiltration

Indexed keywords

CONCENTRATION OF; DOWNSTREAM-PROCESSING; FULL FACTORIAL DESIGN; HOST CELLS; IN-CELL; INFLUENZA VACCINES; INFLUENZA VIRUS; MADIN-DARBY CANINE KIDNEY CELLS; NEURAMINIDASE; OPTIMIZED CONDITIONS; PILOT STUDIES; POLYETHYLENEIMINE; PRODUCT YIELDS; SCALE-UP; SELECTIVE PRECIPITATION; SIGMA THEORY; TANGENTIAL FLOW ULTRAFILTRATION; UNIT OPERATION;

ANIMAL CELL CULTURE; CENTRIFUGATION; CENTRIFUGES; CLARIFICATION; COMPUTATIONAL FLUID DYNAMICS; DNA; GENES; IONIC STRENGTH; OPTIMIZATION; PURIFICATION; TURBIDITY; ULTRAFILTRATION; VIRUSES;

CELL CULTURE;

HUMAN INFLUENZA VIRUS; ORTHOMYXOVIRIDAE;

EID: 77953501407     PISSN: 09307516     EISSN: 15214125     Source Type: Journal    
DOI: 10.1002/ceat.200900534     Document Type: Article

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