Monocyte transplantation for neural and cardiovascular ischemia repair

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 3, 2010, Pages 553-563

  Sanberg, Paul R ^a,b   Park, Dong Hyuk ^a   Kuzmin Nichols, Nicole ^c   Cruz, Eduardo ^d   Hossne Jr, Nelson Americo ^e   Buffolo, Enio ^e   Willing, Alison E ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c Saneron CCEL Therapeutics Inc   (United States)

^d Cryopraxis and Silvestre Laboratory   (Brazil)

^e FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Angiogenesis arteriogenesis; Bone marrow; Inflammation; Ischemia; Monocyte macrophage; Peripheral blood; Stem cells; Transplantation; Umbilical cord blood

Indexed keywords

AUTACOID;

ANGIOGENESIS; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CARDIOVASCULAR SYSTEM; CYTOLOGY; FETUS BLOOD; HUMAN; ISCHEMIA; METABOLISM; MONOCYTE; NERVOUS SYSTEM; PATHOPHYSIOLOGY; TRANSPLANTATION; VASCULARIZATION;

ANIMALS; CARDIOVASCULAR SYSTEM; FETAL BLOOD; HUMANS; INFLAMMATION MEDIATORS; ISCHEMIA; MODELS, BIOLOGICAL; MONOCYTES; NEOVASCULARIZATION, PHYSIOLOGIC; NERVOUS SYSTEM;

EID: 77953496607     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00903.x     Document Type: Article

References (109)

1. Bosco MC, Puppo M, Blengio F. Monocytes and dendritic cells in a hypoxic environment: spotlights on chemotaxis and migration. Immunobiology. 2008, 213:733-49.
2. Imhof BA, Aurrand-Lions M. Adhesion mechanisms regulating the migration of monocytes. Nat Rev Immunol. 2004, 4:432-44.
3. Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood. 2004, 104:2224-34.
4. Sunderkotter C, Steinbrink K, Goebeler M. Macrophages and angiogenesis. J Leukoc Biol. 1994, 55:410-22.
5. Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003, 3:23-35.
6. Nathan CF. Secretory products of macrophages. J Clin Invest. 1987, 79:319-26.
7. Paulnock DM, Demick KP, Coller SP. Analysis of interferon-gamma-dependent and -independent pathways of macrophage activation. J Leukoc Biol. 2000, 67:677-82.
8. Hoefer IE, Grundmann S, van Royen N. Leukocyte subpopulations and arteriogenesis: specific role of monocytes, lymphocytes and granulocytes. Atherosclerosis. 2005, 181:285-93.
9. Schruefer R, Lutze N, Schymeinsky J. Human neutrophils promote angiogenesis by a paracrine feedforward mechanism involving endothelial interleukin-8. Am J Physiol Heart Circ Physiol 2005, 288:H1186-92.
10. Kusumanto YH, Dam WA, Hospers GA. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis. 2003, 6:283-7.
11. Baggiolini M, Loetscher P. Chemokines in inflammation and immunity. Immunol Today. 2000, 21:418-20.
12. Mantovani A, Sozzani S, Locati M. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002, 23:549-55.
13. Mantovani A, Sica A, Sozzani S. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004, 25:677-86.
14. Sica A, Schioppa T, Mantovani A. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer. 2006, 42:717-27.
15. Deonarine K, Panelli MC, Stashower ME. Gene expression profiling of cutaneous wound healing. J Transl Med 2007, 5:11.
16. Shireman PK. The chemokine system in arteriogenesis and hind limb ischemia. J Vasc Surg 2007, 45:A48-56.
17. Herold J, Pipp F, Fernandez B. Transplantation of monocytes: a novel strategy for in vivo augmentation of collateral vessel growth. Hum Gene Ther. 2004, 15:1-12.
18. Capoccia BJ, Gregory AD, Link DC. Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion. J Leukoc Biol. 2008, 84:760-8.
19. Ito WD, Arras M, Scholz D. Angiogenesis but not collateral growth is associated with ischemia after femoral artery occlusion. Am J Physiol 1997, 273:H1255-65.
20. Heil M, Eitenmuller I, Schmitz-Rixen T. Arteriogenesis versus angiogenesis: similarities and differences. J Cell Mol Med. 2006, 10:45-55.
21. Scholz D, Ziegelhoeffer T, Helisch A. Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice. J Mol Cell Cardiol. 2002, 34:775-87.
22. Nagel T, Resnick N, Atkinson WJ. Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest. 1994, 94:885-91.
23. Eischen A, Vincent F, Bergerat JP. Long term cultures of human monocytes in vitro. Impact of GM-CSF on survival and differentiation. J Immunol Methods. 1991, 143:209-21.
24. Thurston G. Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis. Cell Tissue Res. 2003, 314:61-8.
25. Milkiewicz M, Ispanovic E, Doyle JL. Regulators of angiogenesis and strategies for their therapeutic manipulation. Int J Biochem Cell Biol. 2006, 38:333-57.
26. Zhang RL, Zhang ZG, Chopp M. Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy. Neuroscientist. 2005, 11:408-16.
27. Beck H, Acker T, Wiessner C. Expression of angiopoietin-1, angiopoietin-2, and tie receptors after middle cerebral artery occlusion in the rat. Am J Pathol. 2000, 157:1473-83.
28. Murdoch C, Tazzyman S, Webster S. Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J Immunol. 2007, 178:7405-11.
29. Tammela T, Enholm B, Alitalo K. The biology of vascular endothelial growth factors. Cardiovasc Res. 2005, 65:550-63.
30. Moldovan L, Moldovan NI. Role of monocytes and macrophages in angiogenesis. Exs 2005, 127-46.
31. Dirkx AE, Oude Egbrink MG, Wagstaff J. Monocyte/macrophage infiltration in tumors: modulators of angiogenesis. J Leukoc Biol. 2006, 80:1183-96.
32. Moldovan NI, Goldschmidt-Clermont PJ, Parker-Thornburg J. Contribution of monocytes/macrophages to compensatory neovascularization: the drilling of metalloelastase-positive tunnels in ischemic myocardium. Circ Res. 2000, 87:378-84.
33. Anghelina M, Moldovan L, Zabuawala T. A subpopulation of peritoneal macrophages form capillarylike lumens and branching patterns in vitro. J Cell Mol Med. 2006, 10:708-15.
34. Schmeisser A, Graffy C, Daniel WG. Phenotypic overlap between monocytes and vascular endothelial cells. Adv Exp Med Biol. 2003, 522:59-74.
35. Schmeisser A, Strasser RH. Phenotypic overlap between hematopoietic cells with suggested angioblastic potential and vascular endothelial cells. J Hematother Stem Cell Res. 2002, 11:69-79.
36. Hoenig MR, Bianchi C, Sellke FW. Hypoxia inducible factor-1 alpha, endothelial progenitor cells, monocytes, cardiovascular risk, wound healing, cobalt and hydralazine: a unifying hypothesis. Curr Drug Targets. 2008, 9:422-35.
37. Marumo T, Schini-Kerth VB, Busse R. Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells. Diabetes. 1999, 48:1131-7.
38. Lakshminarayanan V, Lewallen M, Frangogiannis NG. Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia. Am J Pathol. 2001, 159:1301-11.
39. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004, 25:581-611.
40. Mostafa LK, Jones DB, Wright DH. Mechanism of the induction of angiogenesis by human neoplastic lymphoid tissue: studies on the chorioallantoic membrane (CAM) of the chick embryo. J Pathol. 1980, 132:191-205.
41. Evans R. Effect of X-irradiation on host-cell infiltration and growth of a murine fibrosarcoma. Br J Cancer. 1977, 35:557-66.
42. Gouon-Evans V, Lin EY, Pollard JW. Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development. Breast Cancer Res. 2002, 4:155-64.
43. Schmid MC, Varner JA. Myeloid cell trafficking and tumor angiogenesis. Cancer Lett. 2007, 250:1-8.
44. Pugh-Humphreys RG. Macrophage-neoplastic cell interactions: implications for neoplastic cell growth. FEMS Microbiol Immunol. 1992, 5:289-308.
45. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002, 420:860-7.
46. Sironi M, Martinez FO, D'Ambrosio D. Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2). J Leukoc Biol. 2006, 80:342-9.
47. Nozawa H, Chiu C, Hanahan D. Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci USA. 2006, 103:12493-8.
48. Oosterling SJ, van der Bij GJ, Meijer GA. Macrophages direct tumour histology and clinical outcome in a colon cancer model. J Pathol. 2005, 207:147-55.
49. Leek RD, Harris AL. Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia. 2002, 7:177-89.
50. Esposito I, Menicagli M, Funel N. Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J Clin Pathol. 2004, 57:630-6.
51. Jackson JR, Seed MP, Kircher CH. The codependence of angiogenesis and chronic inflammation. FASEB J. 1997, 11:457-65.
52. Wagner EM, Sanchez J, McClintock JY. Inflammation and ischemia-induced lung angiogenesis. Am J Physiol Lung Cell Mol Physiol 2008, 294:L351-7.
53. Hunt TK, Knighton DR, Thakral KK. Studies on inflammation and wound healing: angiogenesis and collagen synthesis stimulated in vivo by resident and activated wound macrophages. Surgery. 1984, 96:48-54.
54. Buschmann IR, Hoefer IE, van Royen N. GM-CSF: a strong arteriogenic factor acting by amplification of monocyte function. Atherosclerosis. 2001, 159:343-56.
55. Heil M, Ziegelhoeffer T, Pipp F. Blood monocyte concentration is critical for enhancement of collateral artery growth. Am J Physiol Heart Circ Physiol 2002, 283:H2411-9.
56. Ito WD, Arras M, Winkler B. Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. Circ Res. 1997, 80:829-37.
57. Hirose N, Maeda H, Yamamoto M. The local injection of peritoneal macrophages induces neovascularization in rat ischemic hind limb muscles. Cell Transplant. 2008, 17:211-22.
58. Sasayama S, Fujita M. Recent insights into coronary collateral circulation. Circulation. 1992, 85:1197-204.
59. Krupinski J, Kaluza J, Kumar P. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke. 1994, 25:1794-8.
60. Herold J, Tillmanns H, Xing Z. Isolation and transduction of monocytes: promising vehicles for therapeutic arteriogenesis. Langenbecks Arch Surg. 2006, 391:72-82.
61. Gonzalez-Barderas M, Gallego-Delgado J, Mas S. Isolation of circulating human monocytes with high purity for proteomic analysis. Proteomics. 2004, 4:432-7.
62. de Almeida MC, Silva AC, Barral A. A simple method for human peripheral blood monocyte isolation. Mem Inst Oswaldo Cruz. 2000, 95:221-3.
63. Repnik U, Knezevic M, Jeras M. Simple and cost-effective isolation of monocytes from buffy coats. J Immunol Methods. 2003, 278:283-92.
64. Brichard B, Varis I, Latinne D. Intracellular cytokine profile of cord and adult blood monocytes. Bone Marrow Transplant. 2001, 27:1081-6.
65. Jin K, Zhu Y, Sun Y. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci USA. 2002, 99:11946-50.
66. Teng H, Zhang ZG, Wang L. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab. 2008, 28:764-71.
67. Ruhnke M, Ungefroren H, Nussler A. Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology. 2005, 128:1774-86.
68. Ruhnke M, Nussler AK, Ungefroren H. Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy. Transplantation. 2005, 79:1097-103.
69. Pufe T, Petersen W, Fandrich F. Programmable cells of monocytic origin (PCMO): a source of peripheral blood stem cells that generate collagen type II-producing chondrocytes. J Orthop Res. 2008, 26:304-13.
70. Dresske B, El Mokhtari NE, Ungefroren H. Multipotent cells of monocytic origin improve damaged heart function. Am J Transplant. 2006, 6:947-58.
71. Wisenberg G, Lekx K, Zabel P. Cell tracking and therapy evaluation of bone marrow monocytes and stromal cells using SPECT and CMR in a canine model of myocardial infarction. J Cardiovasc Magn Reson. 2009, 11:11.
72. Nasseri BA, Kukucka M, Dandel M. Intramyocardial delivery of bone marrow mononuclear cells and mechanical assist device implantation in patients with end-stage cardiomyopathy. Cell Transplant. 2007, 16:941-9.
73. Moelker AD, Baks T, van den Bos EJ. Reduction in infarct size, but no functional improvement after bone marrow cell administration in a porcine model of reperfused myocardial infarction. Eur Heart J. 2006, 27:3057-64.
74. Lunde K, Solheim S, Forfang K. Anterior myocardial infarction with acute percutaneous coronary intervention and intracoronary injection of autologous mononuclear bone marrow cells: safety, clinical outcome, and serial changes in left ventricular function during 12-months' follow-up. J Am Coll Cardiol. 2008, 51:674-6.
75. Willing AE, Lixian J, Milliken M. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res. 2003, 73:296-307.
76. Pimentel-Coelho PM, Magalhães ES, Lopes LM. Human cord blood transplantation in a neonatal rat model of hypoxic-ischemic brain damage: functional outcome related to neuroprotection in the striatum. Stem Cells Dev. 2009, 10.1089/scd.2009.0049, DOI
77. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005, 5:953-64.
78. Mielcarek M, Martin PJ, Torok-Storb B. Suppression of alloantigen-induced T-cell proliferation by CD14+ cells derived from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells. Blood. 1997, 89:1629-34.
79. Sorg RV, Andres S, Kogler G. Phenotypic and functional comparison of monocytes from cord blood and granulocyte colony-stimulating factor-mobilized apheresis products. Exp Hematol. 2001, 29:1289-94.
80. Mills KC, Gross TG, Varney ML. Immunologic phenotype and function in human bone marrow, blood stem cells and umbilical cord blood. Bone Marrow Transplant. 1996, 18:53-61.
81. Henning RJ, Burgos JD, Vasko M. Human cord blood cells and myocardial infarction: effect of dose and route of administration on infarct size. Cell Transplant. 2007, 16:907-17.
82. Chen J, Zhang ZG, Li Y. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res. 2003, 92:692-9.
83. Willing AE, Lixian J, Milliken M. Intravenous versus intrastriatal cord blood administration in a rodent model of stroke. J Neurosci Res. 2003, 73:296-307.
84. Newcomb JD, Sanberg PR, Klasko SK. Umbilical cord blood research: current and future perspectives. Cell Transplant. 2007, 16:151-8.
85. Chang YC, Shyu WC, Lin SZ. Regenerative therapy for stroke. Cell Transplant. 2007, 16:171-81.
86. Kinnaird T, Stabile E, Burnett MS. Bone-marrow-derived cells for enhancing collateral development: mechanisms, animal data, and initial clinical experiences. Circ Res. 2004, 95:354-63.
87. Norol F, Merlet P, Isnard R. Influence of mobilized stem cells on myocardial infarct repair in a nonhuman primate model. Blood. 2003, 102:4361-8.
88. Beeres SL, Bax JJ, Kaandorp TA. Usefulness of intramyocardial injection of autologous bone marrow-derived mononuclear cells in patients with severe angina pectoris and stress-induced myocardial ischemia. Am J Cardiol. 2006, 97:1326-31.
89. Tse HF, Thambar S, Kwong YL. Comparative evaluation of long-term clinical efficacy with catheter-based percutaneous intramyocardial autologous bone marrow cell implantation versus laser myocardial revascularization in patients with severe coronary artery disease. Am Heart J 2007, 154(982):e1-6.
90. Briguori C, Reimers B, Sarais C. Direct intramyocardial percutaneous delivery of autologous bone marrow in patients with refractory myocardial angina. Am Heart J. 2006, 151:674-80.
91. Losordo DW, Schatz RA, White CJ. Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial. Circulation. 2007, 115:3165-72.
92. van Ramshorst J, Bax JJ, Beeres SL. Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial. Jama. 2009, 301:1997-2004.
93. Taguchi A, Soma T, Tanaka H. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest. 2004, 114:330-8.
94. Laflamme MA, Zbinden S, Epstein SE. Cell-based therapy for myocardial ischemia and infarction: pathophysiological mechanisms. Annu Rev Pathol. 2007, 2:307-39.
95. Tse HF, Siu CW, Zhu SG. Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium. Eur J Heart Fail. 2007, 9:747-53.
96. Hossne NA, Invitti AL, Buffolo E. Intramyocardial injection of a specific formulation of autologous bone marrow stem cells as a sole therapy in patients with refratory angina, without left ventricular dysfunction: 18 month follow-up. Cell Transplant. 2009, 18:1299-310.
97. Jiang Q, Azuma E, Hirayama M. Functional immaturity of cord blood monocytes as detected by impaired response to hepatocyte growth factor. Pediatr Int. 2001, 43:334-9.
98. Theilgaard-Monch K, Raaschou-Jensen K, Palm H. Flow cytometric assessment of lymphocyte subsets, lymphoid progenitors, and hematopoietic stem cells in allogeneic stem cell grafts. Bone Marrow Transplant. 2001, 28:1073-82.
99. Liu E, Tu W, Law HK. Decreased yield, phenotypic expression and function of immature monocyte-derived dendritic cells in cord blood. Br J Haematol. 2001, 113:240-6.
100. Hill GR, Krenger W, Ferrara JL. The role of cytokines in acute graft-versus-host disease. Cytokines Cell Mol Ther. 1997, 3:257-66.
101. Gustafsson C, Mjosberg J, Matussek A. Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype. PLoS ONE 2008, 3:e2078.
102. Womble TA, Green S, Sanberg PR. CD14+ human umbilical cord blood cells are essential for neurological recovery following MCAO. Cell Transplant. 2008, 17:485-6.
103. Garbuzova-Davis S, Xie Y, Danias P. Transplantation of cord blood monocyte/ macrophage cells to treat Sanfilippo type B. Cell Transplant. 2008, 17:466-7.
104. Ma N, Stamm C, Kaminski A. Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-mice. Cardiovasc Res. 2005, 66:45-54.
105. Hu CH, Wu GF, Wang XQ. Transplanted human umbilical cord blood mononuclear cells improve left ventricular function through angiogenesis in myocardial infarction. Chin Med J (Engl). 2006, 119:1499-506.
106. Cortes-Morichetti M, Frati G, Schussler O. Association between a cell-seeded collagen matrix and cellular cardiomyoplasty for myocardial support and regeneration. Tissue Eng. 2007, 13:2681-7.
107. Vendrame M, Gemma C, de Mesquita D. Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells Dev. 2005, 14:595-604.
108. Bachstetter AD, Pabon MM, Cole MJ. Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain. BMC Neurosci 2008, 9:22.
109. Streit WJ, Walter SA, Pennell NA. Reactive microgliosis. Prog Neurobiol. 1999, 57:563-81.