Endocrine-committed progenitor cells retain their differentiation potential in the absence of neurogenin-3 expression

Biochemical and Biophysical Research Communications

Volumn 396, Issue 4, 2010, Pages 1036-1041

  Prasadan, Krishna ^a   Tulachan, Sidhartha ^a   Guo, Ping ^a   Shiota, Chiyo ^a   Shah, Sohail ^a   Gittes, George ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Duct cells; Neurogenin 3; Pancreas development; Progenitor cells; SOX9

Indexed keywords

GLUCAGON; INSULIN; NEUROGENIN 3; TRANSCRIPTION FACTOR SOX9;

ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; GESTATIONAL AGE; ORGANOGENESIS; PANCREAS DEVELOPMENT; PRIORITY JOURNAL; STEM CELL;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELLS, CULTURED; GLUCAGON; INSULIN; MICE; MICE, INBRED STRAINS; NERVE TISSUE PROTEINS; PANCREAS, EXOCRINE; PLANT LECTINS; RNA, SMALL INTERFERING; SOX9 TRANSCRIPTION FACTOR; STEM CELLS;

EID: 77953478928     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.05.058     Document Type: Article

References (25)

1. Ahlgren U., Jonsson J., Jonsson L., Simu K., and Edlund H. Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev. 12 (1998) 1763-1768
2. Kim S.K., and MacDonald R.J. Signaling and transcriptional control of pancreatic organogenesis. Curr. Opin. Genet. Dev. 12 (2002) 540-547
3. Offield M.F., Jetton T.L., Labosky P.A., Ray M., Stein R.W., Magnuson M.A., Hogan B.L., and Wright C.V. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122 (1996) 983-995
4. Artavanis-Tsakonas S., Rand M.D., and Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 284 (1999) 770-776
5. Jensen J., Pedersen E.E., Galante P., Hald J., Heller R.S., Ishibashi M., Kageyama R., Guillemot F., Serup P., and Madsen O.D. Control of endodermal endocrine development by Hes-1. Nat. Genet. 24 (2000) 36-44
6. Schonhoff S.E., Giel-Moloney M., and Leiter A.B. Minireview: development and differentiation of gut endocrine cells. Endocrinology 145 (2004) 2639-2644
7. Smith S.B., Watada H., and German M.S. Neurogenin3 activates the islet differentiation program while repressing its own expression. Mol. Endocrinol. 18 (2004) 142-149
8. Apelqvist A., Li H., Sommer L., Beatus P., Anderson D.J., Honjo T., Hrabe de Angelis M., Lendahl U., and Edlund H. Notch signalling controls pancreatic cell differentiation. Nature 400 (1999) 877-881
9. Lammert E., Brown J., and Melton D.A. Notch gene expression during pancreatic organogenesis. Mech. Dev. 94 (2000) 199-203
10. Johansson K.A., Dursun U., Jordan N., Gu G., Beermann F., Gradwohl G., and Grapin-Botton A. Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev. Cell 12 (2007) 457-465
11. Prasadan K., Daume E., Preuett B., Spilde T., Bhatia A., Kobayashi H., Hembree M., Manna P., and Gittes G.K. Glucagon is required for early insulin-positive differentiation in the developing mouse pancreas. Diabetes 51 (2002) 3229-3236
12. Gradwohl G., Dierich A., LeMeur M., and Guillemot F. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. USA 97 (2000) 1607-1611
13. Gu G., Dubauskaite J., and Melton D.A. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129 (2002) 2447-2457
14. Fujitani Y., Fujitani S., Boyer D.F., Gannon M., Kawaguchi Y., Ray M., Shiota M., Stein R.W., Magnuson M.A., and Wright C.V. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Develop. 20 (2006) 253-266
15. Seymour P.A., Freude K.K., Tran M.N., Mayes E.E., Jensen J., Kist R., Scherer G., and Sander M. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc. Natl. Acad. Sci. USA 104 (2007) 1865-1870
16. Seymour P.A., Freude K.K., Dubois C.L., Shih H.P., Patel N.A., and Sander M. A dosage-dependent requirement for SOX9 in pancreatic endocrine cell formation. Dev. Biol. 323 (2008) 19-30
17. Doyle M.J., Loomis Z.L., and Sussel L. Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development 134 (2007) 515-523
18. Sander M., Sussel L., Conners J., Scheel D., Kalamaras J., Dela Cruz F., Schwitzgebel V., Hayes-Jordan A., and German M. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development 127 (2000) 5533-5540
19. Prado C.L., Pugh-Bernard A.E., Elghazi L., Sosa-Pineda B., and Sussel L. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc. Natl. Acad. Sci. USA 101 (2004) 2924-2929
20. Kobayashi H., Spilde T., Li Z., Marosky J., Bhatia A., Hembree M., Prasadan K., Preuett B., and Gittes G. Lectin as a marker for staining and purification of embryonic pancreatic epithelium. Biochem. Biophys. Res. Commun. 293 (2002) 691-697
21. Schwitzgebel V.M., Scheel D.W., Conners J.R., Kalamaras J., Lee J.E., Anderson D.J., Sussel L., Johnson J.D., and German M.S. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127 (2000) 3533-3542
22. Villasenor A., Chong D.C., and Cleaver O. Biphasic Ngn3 expression in the developing pancreas. Dev. Dyn. 237 (2008) 3270-3279
23. Wang S., Jensen J.N., Seymour P.A., Hsu W., Dor Y., Sander M., Magnuson M.A., Serup P., and Gu G. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc. Natl. Acad. Sci. USA 106 (2009) 9715-9720
24. Collombat P., Xu X., Ravassard P., Sosa-Pineda B., Dussaud S., Billestrup N., Madsen O.D., Serup P., Heimberg H., and Mansouri A. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 138 (2009) 449-462
25. Norgaard G.A., Jensen J.N., and Jensen J. FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev. Biol. 264 (2003) 323-338