Pharmacodynamic modeling of acute and chronic effects of methylprednisolone on hepatic urea cycle genes in rats

Gene Regulation and Systems Biology

Volumn 2008, Issue 2, 2008, Pages 1-19

  Hazra, Anasuya ^a,b   DuBois, Debra C ^a   Almon, Richard R ^a   Synder, Grayson H ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b PFIZER INC   (United States)

Author keywords

Corticosteroids; Genomics; Methylprednisolone; Pharmacodynamics; Urea cycle

Indexed keywords

ALANINE AMINOTRANSFERASE; ARGINASE; ARGININOSUCCINATE SYNTHASE; ASPARTATE AMINOTRANSFERASE; CARBAMOYL PHOSPHATE SYNTHASE; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; GLUCOCORTICOID RECEPTOR; GLUTAMATE DEHYDROGENASE; METHYLPREDNISOLONE SODIUM SUCCINATE; ORNITHINE DECARBOXYLASE; TYROSINE AMINOTRANSFERASE;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MALE; MICROARRAY ANALYSIS; MOLECULAR EVOLUTION; NONHUMAN; PHARMACODYNAMICS; PHARMACOGENOMICS; QUANTITATIVE ANALYSIS; RAT; RECEPTOR BINDING; RNA EXTRACTION; SINGLE DRUG DOSE; UPREGULATION; UREA CYCLE;

RATTUS; RATTUS NORVEGICUS;

EID: 77953460086     PISSN: None     EISSN: 11776250     Source Type: Journal    
DOI: 10.1177/117762500800200001     Document Type: Article

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