Modeling of corticosteroid pharmacogenomics in rat liver using gene microarrays
J. Y. Jin, R. R. Almon, D. C. DuBois, and W. J. Jusko. Modeling of corticosteroid pharmacogenomics in rat liver using gene microarrays. J. Pharmacol. Exp. Ther. 307:93-109 (2003).
Fourth-generation model for corticosteroid pharmacodynamics: A model for methylprednisolone effects on receptor/gene-mediated glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver
Y. N. Sun, D. C. DuBois, R. R. Almon, and W. J. Jusko. Fourth-generation model for corticosteroid pharmacodynamics: a model for methylprednisolone effects on receptor/gene-mediated glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. J. Pharmacokinet. Biopharm. 26:289-317 (1998).
Pharmacokinetic/Pharmacodynamic models for corticosteroid receptor down-regulation and glutamine synthetase induction in rat skeletal muscle by a Receptor/Gene-mediated mechanism
Y. N. Sun, L. I. McKay, D. C. DuBois, W. J. Jusko, and R. R. Almon. Pharmacokinetic/Pharmacodynamic models for corticosteroid receptor down-regulation and glutamine synthetase induction in rat skeletal muscle by a Receptor/Gene-mediated mechanism. J. Pharmacol. Exp. Ther. 288:720-728 (1999).
Pharmacodynamics and pharmacogenomics of methylprednisolone during 7-day infusions in rats
R. Ramakrishnan, D. C. DuBois, R. R. Almon, N. A. Pyszczynski, and W. J. Jusko. Pharmacodynamics and pharmacogenomics of methylprednisolone during 7-day infusions in rats. J. Pharmacol. Exp. Ther. 300:245-256 (2002).
In vivo multi-tissue corticosteroid microarray time series available online at Public Expression Profile Resource (PEPR)
R. R. Almon, J. Chen, G. Snyder, D. C. DuBois, W. J. Jusko, and E. P. Hoffman. In vivo multi-tissue corticosteroid microarray time series available online at Public Expression Profile Resource (PEPR). Pharmacogenomics 4:791-799 (2003).
The genomic response of skeletal muscle to methylprednisolone using microarrays: Tailoring data mining to the structure of the pharmacogenomic time series
R. R. Almon, D. C. DuBois, W. H. Piel, and W. J. Jusko. The genomic response of skeletal muscle to methylprednisolone using microarrays: tailoring data mining to the structure of the pharmacogenomic time series. Pharmacogenomics 5:525-552 (2004).
Pharmacogenomic responses of rat liver to methylprednisolone: An approach to mining a rich microarray time series
R. R. Almon, D. C. Dubois, J. Y. Jin, and W. J. Jusko. Pharmacogenomic responses of rat liver to methylprednisolone: an approach to mining a rich microarray time series. Aaps J. 7:E156-E194 (2005).
Corticosteroid- regulated genes in rat kidney: Mining time series array data
R. R. Almon, W. Lai, D. C. DuBois, and W. J. Jusko. Corticosteroid- regulated genes in rat kidney: mining time series array data. Am. J. Physiol. 289:E870-E882 (2005).
Regulation of glucocorticoid receptor expression: Evidence for transcriptional and posttranslational mechanisms
Y. Dong, L. Poellinger, J. A. Gustafsson, and S. Okret. Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms. Mol. Endocrinol. 2:1256-1264 (1988).
D. Z. D'Argenio and A. Schumitzky. ADAPT II user's guide: pharmacokinetic/pharmacodynamic systems analysis software, Biomedical Simulation Resource, Los Angeles, 1997.