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Volumn 3, Issue 5, 2009, Pages 197-203

The increasing role of pharmacogenetics in the treatment of gastrointestinal cancers

Author keywords

[No Author keywords available]

Indexed keywords

5',3' NUCLEOTIDASE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARRIER PROTEIN; CETUXIMAB; CISPLATIN; CYTIDINE DEAMINASE; DEOXYCYTIDINE KINASE; DEOXYCYTIDINE PHOSPHATE DEAMINASE; DIHYDROPYRIMIDINE DEHYDROGENASE; DNA TOPOISOMERASE; DRUG RECEPTOR; ENZYME; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; GLUCURONOSYLTRANSFERASE 1A1; GLUTATHIONE TRANSFERASE; INTERLEUKIN 8; IRINOTECAN; MESSENGER RNA; OXALIPLATIN; PANITUMUMAB; RIBONUCLEOTIDE REDUCTASE; THYMIDYLATE PHOSPHORYLASE; THYMIDYLATE SYNTHASE; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 77953440835     PISSN: 19347820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (6)

References (65)
  • 2
    • 1342289079 scopus 로고    scopus 로고
    • Bi-weekly irinotecan (CPT-11) plus bolus 5-fluourouracl (5-FU) and folinic acid in patients with advanced stage colorectal cancer (ACRC)
    • Yalcin S, Oksuzoglu B, Tekuzman G, et al: Bi-weekly irinotecan (CPT-11) plus bolus 5-fluourouracl (5-FU) and folinic acid in patients with advanced stage colorectal cancer (ACRC). Jpn J Clin Oncol 33:580-583, 2003
    • (2003) Jpn J Clin Oncol , vol.33 , pp. 580-583
    • Yalcin, S.1    Oksuzoglu, B.2    Tekuzman, G.3
  • 3
    • 13944281278 scopus 로고    scopus 로고
    • Common etiology of capecitabine and fluorouracil-induced coronary vasospasm in a colon cancer patient. vasospasm in a colon cancer patient
    • Aksoy S, Karaca B, Dincer M, et al: Common etiology of capecitabine and fluorouracil-induced coronary vasospasm in a colon cancer patient. vasospasm in a colon cancer patient. Ann Pharmacother 39:573-574, 2005
    • (2005) Ann Pharmacother , vol.39 , pp. 573-574
    • Aksoy, S.1    Karaca, B.2    Dincer, M.3
  • 5
    • 0024523831 scopus 로고
    • Pharmacogenetic perspectives gained from twin and family studies
    • Vesell ES: Pharmacogenetic perspectives gained from twin and family studies. Pharmacol Ther 41:535-552, 1989
    • (1989) Pharmacol Ther , vol.41 , pp. 535-552
    • Vesell, E.S.1
  • 6
    • 0345596364 scopus 로고    scopus 로고
    • Toxicity of fluorouracil in patients with advanced colorectal cancer: Effect of administration schedule and prognostic factors. Meta-Analysis Group in Cancer
    • Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors. Meta-Analysis Group in Cancer. J Clin Oncol 16:3537-3541,1998
    • (1998) J Clin Oncol , vol.16 , pp. 3537-3541
  • 7
    • 0025666730 scopus 로고
    • Metabolism of pyrimidine analogues and their nucleosides
    • Daher GC, Harris BE, Diasio RB: Metabolism of pyrimidine analogues and their nucleosides. Pharmacol Ther 48:189-222, 1990
    • (1990) Pharmacol Ther , vol.48 , pp. 189-222
    • Daher, G.C.1    Harris, B.E.2    Diasio, R.B.3
  • 8
    • 0035234651 scopus 로고    scopus 로고
    • Clinical implications of dihydropyrimidine dehydrogenase on 5-FU pharmacology
    • Diasio RB: Clinical implications of dihydropyrimidine dehydrogenase on 5-FU pharmacology. Oncology 15:21-26, 2001
    • (2001) Oncology , vol.15 , pp. 21-26
    • Diasio, R.B.1
  • 9
    • 0027534425 scopus 로고
    • Dihydropyrimidine dehydrogenase activity in cancer patients
    • Fleming RA, Milano GA, Gaspard MH, et al: Dihydropyrimidine dehydrogenase activity in cancer patients. Eur J Cancer 29A:740-744, 1993
    • (1993) Eur J Cancer , vol.29 A , pp. 740-744
    • Fleming, R.A.1    Milano, G.A.2    Gaspard, M.H.3
  • 10
    • 0000163968 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity
    • Milano G, Etienne MC, Pierrefite V, et al: Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity. Br J Cancer 79:627-630, 1999
    • (1999) Br J Cancer , vol.79 , pp. 627-630
    • Milano, G.1    Etienne, M.C.2    Pierrefite, V.3
  • 11
    • 0032745499 scopus 로고    scopus 로고
    • Relationship between intratumoral dihydropyrimidine dehydrogenase activity and gene expression in human colorectal cancer
    • Uetake H, Ichikawa W, Takechi T, et al: Relationship between intratumoral dihydropyrimidine dehydrogenase activity and gene expression in human colorectal cancer. Clin Cancer Res 5:2836-2839, 1999
    • (1999) Clin Cancer Res , vol.5 , pp. 2836-2839
    • Uetake, H.1    Ichikawa, W.2    Takechi, T.3
  • 12
    • 0027426408 scopus 로고
    • Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics newly identified deficient patients and clinical implications in 5-fluorouracil in cancer patients
    • Lu Z, Zhang R, Diasio RB: Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics newly identified deficient patients and clinical implications in 5-fluorouracil in cancer patients. Cancer Res 53:5433-5438, 1993
    • (1993) Cancer Res , vol.53 , pp. 5433-5438
    • Lu, Z.1    Zhang, R.2    Diasio, R.B.3
  • 13
    • 0032143631 scopus 로고    scopus 로고
    • Characterization of the human dihydropyrimidine dehydrogenase gene
    • Wei X, Elizondo G, Sapone A, et al: Characterization of the human dihydropyrimidine dehydrogenase gene. Genomics 51:391-400, 1998
    • (1998) Genomics , vol.51 , pp. 391-400
    • Wei, X.1    Elizondo, G.2    Sapone, A.3
  • 14
    • 0036020649 scopus 로고    scopus 로고
    • Implications of di hydropyrimidine dehydrogenase on 5FU pharmacogenetics and pharmacogenomics
    • Mattison L, Soong R, Diasio R: Implications of di hydropyrimidine dehydrogenase on 5FU pharmacogenetics and pharmacogenomics. Pharmacogenomics 3:485-491, 2002
    • (2002) Pharmacogenomics , vol.3 , pp. 485-491
    • Mattison, L.1    Soong, R.2    Diasio, R.3
  • 15
    • 15144351973 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer
    • Ridge S, Sludden J, Wei X, et al: Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer. Br J Cancer 77:497, 1998
    • (1998) Br J Cancer , vol.77 , pp. 497
    • Ridge, S.1    Sludden, J.2    Wei, X.3
  • 16
    • 33847678481 scopus 로고    scopus 로고
    • Pharmacogenomics of cancer chemotherapy-induced toxicity
    • Miller CR, McLeod HL: Pharmacogenomics of cancer chemotherapy-induced toxicity. Support Oncol 5:9-14, 2007
    • (2007) Support Oncol , vol.5 , pp. 9-14
    • Miller, C.R.1    McLeod, H.L.2
  • 17
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston PG, Lenz HJ, Leichman CG, et al: Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 55(7): 1407-1412, 1995
    • (1995) Cancer Res , vol.55 , Issue.7 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3
  • 18
    • 17644373059 scopus 로고    scopus 로고
    • Variance in the expression of 5-fluorouracil pathway genes in colorectal cancer
    • Kidd EA, Yu J, Li X, et al: Variance in the expression of 5-fluorouracil pathway genes in colorectal cancer. Clin Cancer Res 11:2612-2619, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 2612-2619
    • Kidd, E.A.1    Yu, J.2    Li, X.3
  • 19
    • 0035750549 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
    • Pullarkat ST, Stoehlmacher J, Ghaderi V, et al: Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J 1:65-70, 2001
    • (2001) Pharmacogenomics J , vol.1 , pp. 65-70
    • Pullarkat, S.T.1    Stoehlmacher, J.2    Ghaderi, V.3
  • 20
    • 0035430487 scopus 로고    scopus 로고
    • Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
    • Marsh S, McKay JA, Cassidy J, et al: Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. Int J Oncol 19:383-386, 2001
    • (2001) Int J Oncol , vol.19 , pp. 383-386
    • Marsh, S.1    McKay, J.A.2    Cassidy, J.3
  • 21
    • 0034048729 scopus 로고    scopus 로고
    • Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyridine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
    • Salonga D, Danenberg KD, Johnson M, et al: Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyridine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 6:1322-1327, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 1322-1327
    • Salonga, D.1    Danenberg, K.D.2    Johnson, M.3
  • 22
    • 0035868667 scopus 로고    scopus 로고
    • Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer
    • Villafranca E, Okruzhnov Y, Dominguez MA, et al: Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol 19:1779-1786, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 1779-1786
    • Villafranca, E.1    Okruzhnov, Y.2    Dominguez, M.A.3
  • 23
    • 0031722179 scopus 로고    scopus 로고
    • High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil
    • Metzger R, Danenberg K, Leichman CG, et al: High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil. Clin Cancer Res 4:2371-2376, 1998
    • (1998) Clin Cancer Res , vol.4 , pp. 2371-2376
    • Metzger, R.1    Danenberg, K.2    Leichman, C.G.3
  • 24
    • 33748662632 scopus 로고    scopus 로고
    • Thymidine phosphorylase expression is associated with response to capecitabine plus irinotecan in patients with metastatic colorectal cancer
    • Meropol NJ, Gold PJ, Diasio RB, et al: Thymidine phosphorylase expression is associated with response to capecitabine plus irinotecan in patients with metastatic colorectal cancer. J Clin Oncol 24(25):4069-4077, 2006
    • (2006) J Clin Oncol , vol.24 , Issue.25 , pp. 4069-4077
    • Meropol, N.J.1    Gold, P.J.2    Diasio, R.B.3
  • 25
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA 3rd, Moore MJ, Andersen J, et al: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15(6): 2403-2413, 1997
    • (1997) J Clin Oncol , vol.15 , Issue.6 , pp. 2403-2413
    • Burris 3rd, H.A.1    Moore, M.J.2    Andersen, J.3
  • 26
    • 0028799108 scopus 로고
    • Gemcitabine: Metabolism, mechanisms of action, and selfpotentiation
    • Plunkett W, Huang P, Xu YZ, et al: Gemcitabine: metabolism, mechanisms of action, and selfpotentiation. Semin Oncol 22:3-10, 1995
    • (1995) Semin Oncol , vol.22 , pp. 3-10
    • Plunkett, W.1    Huang, P.2    Xu, Y.Z.3
  • 27
    • 0025295958 scopus 로고
    • Modulatory activity of 2?,2?-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides
    • Gandhi V, Plunkett W: Modulatory activity of 2?,2?-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. Cancer Res 50:3675-3680, 1990
    • (1990) Cancer Res , vol.50 , pp. 3675-3680
    • Gandhi, V.1    Plunkett, W.2
  • 28
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • Spratlin J, Sangha R, Glubrecht D, et al: The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 10:6956-6961, 2004
    • (2004) Clin Cancer Res , vol.10 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3
  • 29
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey JR, Mani RS, Selner M, et al: Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res 58:4349-4357, 1998
    • (1998) Cancer Res , vol.58 , pp. 4349-4357
    • Mackey, J.R.1    Mani, R.S.2    Selner, M.3
  • 30
    • 33646407273 scopus 로고    scopus 로고
    • Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: Relationship to molecular mechanisms of gemcitabine resistance and survival
    • Sebastiani V, Ricci F, Rubio-Viqueira B, et al: Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival. Clin Cancer Res 12:2492-2497, 2006
    • (2006) Clin Cancer Res , vol.12 , pp. 2492-2497
    • Sebastiani, V.1    Ricci, F.2    Rubio-Viqueira, B.3
  • 31
    • 33746042207 scopus 로고    scopus 로고
    • Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer
    • Giovannetti E, Mey V, Nannizzi S, et al: Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer. Mol Cancer Ther 5:1387-1395, 2006
    • (2006) Mol Cancer Ther , vol.5 , pp. 1387-1395
    • Giovannetti, E.1    Mey, V.2    Nannizzi, S.3
  • 32
    • 0036462584 scopus 로고    scopus 로고
    • Determinants of resistance to 2?,2?-difluorodeoxycytidine (gemcitabine)
    • Bergman AM, Pinedo HM, Peters GJ: Determinants of resistance to 2?,2?-difluorodeoxycytidine (gemcitabine). Drug Resist Update 5: 19-33, 2002
    • (2002) Drug Resist Update , vol.5 , pp. 19-33
    • Bergman, A.M.1    Pinedo, H.M.2    Peters, G.J.3
  • 33
    • 33745686698 scopus 로고    scopus 로고
    • Cellular pharmacology of gemcitabine
    • Mini E, Nobili S, Caciagli B, et al: Cellular pharmacology of gemcitabine. Ann Oncol 17 (suppl 5):v7-v12, 2006
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 5
    • Mini, E.1    Nobili, S.2    Caciagli, B.3
  • 34
    • 34447329337 scopus 로고    scopus 로고
    • Pharmacogenomics of gemcitabine: Can genetic studies lead to tailor-made therapy?
    • Ueno H, Kiyosawa K, Kaniwa N: Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy? Br J Cancer 97:145-151, 2007
    • (2007) Br J Cancer , vol.97 , pp. 145-151
    • Ueno, H.1    Kiyosawa, K.2    Kaniwa, N.3
  • 35
    • 20244364241 scopus 로고    scopus 로고
    • Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin
    • Yonemori K, Ueno H, Okusaka T, et al: Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin. Clin Cancer Res 11: 2620-2624, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 2620-2624
    • Yonemori, K.1    Ueno, H.2    Okusaka, T.3
  • 36
    • 33750579074 scopus 로고    scopus 로고
    • RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer
    • Bepler G, Kusmartseva I, Sharma S, et al: RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer. J Clin Oncol 24:4731-4737, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 4731-4737
    • Bepler, G.1    Kusmartseva, I.2    Sharma, S.3
  • 37
    • 0034892379 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)
    • Mathijssen RH, van Alphen RJ, Verweij J, et al: Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin Cancer Res 7:2182-2194, 2001
    • (2001) Clin Cancer Res , vol.7 , pp. 2182-2194
    • Mathijssen, R.H.1    van Alphen, R.J.2    Verweij, J.3
  • 38
    • 10044263002 scopus 로고    scopus 로고
    • Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38
    • Charasson V, Bellott R, Meynard D, et al: Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. Clin Pharmacol Ther 76:528-535, 2004
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 528-535
    • Charasson, V.1    Bellott, R.2    Meynard, D.3
  • 39
    • 0034282809 scopus 로고    scopus 로고
    • Proficient metabolism of irinotecan by a human intestinal carboylesterase
    • Khanna R, Morton C, Danks MK, et al: Proficient metabolism of irinotecan by a human intestinal carboylesterase. Cancer Res 60: 4725-4728, 2000
    • (2000) Cancer Res , vol.60 , pp. 4725-4728
    • Khanna, R.1    Morton, C.2    Danks, M.K.3
  • 40
    • 2342459714 scopus 로고    scopus 로고
    • Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
    • Innocenti F, Undevia SD, Iyer L, et al: Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 22:1382, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 1382
    • Innocenti, F.1    Undevia, S.D.2    Iyer, L.3
  • 41
    • 0036025450 scopus 로고    scopus 로고
    • UGT1A1*28 polimorphism as a determinant of irinotecan disposition and toxicity
    • Iyer L, Das S, Janisch L, et al: UGT1A1*28 polimorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J 2:43-47, 2002
    • (2002) Pharmacogenomics J , vol.2 , pp. 43-47
    • Iyer, L.1    Das, S.2    Janisch, L.3
  • 42
    • 34548598459 scopus 로고    scopus 로고
    • UGT1A1*28 genotype and irinotecan induced neutropenia: Dose matters
    • Hoskins J, Goldberg R, Qu P, et al: UGT1A1*28 genotype and irinotecan induced neutropenia: dose matters. J Natl Cancer Inst 99: 1290-1295, 2007
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1290-1295
    • Hoskins, J.1    Goldberg, R.2    Qu, P.3
  • 43
    • 0242442751 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of systemic toxicity and response after 5-fluorouracil (5FU)/CPT-11, 5FU/oxaliplatin (oxal), or CPT-11/oxal therapy for advanced colorectal cancer (CRC): Results from an intergroup trial
    • abstr 1013
    • McLeod, HL, Sargent DJ, Marsh S, et al: Pharmacogenetic analysis of systemic toxicity and response after 5-fluorouracil (5FU)/CPT-11, 5FU/oxaliplatin (oxal), or CPT-11/oxal therapy for advanced colorectal cancer (CRC): Results from an intergroup trial. Proc Am Soc Clin Oncol 22:2003 (abstr 1013)
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • McLeod, H.L.1    Sargent, D.J.2    Marsh, S.3
  • 44
    • 0021250007 scopus 로고
    • Pharmacokinetics of free and total platinum species after short infusion of cisplatin
    • Vermorken JB, van der Vijgh WJF, Klein I, et al: Pharmacokinetics of free and total platinum species after short infusion of cisplatin. Cancer Treat Rep 68:505-513, 1984
    • (1984) Cancer Treat Rep , vol.68 , pp. 505-513
    • Vermorken, J.B.1    van der Vijgh, W.J.F.2    Klein, I.3
  • 45
    • 0031864830 scopus 로고    scopus 로고
    • Oxaliplatin: Mechanism of action and antineoplastic activity
    • Raymond E, Faivre S, Woynarowski JM, et al: Oxaliplatin: mechanism of action and antineoplastic activity. Semin Oncol 25(2 suppl 5): 4-12, 1998
    • (1998) Semin Oncol , vol.25 , Issue.2 SUPPL. 5 , pp. 4-12
    • Raymond, E.1    Faivre, S.2    Woynarowski, J.M.3
  • 46
    • 0033959065 scopus 로고    scopus 로고
    • Oxaliplatin: Pharmacokinetics and chronopharmacological aspects
    • Levi F, Metzger G, Massari C, et al: Oxaliplatin: pharmacokinetics and chronopharmacological aspects. Clin Pharmacokinet 5:1-21, 2000
    • (2000) Clin Pharmacokinet , vol.5 , pp. 1-21
    • Levi, F.1    Metzger, G.2    Massari, C.3
  • 47
    • 34247105821 scopus 로고    scopus 로고
    • Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy
    • Ruzzo A, Graziano F, Loupakis F, et al: Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy. J Clin Oncol 25:1247-1254, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 1247-1254
    • Ruzzo, A.1    Graziano, F.2    Loupakis, F.3
  • 48
    • 3843130823 scopus 로고    scopus 로고
    • A multivariate analysis of genomic polymorphisms: Prediction of clinical outcome to 5-fluorouracil/ oxaliplatin combination chemotherapy in refractory colorectal cancer
    • Stoehlmacher J, Park DJ, Zhang W, et al: A multivariate analysis of genomic polymorphisms: Prediction of clinical outcome to 5-fluorouracil/ oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer 91:344-354, 2004
    • (2004) Br J Cancer , vol.91 , pp. 344-354
    • Stoehlmacher, J.1    Park, D.J.2    Zhang, W.3
  • 49
    • 77953450942 scopus 로고    scopus 로고
    • Goldberg RM, McLeod HL, Sargent DJ, et al: Genetic polymorphisms, toxicity, and response rate in African Americans (AA) with metastatic colorectal cancer (MCRC) compared to Caucasians (C) when treated with IFL, FOLFOX or IROX in Intergroup N9741. J Clin Oncol 24(18S June 20 suppl):2006 (abstr 3503)
    • Goldberg RM, McLeod HL, Sargent DJ, et al: Genetic polymorphisms, toxicity, and response rate in African Americans (AA) with metastatic colorectal cancer (MCRC) compared to Caucasians (C) when treated with IFL, FOLFOX or IROX in Intergroup N9741. J Clin Oncol 24(18S June 20 suppl):2006 (abstr 3503)
  • 50
    • 77953375293 scopus 로고    scopus 로고
    • Grothey A, McLeod HL, Green EM, et al: Glutathione S-transferase P1 I105V (GSTP1 I105V) polymorphism is associated with early onset of oxaliplatin-induced neurotoxicity. J Clin Oncol 23(16S June 1 suppl):2005 (abstr 3509)
    • Grothey A, McLeod HL, Green EM, et al: Glutathione S-transferase P1 I105V (GSTP1 I105V) polymorphism is associated with early onset of oxaliplatin-induced neurotoxicity. J Clin Oncol 23(16S June 1 suppl):2005 (abstr 3509)
  • 51
    • 24344479165 scopus 로고    scopus 로고
    • ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer
    • Viguier J, Boige V, Miquel C, et al: ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer. Clin Cancer Res 11:6212-6217, 2005
    • (2005) Clin Cancer Res , vol.11 , pp. 6212-6217
    • Viguier, J.1    Boige, V.2    Miquel, C.3
  • 52
    • 36348983120 scopus 로고    scopus 로고
    • Pharmacogenomic analysis of a randomized phase II trial (BOND 2) of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer
    • abstr 401
    • Lenz H, Zhang W, Yang D, et al: Pharmacogenomic analysis of a randomized phase II trial (BOND 2) of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. 2007 Gastrointestinal Cancers Symposium (abstr 401)
    • (2007) Gastrointestinal Cancers Symposium
    • Lenz, H.1    Zhang, W.2    Yang, D.3
  • 53
    • 77953469513 scopus 로고    scopus 로고
    • Zhang W, Vallböhmer D, Yang D, et al: Genomic profile associated with clinical outcome of EGFR-expressing metastatic colorectal cancer patients treated with epidermal growth factor receptor (EGFR) inhibitor cetuximab. J Clin Oncol 23(16S June 1 suppl):2005 (abstr 3557)
    • Zhang W, Vallböhmer D, Yang D, et al: Genomic profile associated with clinical outcome of EGFR-expressing metastatic colorectal cancer patients treated with epidermal growth factor receptor (EGFR) inhibitor cetuximab. J Clin Oncol 23(16S June 1 suppl):2005 (abstr 3557)
  • 54
    • 77953446204 scopus 로고    scopus 로고
    • Zhang W, Yang D, Capanu M, et al: Pharmacogenomic analysis of a randomized phase II trial (BOND 2) of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. J Clin Oncol 25(18S June 20 suppl):2007 (abstr 4128)
    • Zhang W, Yang D, Capanu M, et al: Pharmacogenomic analysis of a randomized phase II trial (BOND 2) of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. J Clin Oncol 25(18S June 20 suppl):2007 (abstr 4128)
  • 55
    • 77953471925 scopus 로고    scopus 로고
    • Van Cutsem E, Lang I, D'haens G, et al: KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience. J Clin Oncol 26(15S May 20 suppl):5s, 2008 (abstr 2)
    • Van Cutsem E, Lang I, D'haens G, et al: KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience. J Clin Oncol 26(15S May 20 suppl):5s, 2008 (abstr 2)
  • 56
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M, et al: Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26:1626-1634, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 57
    • 77953431972 scopus 로고    scopus 로고
    • Bokemeyer C, Bondarenko I, Hartmann J, et al: KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: The OPUS experience. J Clin Oncol 26(15S May 20 suppl):178s, 2008 (abstr 4000)
    • Bokemeyer C, Bondarenko I, Hartmann J, et al: KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: The OPUS experience. J Clin Oncol 26(15S May 20 suppl):178s, 2008 (abstr 4000)
  • 58
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F, Martini M, Molinari F, et al: Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 26:5705-5712, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 59
    • 77953388758 scopus 로고    scopus 로고
    • Di Fiore F, Van Cutsem E, Laurent-Puig P, et al: Role of KRAS mutation in predicting response, progression-free survival, and overall survival in irinotecan-refractory patients treated with cetuximab plus irinotecan for a metastatic colorectal cancer: analysis of 281 individual data from published series. J Clin Oncol 26(15S May 20 suppl):2008 (abstr 4035)
    • Di Fiore F, Van Cutsem E, Laurent-Puig P, et al: Role of KRAS mutation in predicting response, progression-free survival, and overall survival in irinotecan-refractory patients treated with cetuximab plus irinotecan for a metastatic colorectal cancer: analysis of 281 individual data from published series. J Clin Oncol 26(15S May 20 suppl):2008 (abstr 4035)
  • 60
    • 0035398631 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hidalgo M, Siu LL, Nemunaitis J, et al: Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 19:3267-3279, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 3267-3279
    • Hidalgo, M.1    Siu, L.L.2    Nemunaitis, J.3
  • 61
    • 34250694236 scopus 로고    scopus 로고
    • Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes
    • Li J, Zhao M, He P, et al: Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res 13:3731-3737, 2007
    • (2007) Clin Cancer Res , vol.13 , pp. 3731-3737
    • Li, J.1    Zhao, M.2    He, P.3
  • 62
    • 41949140593 scopus 로고    scopus 로고
    • Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity
    • Rudin CM, Liu W, Desai A, et al: Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity. J Clin Oncol 26:1119-1127, 2008
    • (2008) J Clin Oncol , vol.26 , pp. 1119-1127
    • Rudin, C.M.1    Liu, W.2    Desai, A.3
  • 63
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, et al: Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25:1960-1966, 2007
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 64
    • 77953379281 scopus 로고    scopus 로고
    • Moore MJ, da Cunha Santos G, Kamel-Reid S: The relationship of K-ras mutations and EGFR gene copy number to outcome in patients treated with erlotinib on National Cancer Institute of Canada Clinical Trials Group trial study PA.3. J Clin Oncol 25(18S June 20 suppl):2007 (abstr 4521)
    • Moore MJ, da Cunha Santos G, Kamel-Reid S: The relationship of K-ras mutations and EGFR gene copy number to outcome in patients treated with erlotinib on National Cancer Institute of Canada Clinical Trials Group trial study PA.3. J Clin Oncol 25(18S June 20 suppl):2007 (abstr 4521)
  • 65
    • 77953461144 scopus 로고    scopus 로고
    • Verslype C, Vervenne W, Bennouna J, et al: Rash as a marker for the efficacy of gemcitabine plus erlotinib-based therapy in pancreatic cancer: Results from the AViTA Study. Rash as a marker for the efficacy of gemcitabine plus erlotinibbased therapy in pancreatic cancer: Results from the AViTA Study. J Clin Oncol 27(15S suppl):2009 (abstr 4532)
    • Verslype C, Vervenne W, Bennouna J, et al: Rash as a marker for the efficacy of gemcitabine plus erlotinib-based therapy in pancreatic cancer: Results from the AViTA Study. Rash as a marker for the efficacy of gemcitabine plus erlotinibbased therapy in pancreatic cancer: Results from the AViTA Study. J Clin Oncol 27(15S suppl):2009 (abstr 4532)


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