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Volumn 15, Issue 3 PART B, 2010, Pages 529-535

Genotypic determinants and phenotypic properties of antiviral-resistant HBV variants: Insight from entecavir resistance studies

Author keywords

[No Author keywords available]

Indexed keywords

ADEFOVIR; EMTRICITABINE; ENTECAVIR; LAMIVUDINE; TELBIVUDINE; TENOFOVIR; ANTIVIRUS AGENT; GUANINE;

EID: 77953430954     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: 10.3851/IMP1504     Document Type: Review
Times cited : (15)

References (48)
  • 1
    • 45749088957 scopus 로고    scopus 로고
    • Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?
    • Soriano V, Perelson AS, Zoulim F. Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses? J Antimicrob Chemother 2008; 62:1-4.
    • (2008) J Antimicrob Chemother , vol.62 , pp. 1-4
    • Soriano, V.1    Perelson, A.S.2    Zoulim, F.3
  • 2
    • 33747095403 scopus 로고    scopus 로고
    • Antiviral drug resistance
    • Richman DD. Antiviral drug resistance. Antiviral Res 2006; 71:117-121.
    • (2006) Antiviral Res , vol.71 , pp. 117-121
    • Richman, D.D.1
  • 3
    • 70350095437 scopus 로고    scopus 로고
    • Hepatitis B virus resistance to nucleos(t)ide analogues
    • Zoulim F, Locarnini S. Hepatitis B virus resistance to nucleos(t)ide analogues. Gastroenterology 2009; 137:1593-1608.
    • (2009) Gastroenterology , vol.137 , pp. 1593-1608
    • Zoulim, F.1    Locarnini, S.2
  • 4
    • 0029815110 scopus 로고    scopus 로고
    • Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine
    • Ling R, Mutimer D, Ahmed M, et al. Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine. Hepatology 1996; 24:711-713.
    • (1996) Hepatology , vol.24 , pp. 711-713
    • Ling, R.1    Mutimer, D.2    Ahmed, M.3
  • 6
    • 0031037065 scopus 로고    scopus 로고
    • Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation
    • Bartholomew MM, Jansen RW, Jeffers LJ, et al. Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation. Lancet 1997; 349:20-22.
    • (1997) Lancet , vol.349 , pp. 20-22
    • Bartholomew, M.M.1    Jansen, R.W.2    Jeffers, L.J.3
  • 7
    • 0031780935 scopus 로고    scopus 로고
    • Identification and characterization of mutations in hepatitis B virus resistant to lamivudine
    • Lamivudine Clinical Investigation Group
    • Allen MI, Deslauriers M, Andrews CW, et al. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group. Hepatology 1998; 27:1670-1677.
    • (1998) Hepatology , vol.27 , pp. 1670-1677
    • Allen, M.I.1    Deslauriers, M.2    Andrews, C.W.3
  • 8
    • 0035041976 scopus 로고    scopus 로고
    • Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC)
    • Das K, Xiong X, Yang H, et al. Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC). J Virol 2001; 75:4771-4779.
    • (2001) J Virol , vol.75 , pp. 4771-4779
    • Das, K.1    Xiong, X.2    Yang, H.3
  • 9
    • 34447255407 scopus 로고    scopus 로고
    • The rtL80I substitution in the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro
    • Warner N, Locarnini S, Kuiper M, et al. The rtL80I substitution in the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro. Antimicrob Agents Chemother 2007; 51:2285-2292.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2285-2292
    • Warner, N.1    Locarnini, S.2    Kuiper, M.3
  • 10
    • 0142092372 scopus 로고    scopus 로고
    • The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro
    • Delaney WE, IV, Yang H, Westland CE, et al. The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. J Virol 2003; 77:11833-11841.
    • (2003) J Virol , vol.77 , pp. 11833-11841
    • Delaney IV, W.E.1    Yang, H.2    Westland, C.E.3
  • 11
    • 0031938029 scopus 로고    scopus 로고
    • Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective
    • Melegari M, Scaglioni PP, Wands JR. Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. Hepatology 1998; 27:628-633.
    • (1998) Hepatology , vol.27 , pp. 628-633
    • Melegari, M.1    Scaglioni, P.P.2    Wands, J.R.3
  • 12
    • 0037443950 scopus 로고    scopus 로고
    • Prevalence and clinical correlates of YMDD variants during lamivudine therapy for patients with chronic hepatitis B
    • Lai CL, Dienstag J, Schiff E, et al. Prevalence and clinical correlates of YMDD variants during lamivudine therapy for patients with chronic hepatitis B. Clin Infect Dis 2003; 36:687-696.
    • (2003) Clin Infect Dis , vol.36 , pp. 687-696
    • Lai, C.L.1    Dienstag, J.2    Schiff, E.3
  • 13
    • 58149459587 scopus 로고    scopus 로고
    • Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir
    • Seifer M, Patty A, Serra I, Li B, Standring DN. Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir. Antiviral Res 2009; 81:147-155.
    • (2009) Antiviral Res , vol.81 , pp. 147-155
    • Seifer, M.1    Patty, A.2    Serra, I.3    Li, B.4    Standring, D.N.5
  • 14
    • 17944372114 scopus 로고    scopus 로고
    • In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D- 2,6-diaminopurine dioxolane and 2′-fluoro-5-methyl- beta-L- arabinofuranosyluracil
    • Chin R, Shaw T, Torresi J, et al. In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D- 2,6-diaminopurine dioxolane and 2′-fluoro-5-methyl-beta-L- arabinofuranosyluracil. Antimicrob Agents Chemother 2001; 45:2495-2501.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2495-2501
    • Chin, R.1    Shaw, T.2    Torresi, J.3
  • 15
    • 33750588091 scopus 로고    scopus 로고
    • Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif
    • Yatsuji H, Noguchi C, Hiraga N, et al. Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif. Antimicrob Agents Chemother 2006; 50:3867-3874.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 3867-3874
    • Yatsuji, H.1    Noguchi, C.2    Hiraga, N.3
  • 16
    • 41249103028 scopus 로고    scopus 로고
    • Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure
    • Villet S, Pichoud C, Billioud G, et al. Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure. J Hepatol 2008; 48:747-755.
    • (2008) J Hepatol , vol.48 , pp. 747-755
    • Villet, S.1    Pichoud, C.2    Billioud, G.3
  • 17
    • 0035997941 scopus 로고    scopus 로고
    • Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine
    • Tatti KM, Korba BE, Stang HL, et al. Mutations in the conserved woodchuck hepatitis virus polymerase FLLA and YMDD regions conferring resistance to lamivudine. Antiviral Res 2002; 55:141-150.
    • (2002) Antiviral Res , vol.55 , pp. 141-150
    • Tatti, K.M.1    Korba, B.E.2    Stang, H.L.3
  • 18
    • 33644818518 scopus 로고    scopus 로고
    • A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    • Chang TT, Gish RG, de Man R, et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med 2006; 354:1001-1010.
    • (2006) N Engl J Med , vol.354 , pp. 1001-1010
    • Chang, T.T.1    Gish, R.G.2    De Man, R.3
  • 19
    • 33644822860 scopus 로고    scopus 로고
    • Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
    • Lai CL, Shouval D, Lok AS, et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2006; 354:1011-1020.
    • (2006) N Engl J Med , vol.354 , pp. 1011-1020
    • Lai, C.L.1    Shouval, D.2    Lok, A.S.3
  • 21
    • 26844500312 scopus 로고    scopus 로고
    • A dose-ranging study of the efficacy and tolerability of entecavir in lamivudine-refractory chronic hepatitis B patients
    • Chang TT, Gish RG, Hadziyannis SJ, et al. A dose-ranging study of the efficacy and tolerability of entecavir in lamivudine-refractory chronic hepatitis B patients. Gastroenterology 2005; 129:1198-1209.
    • (2005) Gastroenterology , vol.129 , pp. 1198-1209
    • Chang, T.T.1    Gish, R.G.2    Hadziyannis, S.J.3
  • 22
    • 33847683844 scopus 로고    scopus 로고
    • Two-year assessment of entecavir resistance in lamivudine-refractory hepatitis B virus patients reveals different clinical outcomes depending on the resistance substitutions present
    • Tenney DJ, Rose RE, Baldick CJ, et al. Two-year assessment of entecavir resistance in lamivudine-refractory hepatitis B virus patients reveals different clinical outcomes depending on the resistance substitutions present. Antimicrob Agents Chemother 2007; 51:902-911.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 902-911
    • Tenney, D.J.1    Rose, R.E.2    Baldick, C.J.3
  • 23
    • 66149115173 scopus 로고    scopus 로고
    • Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy
    • Tenney DJ, Rose RE, Baldick CJ, et al. Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy. Hepatology 2009; 49:1503-1514.
    • (2009) Hepatology , vol.49 , pp. 1503-1514
    • Tenney, D.J.1    Rose, R.E.2    Baldick, C.J.3
  • 24
    • 70350133508 scopus 로고    scopus 로고
    • Entecavir maintains a high genetic barrier to HBV resistance through 6 years in naive patients
    • Tenney DJ, Pokornowski KA, Rose RE, et al. Entecavir maintains a high genetic barrier to HBV resistance through 6 years in naive patients. J Hepatol 2009; 50:S10-S10.
    • (2009) J Hepatol , vol.50
    • Tenney, D.J.1    Pokornowski, K.A.2    Rose, R.E.3
  • 25
    • 38749126832 scopus 로고    scopus 로고
    • Virologic monitoring of hepatitis B virus therapy in clinical trials and practice: Recommendations for a standardized approach
    • Pawlotsky JM, Dusheiko G, Hatzakis A, et al. Virologic monitoring of hepatitis B virus therapy in clinical trials and practice: recommendations for a standardized approach. Gastroenterology 2008; 134:405-415.
    • (2008) Gastroenterology , vol.134 , pp. 405-415
    • Pawlotsky, J.M.1    Dusheiko, G.2    Hatzakis, A.3
  • 26
    • 45549103065 scopus 로고    scopus 로고
    • Entecavir at five years shows long-term maintenance of high genetic barrier to hepatitis B virus resistance
    • Tenney D, Pokornowski K, Rose R, et al. Entecavir at five years shows long-term maintenance of high genetic barrier to hepatitis B virus resistance. Hepatol Int 2008; 2:A88-A89.
    • (2008) Hepatol Int , vol.2
    • Tenney, D.1    Pokornowski, K.2    Rose, R.3
  • 27
    • 0028987482 scopus 로고
    • Mutations in the epsilon sequences of human hepatitis B virus affect both RNA encapsidation and reverse transcription
    • Fallows DA, Goff SP. Mutations in the epsilon sequences of human hepatitis B virus affect both RNA encapsidation and reverse transcription. J Virol 1995; 69:3067-3073.
    • (1995) J Virol , vol.69 , pp. 3067-3073
    • Fallows, D.A.1    Goff, S.P.2
  • 28
    • 4344627233 scopus 로고    scopus 로고
    • Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to lamivudine
    • Tenney DJ, Levine SM, Rose RE, et al. Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to lamivudine. Antimicrob Agents Chemother 2004; 48:3498-3507.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3498-3507
    • Tenney, D.J.1    Levine, S.M.2    Rose, R.E.3
  • 29
    • 0344304757 scopus 로고    scopus 로고
    • In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector
    • Yang H, Westland C, Xiong S, Delaney WE, IV. In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector. Antiviral Res 2004; 61:27-36.
    • (2004) Antiviral Res , vol.61 , pp. 27-36
    • Yang, H.1    Westland, C.2    Xiong, S.3    Delaney IV, W.E.4
  • 30
    • 4644323573 scopus 로고    scopus 로고
    • A new strategy for studying in vitro the drug susceptibility of clinical isolates of human hepatitis B virus
    • Durantel D, Carrouee-Durantel S, Werle-Lapostolle B, et al. A new strategy for studying in vitro the drug susceptibility of clinical isolates of human hepatitis B virus. Hepatology 2004; 40:855-864.
    • (2004) Hepatology , vol.40 , pp. 855-864
    • Durantel, D.1    Carrouee-Durantel, S.2    Werle-Lapostolle, B.3
  • 31
    • 43049174567 scopus 로고    scopus 로고
    • Hepatitis B virus quasispecies susceptibility to entecavir confirms the relationship between genotypic resistance and patient virologic response
    • Baldick CJ, Eggers BJ, Fang J, et al. Hepatitis B virus quasispecies susceptibility to entecavir confirms the relationship between genotypic resistance and patient virologic response. J Hepatol 2008; 48:895-902.
    • (2008) J Hepatol , vol.48 , pp. 895-902
    • Baldick, C.J.1    Eggers, B.J.2    Fang, J.3
  • 32
    • 34247107229 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus polymerase by entecavir
    • Langley DR, Walsh AW, Baldick CJ, et al. Inhibition of hepatitis B virus polymerase by entecavir. J Virol 2007; 81:3992-4001.
    • (2007) J Virol , vol.81 , pp. 3992-4001
    • Langley, D.R.1    Walsh, A.W.2    Baldick, C.J.3
  • 33
    • 0023727192 scopus 로고
    • Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions
    • Sells MA, Zelent AZ, Shvartsman M, Acs G. Replicative intermediates of hepatitis B virus in HepG2 cells that produce infectious virions. J Virol 1988; 62:2836-2844.
    • (1988) J Virol , vol.62 , pp. 2836-2844
    • Sells, M.A.1    Zelent, A.Z.2    Shvartsman, M.3    Acs, G.4
  • 34
    • 0030842540 scopus 로고    scopus 로고
    • Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: A novel system for screening potential inhibitors of HBV replication
    • Ladner SK, Otto MJ, Barker CS, et al. Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication. Antimicrob Agents Chemother 1997; 41:1715-1720.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1715-1720
    • Ladner, S.K.1    Otto, M.J.2    Barker, C.S.3
  • 35
    • 0031684393 scopus 로고    scopus 로고
    • Hepatitis B virus replication in human HepG2 cells mediated by hepatitis B virus recombinant baculovirus
    • DOI 10.1002/hep.510280432
    • Delaney WE, IV, Isom HC. Hepatitis B virus replication in human HepG2 cells mediated by hepatitis B virus recombinant baculovirus. Hepatology 1998; 28:1134-1146. (Pubitemid 28450278)
    • (1998) Hepatology , vol.28 , Issue.4 , pp. 1134-1146
    • Delaney IV, W.E.1    Isom, H.C.2
  • 37
    • 0031925585 scopus 로고    scopus 로고
    • Generation of replication-competent hepatitis B virus nucleocapsids in insect cells
    • Seifer M, Hamatake R, Bifano M, Standring DN. Generation of replication-competent hepatitis B virus nucleocapsids in insect cells. J Virol 1998; 72:2765-2776. (Pubitemid 28175513)
    • (1998) Journal of Virology , vol.72 , Issue.4 , pp. 2765-2776
    • Seifer, M.1    Hamatake, R.2    Bifano, M.3    Standring, D.N.4
  • 38
    • 0031761652 scopus 로고    scopus 로고
    • In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir
    • Seifer M, Hamatake RK, Colonno RJ, Standring DN. In vitro Inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir. Antimicrob Agents Chemother 1998; 42:3200-3208. (Pubitemid 28553742)
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , Issue.12 , pp. 3200-3208
    • Seifer, M.1    Hamatake, R.K.2    Colonno, R.J.3    Standring, D.N.4
  • 39
    • 43949100366 scopus 로고    scopus 로고
    • Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance
    • Baldick CJ, Tenney DJ, Mazzucco CE, et al. Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance. Hepatology 2008; 47:1473-1482.
    • (2008) Hepatology , vol.47 , pp. 1473-1482
    • Baldick, C.J.1    Tenney, D.J.2    Mazzucco, C.E.3
  • 40
    • 67649963336 scopus 로고    scopus 로고
    • Ultrasensitive genotypic detection of antiviral resistance in hepatitis B virus clinical isolates
    • Fang J, Wichroski MJ, Levine SM, et al. Ultrasensitive genotypic detection of antiviral resistance in hepatitis B virus clinical isolates. Antimicrob Agents Chemother 2009; 53:2762-2772.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2762-2772
    • Fang, J.1    Wichroski, M.J.2    Levine, S.M.3
  • 42
    • 65049086668 scopus 로고    scopus 로고
    • Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B
    • Kobashi H, Fujioka S, Kawaguchi M, et al. Two cases of development of entecavir resistance during entecavir treatment for nucleoside-naive chronic hepatitis B. Hepatol Int 2009; 3:403-410.
    • (2009) Hepatol Int , vol.3 , pp. 403-410
    • Kobashi, H.1    Fujioka, S.2    Kawaguchi, M.3
  • 43
    • 77949454516 scopus 로고    scopus 로고
    • Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir
    • Walsh AW, Langley DR, Colonno RJ, Tenney DJ. Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir. PLoS One 2010; 5:e9195.
    • (2010) PLoS One , vol.5
    • Walsh, A.W.1    Langley, D.R.2    Colonno, R.J.3    Tenney, D.J.4
  • 44
    • 0032573488 scopus 로고    scopus 로고
    • Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
    • Huang H, Chopra R, Verdine GL, Harrison SC. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 1998; 282:1669-1675. (Pubitemid 28549275)
    • (1998) Science , vol.282 , Issue.5394 , pp. 1669-1675
    • Huang, H.1    Chopra, R.2    Verdine, G.L.3    Harrison, S.C.4
  • 46
    • 33846785216 scopus 로고    scopus 로고
    • Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient
    • DOI 10.1016/j.jhep.2006.11.016, PII S0168827806006659
    • Villet S, Ollivet A, Pichoud C, et al. Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient. J Hepatol 2007; 46:531-538. (Pubitemid 46201724)
    • (2007) Journal of Hepatology , vol.46 , Issue.3 , pp. 531-538
    • Villet, S.1    Ollivet, A.2    Pichoud, C.3    Barraud, L.4    Villeneuve, J.-P.5    Trepo, C.6    Zoulim, F.7
  • 48
    • 2342433984 scopus 로고    scopus 로고
    • Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations
    • Bartholomeusz A, Tehan BG, Chalmers DK. Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations. Antivir Ther 2004; 9:149-160. (Pubitemid 38560208)
    • (2004) Antiviral Therapy , vol.9 , Issue.2 , pp. 149-160
    • Bartholomeusz, A.1    Tehan, B.G.2    Chalmers, D.K.3


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