Epithelial-mesenchymal transition modulates P-glucoprotein-induced multidrug resistance in breast cancer MCF-7 cells via p38-MAPK

Chinese Journal of Cancer Biotherapy

Volumn 17, Issue 2, 2010, Pages 144-148

  Tang, Yong ^a   Wang, Hui ^b   Chen, Wei Juan ^b   Li, Wen Tong ^b   Li, Hong Li ^b   Zhao, Xiu Shi ^b  

^a WEIFANG PEOPLE'S HOSPITAL   (China)

^b WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Breast neoplasms; Epithelial mesenchymal transition( EMT ); Multidrug resistance( MDR ); P glucoprotein( P gp ); Snail gene

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIDRUG RESISTANCE PROTEIN 1; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN;

ARTICLE; BREAST CANCER; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 77953400885     PISSN: 1007385X     EISSN: None     Source Type: Journal    
DOI: 10.3872/j.issn.1007-385X.2010.02.006     Document Type: Article

References (20)

1. Abaan OD, Mutlu PK, Baran Y, Atalay C, Gunduz U. Multidrug resistance mediated by MRP1 gene overexpression in breast cancer patients [J]. Cancer Invest, 2009, 27(2): 201-205.
2. Nakai E, Park K, Yawata T, Chihara T, Kumazawa A, Nakabayashi H, et al. Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma [J]. Cancer Invest, 2009, 27(9): 901-908.
3. Li QQ, Xu JD, Wang WJ, Cao XX, Chen Q, Tang F, et al. Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells [J]. Clin Cancer Res, 2009, 15(8): 2657-2665.
4. Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression [J]. Curr Opin Cell Biol, 2005, 17(5): 548-558. (Pubitemid 41267170)
5. Kang Y, Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis [J]. Cell, 2004, 118(3): 277-279. (Pubitemid 39061108)
6. Lundgren K, Nordenskjöld B, Landberg G. Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer [J]. Br J Cancer, 2009, 101(10): 1769-1781.
7. Kimura Y, Matsuo M, Takahashi K, Saeki T, Kioka N, Amachi T, et al. ATP hydrolysis-dependent multidrug efflux transporter: MDR1/P-glycoprotein [J]. Curr Drug Metab, 2004, 5(1): 1-10.
8. Hackett NR, El Sawy T, Lee LY, Silva I, O'Leary J, Rosengart TK, et al. Use of quantitative TaqMan real-time PCR to track the time-dependent distribution of gene transfer vectors in vivo [J]. Mol Ther, 2000, 2(6): 649-656.
9. Kang EM, Hanazano Y, Frare P, Vanin EF, De Witte M, Metzger M, et al. Persistent low-level engraftment of rhesus peripheral blood progenitor cells transduced with the fanconi anemia C gene after conditioning with low-dose irradiation [J]. Mol Ther, 2001, 3(6): 911-919.
10. Uchiyama-Kokubu N, Watanabe T. Establishment and characterization of adriamycin-resistant human colorectal adenocarcinoma HCT-15 cell line with multidrug resistance [J]. Anticancer Drugs, 2001, 12(9): 769-779.
11. Geiger TR, Peeper DS. Metastasis mechanisms [J]. Biochim Biophys Acta, 2009, 1796(2): 293-308.
12. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease [J]. Cell, 2009, 139(5): 871-890.
13. Nooter K, Stoter G. Molecular mechanisms of multidrug resistance in cancer chemotherapy [J]. Pathol Res Pract, 1996, 192(7): 768-780.
14. Arumugam T, Ramachandran V, Fournier KF, Wang H, Marquis L, Abbruzzese JL, et al. Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer [J]. Cancer Res, 2009, 69(14): 5820-5828.
15. Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3 kinase/AKT pathway [J]. Oncogene, 2005, 24(50): 7443-7454.
16. Massoumi R, Kuphal S, Hellerbrand C, Haas B, Wild P, Spruss T, et al. Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma [J]. J Exp Med, 2009, 206(1): 221-232.
17. Zhuo W, Wang Y, Zhuo X, Zhang Y, Ao X, Chen Z. Knockdown of Snail, a novel zinc finger transcription factor, via RNA interference increases A549 cell sensitivity to cisplatin via JNK/mitochondrial pathway [J]. Lung Cancer, 2008, 62(1): 8-14.
18. Davies M, Robinson M, Smith E, Huntley S, Prime S, Paterson I. Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta involves MAPK, Smad and AP-1 signalling pathways [J]. J Cell Biochem, 2005, 95(5): 918-931.
19. Guo X, Ma N, Wang J, Song J, Bu X, Cheng Y, et al. Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells [J]. BMC Cancer, 2008, 8(1): 375-384.