Multidrug resistance mediated by MRP1 gene overexpression in breast cancer patients

Cancer Investigation

Volumn 27, Issue 2, 2009, Pages 201-205

  Abaan, Ogan Demir ^a,b   Mutlu, Pelin Kaya ^a   Baran, Yusuf ^a,c   Atalay, Can ^a,d   Gunduz, Ufuk ^a  

^a MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

^b GEORGETOWN UNIVERSITY   (United States)

^c IZMIR INSTITUTE OF TECHNOLOGY   (Turkey)

^d ANKARA ONCOLOGY HOSPITAL   (Turkey)

Author keywords

Breast cancer; Chemotherapy; MDR; MRP Family; MRP1; Multidrug resistance

Indexed keywords

MULTIDRUG RESISTANCE PROTEIN 1;

ARTICLE; BREAST CANCER; CANCER PATIENT; CONTROLLED STUDY; DENSITOMETRY; GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MRP1 GENE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BETA 2-MICROGLOBULIN; BREAST NEOPLASMS; CELL LINE, TUMOR; DENSITOMETRY; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS;

EID: 60849098201     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900802173562     Document Type: Article

References (19)

1. Paul, D.; Cowan, K.H. Drug resistance in breast cancer. In Breast Cancer Molecular Genetics, Pathogenesis, and Therapeutics. Totowa (NJ): Humana Pres; 481-517.
2. Cole, S.P.; Bhardwaj, G.; Gerlach, J.H.; Mackie, J.E.; Grant, C.E.; Almquist, K.C.; Stewart, A.J.; Kurz, E.H.; Duncan, A.M.; Deeley, R.G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992, 5088, 1650-1654.
3. Cole, S.P.C.; Sparks, K.E.; Fraser, K.; Loe, D.W.; Grant, C.E.; Wilson, G.M.; Deeley, R.G. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 1994, 54, 5902-5910.
4. Tammur, J.; Prades, C.; Arnould, I.; Rzhetsky, A.; Hutchinson, A.; Adachi, M.; Schuetz, J.D.; Swoboda, K.J.; Ptacek, L.J.; Rosier, M.; Dean, M.; Allikmets, R. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 AND ABCC12, tandemly duplicated on chromosome 16q12. Gene 2001, 273, 89-96.
5. Hollo, Z.; Homolya, L.; Hegedus, T.; Sarkadi, B. Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells. FEBS Letters 1996, 383, 99-104.
6. Gaudiano, G.; Koch, T.H.; Lo Bello, M.; Nuccetelli, M.; Ravagnan, G.; Serafino, A.; Sinibaldi-Vallebona, P. Lack of glutathione conjugation to adriamycin in human breast cancer MCF-7/DOX cells. Bioch Pharm 2000, 60, 1915-1923.
7. Nooter, K.; Westerman, A.M.; Flens, M.J.; Zaman, G.J.; Scheper, R.J.; van Wingerden, K.E.; Burger, H.; Oostrum, R.; Boersma, T.; Sonneveld, P. Expression of the multidrug resistance-associated protein (MRP) gene in human cancers. Clin Cancer Res 1995, 1, 1301-1310.
8. Grant, C.E.; Valdirmarsson, G.; Hipfner, D.R.; Almquist, K.C.; Cole, S.P.; Deeley, R.G.; Rapid, R.N.A. isolation without the use of commercial kits: application to small tissue samples Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 1994, 54, 357-361.
9. Gauthier, E.R.; MadisonSD, Michel RN. Rapid RNA isolation without the use of commercial kits: application to small tissue samples, Europ J Physiology 1997, 433, 664-668.
10. Ferrero, J.M.; Etienne, M.C.; Formento, J.L.; Francoual, M.; Rostagno, P.; Peyrottes, I.; Ettore, F.; Teissier, E.; Leblanc-Talent, P.; Namer, M.; Milano, G. Application of an original RT-PCRELISA multiplex assay for MDR1 and MRP, along with p53 determination in node-positive breast cancer patients. Br J Cancer 2000, 82, 171-177.
11. Dexter, D.W.; Reddy, R.K.; Geles, K.G.; Bansal, S.; Myint, M.A.; Rogakto, A.; Leighton, J.C.; Goldstein LJ. Quantitative reverse transcriptase-polymerase chain reaction measured expression of MDR1 and MRP in primary breast carcinoma. Clin Cancer Res 1998, 4, 1533-1542.
12. Baran, Y.; Ural, A.U.; Gunduz, U. Cross-Resistance To Cytosine Arabinoside in Human Acute Myeloid Leukemia Cells Selected for Resistance to Vincristine. Exp Oncol 2006, 28, 163-165.
13. Baran, Y.; Gur, B.; Kaya, P.; Ural, A.U.; Avcu, F.; Gunduz, U. Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance." Hemat 2007, 12(6), 511-517.
14. Wada, H.; Saikawa, Y.; Niida, Y.; Nishimura R.; Noguchi, T.; Matsukawa, H.; Ichihara, T.; Koizumi, S. Selectively induced high MRP gene expression in multidrug-resistant human HL60 leukemia cells. Exp Hemat 1999, 27, 99-109.
15. Zheng, H.; Chen Z-S, Belinsky, M.G.; et al: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: Effect of polyglutamylation on MTX transport. Cancer Res 2001, 61, 7225-7232.
16. Goldhirsch, A.; Wood, W.C.; Gelber, R.D.; et al. Meeting highlights: Updated international expert consensus on the primary therapy of early breast cancer. J Clin Oncol 2003, 21, 3357-3365.
17. Rudas, M.; Filipits, M.; Taucher, S.; Stranzl, T.; Steger, G.G.; Jakesz, R.; Pirker, R.; and Pohl, G. Expression of MRP1, LRP and Pgp in breast carcinoma patients treated with preoperative chemotherapy. Breast Cancer Res Treat 2003, 81, 149-157.
18. Leonessa, F., Clarke, R. ATP binding cassette transporters and drug resistance in breast cancer. Endocr Relat Cancer 2003, 10, 43-73.
19. Trock, B.J.; Leonessa F.; and Clarke, R. Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance. J Natl Cancer Inst 1997, 89, 917-931.