메뉴 건너뛰기




Volumn 1, Issue 3, 2009, Pages 167-181

Review: Beyond KRAS: Perspectives on new potential markers of intrinsic and acquired resistance to epidermal growth factor receptor inhibitors in metastatic colorectal cancer

Author keywords

cetuximab; colorectal cancer; epidermal growth factor receptor; panitumumab; predictive factors

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; GEFITINIB; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; VANDETANIB; VASCULOTROPIN;

EID: 77953367684     PISSN: 17588340     EISSN: None     Source Type: Journal    
DOI: 10.1177/1758834009348984     Document Type: Review
Times cited : (6)

References (88)
  • 1
    • 60849087350 scopus 로고    scopus 로고
    • (2009) K-Ras mutations and cetuximab in colorectal cancer
    • Albitar, M., Yeh, C. and Ma, W. (2009) K-Ras mutations and cetuximab in colorectal cancer. N Engl J Med 360: 834.
    • N Engl J Med , vol.360 , pp. 834
    • Albitar, M.1    Yeh, C.2    Ma, W.3
  • 2
    • 65349189958 scopus 로고    scopus 로고
    • (2009) American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • Allegra, C.J., Jessup, J.M., Somerfield, M.R., Hamilton, S.R., Hammond, E.H., Hayes, D.F. et al. (2009) American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol 27: 2091-2096.
    • J Clin Oncol , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3    Hamilton, S.R.4    Hammond, E.H.5    Hayes, D.F.6
  • 3
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado, R.G., Wolf, M., Peeters, M., van Cutsem, E., Siena, S., Freeman, D.J. et al. (2008) Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26: 1626-1634.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3    van Cutsem, E.4    Siena, S.5    Freeman, D.J.6
  • 4
    • 10844264628 scopus 로고    scopus 로고
    • An epidermal growth factor receptor intron 1 polymoprhism mediates response to epidermal growth factor receptor inhibitors
    • Amador, M., Oppenheimer, D., Perea, S. and Maitra, A. ( 2004) An epidermal growth factor receptor intron 1 polymoprhism mediates response to epidermal growth factor receptor inhibitors. Cancer Res 64: 9139-9143.
    • (2004) Cancer Res , vol.64 , pp. 9139-9143
    • Amador, M.1    Oppenheimer, D.2    Perea, S.3    Maitra, A.4
  • 5
    • 0035444798 scopus 로고    scopus 로고
    • Kirsten RAS mutations in patients with colorectal cancer: the ‘Rascal II’ study
    • Andreyev, H.J., Norman, A.R., Cunningham, D., Oates, J., Dix, B.R., Iacopetta, B.J. et al. (2001) Kirsten RAS mutations in patients with colorectal cancer: the ‘Rascal II’ study. Br J Cancer 85: 692-696.
    • (2001) Br J Cancer , vol.85 , pp. 692-696
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3    Oates, J.4    Dix, B.R.5    Iacopetta, B.J.6
  • 7
    • 3042785708 scopus 로고    scopus 로고
    • Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections
    • Atkins, D., Reiffen, K.A., Tegtmeier, C.L., Winther, H., Bonato, M.S. and Storkel, S. ( 2004) Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections. J Histochem Cytochem 52: 893-901.
    • (2004) J Histochem Cytochem , vol.52 , pp. 893-901
    • Atkins, D.1    Reiffen, K.A.2    Tegtmeier, C.L.3    Winther, H.4    Bonato, M.S.5    Storkel, S.6
  • 8
    • 63449122814 scopus 로고    scopus 로고
    • (2009) Establishment and characterization of a model of acquired resistance to epidermal growth factor receptor targeting agents in human cancer cells
    • Benavente, S., Huang, S., Armstrong, E.A., Chi, A., Hsu, K.T., Wheeler, D.L. et al. (2009) Establishment and characterization of a model of acquired resistance to epidermal growth factor receptor targeting agents in human cancer cells. Clin Cancer Res 15: 1585-1592.
    • Clin Cancer Res , vol.15 , pp. 1585-1592
    • Benavente, S.1    Huang, S.2    Armstrong, E.A.3    Chi, A.4    Hsu, K.T.5    Wheeler, D.L.6
  • 9
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • Benvenuti, S., Sartore-Bianchi, A., Di Nicolantonio, F., Zanon, C., Moroni, M., Veronese, S. et al. (2007) Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 67: 2643-2648.
    • (2007) Cancer Res , vol.67 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Zanon, C.4    Moroni, M.5    Veronese, S.6
  • 10
    • 40349108627 scopus 로고    scopus 로고
    • Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs
    • Bianco, R., Garofalo, S., Rosa, R., Damiano, V., Gelardi, T., Daniele, G. et al. (2008) Inhibition of mTOR pathway by everolimus cooperates with EGFR inhibitors in human tumours sensitive and resistant to anti-EGFR drugs. Br J Cancer 98: 923-930.
    • (2008) Br J Cancer , vol.98 , pp. 923-930
    • Bianco, R.1    Garofalo, S.2    Rosa, R.3    Damiano, V.4    Gelardi, T.5    Daniele, G.6
  • 11
    • 52649143725 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
    • Bianco, R., Rosa, R., Damiano, V., Daniele, G., Gelardi, T., Garofalo, S. et al. (2008) Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells. Clin Cancer Res 14: 5069-5080.
    • (2008) Clin Cancer Res , vol.14 , pp. 5069-5080
    • Bianco, R.1    Rosa, R.2    Damiano, V.3    Daniele, G.4    Gelardi, T.5    Garofalo, S.6
  • 12
    • 61449239114 scopus 로고    scopus 로고
    • (2009) Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
    • Bibeau, F., Lopez-Crapez, E., Di Fiore, F., Thezenas, S., Ychou, M., Blanchard, F. et al. (2009) Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J Clin Oncol 27: 1122-1129.
    • J Clin Oncol , vol.27 , pp. 1122-1129
    • Bibeau, F.1    Lopez-Crapez, E.2    Di Fiore, F.3    Thezenas, S.4    Ychou, M.5    Blanchard, F.6
  • 13
    • 0033583220 scopus 로고    scopus 로고
    • C-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr 845 and Tyr 1101 is associated with modulation of receptor function
    • Biscardi, J.S., Maa, M.C., Tice, D.A., Cox, M.E., Leu, T.H. and Parsons, S.J. ( 1999) C-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr 845 and Tyr 1101 is associated with modulation of receptor function. J Biol Chem 274: 8335-8343.
    • (1999) J Biol Chem , vol.274 , pp. 8335-8343
    • Biscardi, J.S.1    Maa, M.C.2    Tice, D.A.3    Cox, M.E.4    Leu, T.H.5    Parsons, S.J.6
  • 14
    • 59949091448 scopus 로고    scopus 로고
    • (2009) Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer, C., Bondarenko, I., Makhson, A., Hartmann, J.T., Aparicio, J., de Braud, F. et al. (2009) Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 27: 663-671.
    • J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3    Hartmann, J.T.4    Aparicio, J.5    de Braud, F.6
  • 15
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
    • Bruns, C.J., Solorzano, C.C., Harbison, M.T., Ozawa, S., Tsan, R., Fan, D. et al. (2000) Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 60: 2926-2935.
    • (2000) Cancer Res , vol.60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3    Ozawa, S.4    Tsan, R.5    Fan, D.6
  • 16
    • 36749036721 scopus 로고    scopus 로고
    • Transformation efficiency of RASq 61 mutants linked to structural features of the switch regions in the presence of RAF
    • Buhrman, G., Wink, G. and Mattos, C. ( 2007) Transformation efficiency of RASq 61 mutants linked to structural features of the switch regions in the presence of RAF. Structure 15: 1618-1629.
    • (2007) Structure , vol.15 , pp. 1618-1629
    • Buhrman, G.1    Wink, G.2    Mattos, C.3
  • 17
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti, A., Loeffler, J.S. and Dyson, N.J. ( 2002) Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 62: 200-207.
    • (2002) Cancer Res , vol.62 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 18
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung, K.Y., Shia, J., Kemeny, N.E., Shah, M., Schwartz, G.K., Tse, A. et al. (2005) Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 23: 1803-1810.
    • (2005) J Clin Oncol , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3    Shah, M.4    Schwartz, G.K.5    Tse, A.6
  • 19
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor activity of Zd6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy
    • Ciardiello, F., Bianco, R., Caputo, R., Damiano, V., Troiani, T., Melisi, D. et al. (2004) Antitumor activity of Zd6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res 10: 784-793.
    • (2004) Clin Cancer Res , vol.10 , pp. 784-793
    • Ciardiello, F.1    Bianco, R.2    Caputo, R.3    Damiano, V.4    Troiani, T.5    Melisi, D.6
  • 20
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C 225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human geo colon cancer cells
    • Ciardiello, F., Bianco, R., Damiano, V., Fontanini, G., Caputo, R., Pomatico, G. et al. (2000) Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C 225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human geo colon cancer cells. Clin Cancer Res 6: 3739-3747.
    • (2000) Clin Cancer Res , vol.6 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3    Fontanini, G.4    Caputo, R.5    Pomatico, G.6
  • 21
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham, D., Humblet, Y., Siena, S., Khayat, D., Bleiberg, H., Santoro, A. et al. (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351: 337-345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 22
    • 61449258442 scopus 로고    scopus 로고
    • (2009) K-RAS mutations and cetuximab in colorectal cancer
    • de Roock, W., Lambrechts, D. and Tejpar, S. (2009) K-RAS mutations and cetuximab in colorectal cancer. N Engl J Med 360: 834.
    • N Engl J Med , vol.360 , pp. 834
    • de Roock, W.1    Lambrechts, D.2    Tejpar, S.3
  • 23
    • 40149088765 scopus 로고    scopus 로고
    • KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
    • de Roock, W., Piessevaux, H., de Schutter, J., Janssens, M., de Hertogh, G., Personeni, N. et al. (2007) KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol 19: 508-515.
    • (2007) Ann Oncol , vol.19 , pp. 508-515
    • de Roock, W.1    Piessevaux, H.2    de Schutter, J.3    Janssens, M.4    de Hertogh, G.5    Personeni, N.6
  • 24
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy
    • Di Fiore, F., Blanchard, F., Charbonnier, F., Le Pessot, F., Lamy, A., Galais, M.P. et al. (2007) Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy. Br J Cancer 96: 1166-1169.
    • (2007) Br J Cancer , vol.96 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3    Le Pessot, F.4    Lamy, A.5    Galais, M.P.6
  • 25
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio, F., Martini, M., Molinari, F., Sartore-Bianchi, A., Arena, S., Saletti, P. et al. (2008) Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 26: 5705-5712.
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3    Sartore-Bianchi, A.4    Arena, S.5    Saletti, P.6
  • 27
    • 0038394537 scopus 로고    scopus 로고
    • Acyclic N-(azacycloalkyl) bisindolylmaleimides: isozyme selective inhibitors of PKCbeta
    • Faul, M.M., Gillig, J.R., Jirousek, M.R., Ballas, L.M., Schotten, T., Kahl, A. et al. (2003) Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta. Bioorg Med Chem Lett 13: 1857-1859.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1857-1859
    • Faul, M.M.1    Gillig, J.R.2    Jirousek, M.R.3    Ballas, L.M.4    Schotten, T.5    Kahl, A.6
  • 28
    • 35348908314 scopus 로고    scopus 로고
    • PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
    • Frattini, M., Saletti, P., Romagnani, E., Martin, V., Molinari, F., Ghisletta, M. et al. (2007) PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer 97: 1139-1145.
    • (2007) Br J Cancer , vol.97 , pp. 1139-1145
    • Frattini, M.1    Saletti, P.2    Romagnani, E.3    Martin, V.4    Molinari, F.5    Ghisletta, M.6
  • 29
    • 65549143792 scopus 로고    scopus 로고
    • (2009) The importance of KRAS mutations and EGF61A > G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer
    • Garm Spindler, K.L., Pallisgaard, N., Rasmussen, A.A., Lindebjerg, J., Andersen, R.F., Cruger, D. et al. (2009) The importance of KRAS mutations and EGF61A > G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer. Ann Oncol 20: 879-884.
    • Ann Oncol , vol.20 , pp. 879-884
    • Garm Spindler, K.L.1    Pallisgaard, N.2    Rasmussen, A.A.3    Lindebjerg, J.4    Andersen, R.F.5    Cruger, D.6
  • 30
    • 0040886242 scopus 로고    scopus 로고
    • Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1
    • Gebhardt, F., Zanker, K.S. and Brandt, B. ( 1999) Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1. J Biol Chem 274: 13176-13180.
    • (1999) J Biol Chem , vol.274 , pp. 13176-13180
    • Gebhardt, F.1    Zanker, K.S.2    Brandt, B.3
  • 31
    • 48349117187 scopus 로고    scopus 로고
    • Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs
    • Gelardi, T., Caputo, R., Damiano, V., Daniele, G., Pepe, S., Ciardiello, F. et al. (2008) Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR drugs. Br J Cancer 99: 473-480.
    • (2008) Br J Cancer , vol.99 , pp. 473-480
    • Gelardi, T.1    Caputo, R.2    Damiano, V.3    Daniele, G.4    Pepe, S.5    Ciardiello, F.6
  • 32
    • 2342504508 scopus 로고    scopus 로고
    • Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers
    • Goel, A., Arnold, C., Niedzwiecki, D., Care thers, J., Dowell, J., Wasserman, L. et al. (2004) Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res 64: 3014-3021.
    • (2004) Cancer Res , vol.64 , pp. 3014-3021
    • Goel, A.1    Arnold, C.2    Niedzwiecki, D.3    Care thers, J.4    Dowell, J.5    Wasserman, L.6
  • 33
    • 41149140325 scopus 로고    scopus 로고
    • Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer
    • Graziano, F., Ruzzo, A., Loupakis, F., Canestrari, E., Santini, D., Catalano, V. et al. (2008) Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer. J Clin Oncol 26: 1427-1434.
    • (2008) J Clin Oncol , vol.26 , pp. 1427-1434
    • Graziano, F.1    Ruzzo, A.2    Loupakis, F.3    Canestrari, E.4    Santini, D.5    Catalano, V.6
  • 34
    • 33748146468 scopus 로고    scopus 로고
    • Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer
    • Hebbar, M., Wacrenier, A., Desauw, C., Romano, O., Cattan, S., Triboulet, J.P. et al. (2006) Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer. Anticancer Drugs 17: 855-857.
    • (2006) Anticancer Drugs , vol.17 , pp. 855-857
    • Hebbar, M.1    Wacrenier, A.2    Desauw, C.3    Romano, O.4    Cattan, S.5    Triboulet, J.P.6
  • 35
    • 59949102930 scopus 로고    scopus 로고
    • (2009) A randomized phase IIIb trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht, J.R., Mitchell, E., Chidiac, T., Scroggin, C., Hagenstad, C., Spigel, D. et al. (2009) A randomized phase IIIb trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 27: 672-680.
    • J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3    Scroggin, C.4    Hagenstad, C.5    Spigel, D.6
  • 36
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy
    • Herbst, R.S. and Shin, D.M. ( 2002) Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 94: 1593-1611.
    • (2002) Cancer , vol.94 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 37
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W. et al. (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350: 2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 38
    • 40949135397 scopus 로고    scopus 로고
    • PIK3ca mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
    • Jhawer, M., Goel, S., Wilson, A.J., Montagna, C., Ling, Y.H., Byun, D.S. et al. (2008) PIK3ca mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res 68: 1953-1961.
    • (2008) Cancer Res , vol.68 , pp. 1953-1961
    • Jhawer, M.1    Goel, S.2    Wilson, A.J.3    Montagna, C.4    Ling, Y.H.5    Byun, D.S.6
  • 39
    • 61449154484 scopus 로고    scopus 로고
    • (2009) KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection
    • Jimeno, A., Messersmith, W.A., Hirsch, F.R., Franklin, W.A. and Eckhardt, S.G. (2009) KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. J Clin Oncol 27: 1130-1136.
    • J Clin Oncol , vol.27 , pp. 1130-1136
    • Jimeno, A.1    Messersmith, W.A.2    Hirsch, F.R.3    Franklin, W.A.4    Eckhardt, S.G.5
  • 42
    • 33846564399 scopus 로고    scopus 로고
    • Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma
    • Kawaguchi, Y., Kono, K., Mimura, K., Sugai, H., Akaike, H. and Fujii, H. ( 2007) Cetuximab induce antibody-dependent cellular cytotoxicity against EGFR-expressing esophageal squamous cell carcinoma. Int J Cancer 120: 781-787.
    • (2007) Int J Cancer , vol.120 , pp. 781-787
    • Kawaguchi, Y.1    Kono, K.2    Mimura, K.3    Sugai, H.4    Akaike, H.5    Fujii, H.6
  • 43
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-RAS mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford, S., Garrett, C.R., Meropol, N.J., Basik, M., Harbison, C.T., Wu, S. et al. (2007) Expression of epiregulin and amphiregulin and K-RAS mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 25: 3230-3237.
    • (2007) J Clin Oncol , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3    Basik, M.4    Harbison, C.T.5    Wu, S.6
  • 44
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre, A., Bachet, J.B., Boige, V., Cayre, A., Le Corre, D., Buc, E. et al. (2008) KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 26: 374-379.
    • (2008) J Clin Oncol , vol.26 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3    Cayre, A.4    Le Corre, D.5    Buc, E.6
  • 45
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre, A., Bachet, J.B., Le Corre, D., Boige, V., Landi, B., Emile, J.F. et al. (2006) KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 66: 3992-3995.
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3    Boige, V.4    Landi, B.5    Emile, J.F.6
  • 46
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic K-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • Linardou, H., Dahabreh, I., Kanaloupiti, D., Siannis, F., Bafaloukos, D., Kosmidis, P. et al. (2008) Assessment of somatic K-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol 9: 962-972.
    • (2008) Lancet Oncol , vol.9 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.2    Kanaloupiti, D.3    Siannis, F.4    Bafaloukos, D.5    Kosmidis, P.6
  • 47
    • 66849140563 scopus 로고    scopus 로고
    • (2009) PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
    • Loupakis, F., Pollina, L., Stasi, I., Ruzzo, A., Scartozzi, M., Santini, D. et al. (2009) PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J Clin Oncol 27: 2622-2629.
    • J Clin Oncol , vol.27 , pp. 2622-2629
    • Loupakis, F.1    Pollina, L.2    Stasi, I.3    Ruzzo, A.4    Scartozzi, M.5    Santini, D.6
  • 48
    • 0030995078 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to modulation of 5-fluorouracil by leucovorin in HCT-8 human ileocecal carcinoma cells
    • Lu, K., Mcguire, J.J., Slocum, H.K. and Rustum, Y.M. ( 1997) Mechanisms of acquired resistance to modulation of 5-fluorouracil by leucovorin in HCT-8 human ileocecal carcinoma cells. Biochem Pharmacol 53: 689-696.
    • (1997) Biochem Pharmacol , vol.53 , pp. 689-696
    • Lu, K.1    Mcguire, J.J.2    Slocum, H.K.3    Rustum, Y.M.4
  • 49
    • 59449091688 scopus 로고    scopus 로고
    • Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-RAS in metastatic colorectal cancer patients treated with single-agent cetuximab
    • Lurje, G., Nagashima, F., Zhang, W., Yang, D., Chang, H.M., Gordon, M.A. et al. (2008) Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-RAS in metastatic colorectal cancer patients treated with single-agent cetuximab. Clin Cancer Res 14: 7884-7895.
    • (2008) Clin Cancer Res , vol.14 , pp. 7884-7895
    • Lurje, G.1    Nagashima, F.2    Zhang, W.3    Yang, D.4    Chang, H.M.5    Gordon, M.A.6
  • 50
    • 0028043510 scopus 로고
    • A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling
    • Moriai, T., Kobrin, M.S., Hope, C., Speck, L. and Korc, M. ( 1994) A variant epidermal growth factor receptor exhibits altered type alpha transforming growth factor binding and transmembrane signaling. Proc Natl Acad Sci U S A 91: 10217-10221.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10217-10221
    • Moriai, T.1    Kobrin, M.S.2    Hope, C.3    Speck, L.4    Korc, M.5
  • 51
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
    • Moroni, M., Veronese, S., Benvenuti, S., Marrapese, G., Sartore-Bianchi, A., Di Nicolantonio, F. et al. (2005) Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 6: 279-286.
    • (2005) Lancet Oncol , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3    Marrapese, G.4    Sartore-Bianchi, A.5    Di Nicolantonio, F.6
  • 52
    • 4644245701 scopus 로고    scopus 로고
    • Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IGGL is independent of FcgammarIIIa functional polymorphism
    • Niwa, R., Hatanaka, S., Shoji-Hosaka, E., Sakurada, M., Kobayashi, Y., Uehara, A. et al. (2004) Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IGGL is independent of FcgammarIIIa functional polymorphism. Clin Cancer Res 10: 6248-6255.
    • (2004) Clin Cancer Res , vol.10 , pp. 6248-6255
    • Niwa, R.1    Hatanaka, S.2    Shoji-Hosaka, E.3    Sakurada, M.4    Kobayashi, Y.5    Uehara, A.6
  • 53
    • 65349149003 scopus 로고    scopus 로고
    • (2009) Tp 53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy
    • Oden-Gangloff, A., Di Fiore, F., Bibeau, F., Lamy, A., Bougeard, G., Charbonnier, F. et al. (2009) Tp 53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy. Br J Cancer 100: 1330-1335.
    • Br J Cancer , vol.100 , pp. 1330-1335
    • Oden-Gangloff, A.1    Di Fiore, F.2    Bibeau, F.3    Lamy, A.4    Bougeard, G.5    Charbonnier, F.6
  • 54
    • 23844497341 scopus 로고    scopus 로고
    • Sensitive sequencing method for KRAS mutation detection by pyrosequencing
    • Ogino, S., Kawasaki, T., Brahmandam, M., Yan, L., Cantor, M., Namgyal, C. et al. (2005) Sensitive sequencing method for KRAS mutation detection by pyrosequencing. J Mol Diagn 7: 413-421.
    • (2005) J Mol Diagn , vol.7 , pp. 413-421
    • Ogino, S.1    Kawasaki, T.2    Brahmandam, M.3    Yan, L.4    Cantor, M.5    Namgyal, C.6
  • 55
    • 63049111794 scopus 로고    scopus 로고
    • (2009) PIK3ca mutation is associated with poor prognosis among patients with curatively resected colon cancer
    • Ogino, S., Nosho, K., Kirkner, G.J., Shima, K., Irahara, N., Kure, S. et al. (2009) PIK3ca mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol 27: 1477-1484.
    • J Clin Oncol , vol.27 , pp. 1477-1484
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3    Shima, K.4    Irahara, N.5    Kure, S.6
  • 56
    • 59049089201 scopus 로고    scopus 로고
    • PI3KCA/ PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
    • Perrone, F., Lampis, A., Orsenigo, M., Di Bartolomeo, M., Gevorgyan, A., Losa, M. et al. (2008) PI3KCA/ PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol 20: 84-90.
    • (2008) Ann Oncol , vol.20 , pp. 84-90
    • Perrone, F.1    Lampis, A.2    Orsenigo, M.3    Di Bartolomeo, M.4    Gevorgyan, A.5    Losa, M.6
  • 57
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C 225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • Perrotte, P., Matsumoto, T., Inoue, K., Kuniyasu, H., Eve, B.Y., Hicklin, D.J. et al. (1999) Anti-epidermal growth factor receptor antibody C 225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 5: 257-265.
    • (1999) Clin Cancer Res , vol.5 , pp. 257-265
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3    Kuniyasu, H.4    Eve, B.Y.5    Hicklin, D.J.6
  • 58
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ERBB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors
    • Petit, A.M., Rak, J., Hung, M.C., Rockwell, P., Goldstein, N., Fendly, B. et al. (1997) Neutralizing antibodies against epidermal growth factor and ERBB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 151: 1523-1530.
    • (1997) Am J Pathol , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3    Rockwell, P.4    Goldstein, N.5    Fendly, B.6
  • 59
    • 0030800922 scopus 로고    scopus 로고
    • MDM2: keeping P 53 under control
    • Piette, J., Neel, H. and Marechal, V. ( 1997) MDM2: keeping P 53 under control. Oncogene 15: 1001-1010.
    • (1997) Oncogene , vol.15 , pp. 1001-1010
    • Piette, J.1    Neel, H.2    Marechal, V.3
  • 61
    • 65649086786 scopus 로고    scopus 로고
    • (2009) PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer
    • Prenen, H., de Schutter, J., Jacobs, B., de Roock, W., Biesmans, B., Claes, B. et al. (2009) PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. Clin Cancer Res 15: 3184-3188.
    • Clin Cancer Res , vol.15 , pp. 3184-3188
    • Prenen, H.1    de Schutter, J.2    Jacobs, B.3    de Roock, W.4    Biesmans, B.5    Claes, B.6
  • 64
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the bond-2 study
    • Saltz, L.B., Lenz, H.J., Kindler, H.L., Hochster, H.S., Wadler, S., Hoff, P.M. et al. (2007) Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the bond-2 study. J Clin Oncol 25: 4557-4561.
    • (2007) J Clin Oncol , vol.25 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.J.2    Kindler, H.L.3    Hochster, H.S.4    Wadler, S.5    Hoff, P.M.6
  • 65
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S. et al. (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3    Silliman, N.4    Ptak, J.5    Szabo, S.6
  • 66
    • 62449302407 scopus 로고    scopus 로고
    • (2009) PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • Sartore-Bianchi, A., Martini, M., Molinari, F., Veronese, S., Nichelatti, M., Artale, S. et al. (2009) PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 69: 1851-1857.
    • Cancer Res , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3    Veronese, S.4    Nichelatti, M.5    Artale, S.6
  • 67
    • 34548258303 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
    • Sartore-Bianchi, A., Moroni, M., Veronese, S., Carnaghi, C., Bajetta, E., Luppi, G. et al. (2007) Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J Clin Oncol 25: 3238-3245.
    • (2007) J Clin Oncol , vol.25 , pp. 3238-3245
    • Sartore-Bianchi, A.1    Moroni, M.2    Veronese, S.3    Carnaghi, C.4    Bajetta, E.5    Luppi, G.6
  • 68
    • 16544377303 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies
    • Scartozzi, M., Bearzi, I., Berardi, R., Mandolesi, A., Fabris, G. and Cascinu, S. ( 2004) Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies. J Clin Oncol 22: 4772-4778.
    • (2004) J Clin Oncol , vol.22 , pp. 4772-4778
    • Scartozzi, M.1    Bearzi, I.2    Berardi, R.3    Mandolesi, A.4    Fabris, G.5    Cascinu, S.6
  • 69
    • 0037006414 scopus 로고    scopus 로고
    • Association between functional polymorphism in EGF gene and malignant melanoma
    • Shahbazi, M., Pravica, V., Nasreen, N., Fakhoury, H., Fryer, A.A., Strange, R.C. et al. (2002) Association between functional polymorphism in EGF gene and malignant melanoma. Lancet 359: 397-401.
    • (2002) Lancet , vol.359 , pp. 397-401
    • Shahbazi, M.1    Pravica, V.2    Nasreen, N.3    Fakhoury, H.4    Fryer, A.A.5    Strange, R.C.6
  • 70
    • 48649092117 scopus 로고    scopus 로고
    • High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer
    • Simi, L., Pratesi, N., Vignoli, M., Sestini, R., Cianchi, F., Valanzano, R. et al. (2008) High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer. Am J Clin Pathol 130: 247-253.
    • (2008) Am J Clin Pathol , vol.130 , pp. 247-253
    • Simi, L.1    Pratesi, N.2    Vignoli, M.3    Sestini, R.4    Cianchi, F.5    Valanzano, R.6
  • 71
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero, A.F., Maurel, J., Fehrenbacher, L., Scheithauer, W., Abubakr, Y.A., Lutz, M.P. et al. (2008) EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 26: 2311-2319.
    • (2008) J Clin Oncol , vol.26 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3    Scheithauer, W.4    Abubakr, Y.A.5    Lutz, M.P.6
  • 72
    • 57449105336 scopus 로고    scopus 로고
    • High amphiregulin and epiregulin expression in KRAS wild type colorectal primaries predicts response and survival benefit after treatment with cetuximab and irinotecan for metastatic disease
    • Tejpar, S., de Roock, W., Biesmans, B., de Schutter, J., Piessevaux, H., Humblet, Y. et al. (2008) High amphiregulin and epiregulin expression in KRAS wild type colorectal primaries predicts response and survival benefit after treatment with cetuximab and irinotecan for metastatic disease. Proceedings 2008 Gastrointestinal Cancers Symposium Abstr. 411.
    • (2008) Proceedings 2008 Gastrointestinal Cancers Symposium Abstr , vol.411
    • Tejpar, S.1    de Roock, W.2    Biesmans, B.3    de Schutter, J.4    Piessevaux, H.5    Humblet, Y.6
  • 73
    • 0033573921 scopus 로고    scopus 로고
    • Mechanism of biological synergy between cellular SRC and epidermal growth factor receptor
    • Tice, D.A., Biscardi, J.S., Nickles, A.L. and Parsons, S.J. ( 1999) Mechanism of biological synergy between cellular SRC and epidermal growth factor receptor. Proc Natl Acad Sci U S A 96: 1415-1420.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 1415-1420
    • Tice, D.A.1    Biscardi, J.S.2    Nickles, A.L.3    Parsons, S.J.4
  • 75
  • 76
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • van Cutsem, E., Kohne, C.H., Hitre, E., Zaluski, J., Chang Chien, C.R., Makhson, A. et al. (2009) Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360: 1408-1417.
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3    Zaluski, J.4    Chang Chien, C.R.5    Makhson, A.6
  • 77
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • van Cutsem, E., Peeters, M., Siena, S., Humblet, Y., Hendlisz, A., Neyns, B. et al. (2007) Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 25: 1658-1664.
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4    Hendlisz, A.5    Neyns, B.6
  • 78
    • 28644447595 scopus 로고    scopus 로고
    • Comparison of the novel quantitative arms assay and an enriched PCR-ASO assay for K-RAS mutations with conventional cytology on endobiliary brush cytology from 312 consecutive extrahepatic biliary stenoses
    • van Heek, N.T., Clayton, S.J., Sturm, P.D., Walker, J., Gouma, D.J., Noorduyn, L.A. et al. (2005) Comparison of the novel quantitative arms assay and an enriched PCR-ASO assay for K-RAS mutations with conventional cytology on endobiliary brush cytology from 312 consecutive extrahepatic biliary stenoses. J Clin Pathol 58: 1315-1320.
    • (2005) J Clin Pathol , vol.58 , pp. 1315-1320
    • van Heek, N.T.1    Clayton, S.J.2    Sturm, P.D.3    Walker, J.4    Gouma, D.J.5    Noorduyn, L.A.6
  • 79
    • 59849115730 scopus 로고    scopus 로고
    • (2009) KRAS mutation testing for predicting response to Anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program
    • van Krieken, J.H., Jung, A., Kirchner, T., Carneiro, F., Seruca, R., Bosman, F.T. et al. (2009) KRAS mutation testing for predicting response to Anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program. Virchows Arch 454: 233-235.
    • Virchows Arch , vol.454 , pp. 233-235
    • van Krieken, J.H.1    Jung, A.2    Kirchner, T.3    Carneiro, F.4    Seruca, R.5    Bosman, F.T.6
  • 81
    • 0035394833 scopus 로고    scopus 로고
    • Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis
    • Viloria-Petit, A., Crombet, T., Jothy, S., Hicklin, D., Bohlen, P., Schlaeppi, J.M. et al. (2001) Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res 61: 5090-5101.
    • (2001) Cancer Res , vol.61 , pp. 5090-5101
    • Viloria-Petit, A.1    Crombet, T.2    Jothy, S.3    Hicklin, D.4    Bohlen, P.5    Schlaeppi, J.M.6
  • 82
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan, P.T., Garnett, M.J., Roe, S.M., Lee, S., Niculescu-Duvaz, D., Good, V.M. et al. (2004) Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116: 855-867.
    • (2004) Cell , vol.116 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3    Lee, S.4    Niculescu-Duvaz, D.5    Good, V.M.6
  • 83
    • 24944525406 scopus 로고    scopus 로고
    • Determination of Tp 53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients
    • Westra, J.L., Schaapveld, M., Hollema, H., de Boer, J.P., Kraak, M.M., de Jong, D. et al. (2005) Determination of Tp 53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. J Clin Oncol 23: 5635-5643.
    • (2005) J Clin Oncol , vol.23 , pp. 5635-5643
    • Westra, J.L.1    Schaapveld, M.2    Hollema, H.3    de Boer, J.P.4    Kraak, M.M.5    de Jong, D.6
  • 85
    • 66149083997 scopus 로고    scopus 로고
    • (2009) Epidermal growth factor receptor cooperates with SRC family kinases in acquired resistance to cetuximab
    • Wheeler, D.L., Iida, M., Kruser, T.J., Nechrebecki, M.M., Dunn, E.F., Armstrong, E.A. et al. (2009) Epidermal growth factor receptor cooperates with SRC family kinases in acquired resistance to cetuximab. Cancer Biol Ther 8: 696-703.
    • Cancer Biol Ther , vol.8 , pp. 696-703
    • Wheeler, D.L.1    Iida, M.2    Kruser, T.J.3    Nechrebecki, M.M.4    Dunn, E.F.5    Armstrong, E.A.6
  • 86
    • 34447121976 scopus 로고    scopus 로고
    • EGFR activation results in enhanced cyclooxygenase-2 expression through P 38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas
    • Xu, K. and Shu, H.K. ( 2007) EGFR activation results in enhanced cyclooxygenase-2 expression through P 38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. Cancer Res 67: 6121-6129.
    • (2007) Cancer Res , vol.67 , pp. 6121-6129
    • Xu, K.1    Shu, H.K.2
  • 87
    • 34548509226 scopus 로고    scopus 로고
    • Fcgr2a and Fcgr3a polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab
    • Zhang, W., Gordon, M., Schultheis, A.M., Yang, D.Y., Nagashima, F., Azuma, M. et al. (2007) Fcgr2a and Fcgr3a polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol 25: 3712-3718.
    • (2007) J Clin Oncol , vol.25 , pp. 3712-3718
    • Zhang, W.1    Gordon, M.2    Schultheis, A.M.3    Yang, D.Y.4    Nagashima, F.5    Azuma, M.6
  • 88
    • 0036968713 scopus 로고    scopus 로고
    • PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers
    • Zhou, X.P., Loukola, A., Salovaara, R., Nystrom-Lahti, M., Peltomaki, P., De La Chapelle, A. et al. (2002) PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. Am J Pathol 161: 439-447.
    • (2002) Am J Pathol , vol.161 , pp. 439-447
    • Zhou, X.P.1    Loukola, A.2    Salovaara, R.3    Nystrom-Lahti, M.4    Peltomaki, P.5    De, L.a.6    Chapelle, A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.