Effects of clusterin over-expression on metastatic progression and therapy in breast cancer

BMC Cancer

Volumn 10, Issue , 2010, Pages

  Flanagan, Louise ^a   Whyte, Lorna ^a   Chatterjee, Namita ^a   Tenniswood, Martin ^a,b  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b UNIVERSITY AT ALBANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLUSTERIN; ESTROGEN RECEPTOR ALPHA; PROTEIN BAX; PROTEIN P21; TAMOXIFEN; TUMOR NECROSIS FACTOR ALPHA; CLU PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE; CELL DEATH; CELL GROWTH; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENETIC ENGINEERING; GROWTH RATE; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG METASTASIS; LYMPH NODE METASTASIS; METASTASIS; MOUSE; NONHUMAN; PRIMARY TUMOR; PROTEIN CLEAVAGE; PROTEIN INDUCTION; PROTEIN LOCALIZATION; TUMOR GROWTH; TUMOR VOLUME; ANIMAL; BIOSYNTHESIS; BREAST TUMOR; DISEASE COURSE; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; GENETIC TRANSFECTION; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CLUSTERIN; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MICE; MICE, NUDE; NEOPLASM METASTASIS; TAMOXIFEN; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77953364995     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-10-107     Document Type: Article

References (46)

1. Gu B, España L, Méndez O, Torregrosa A, Sierra A. Organ-selective chemoresistance in metastasis from human breast cancer cells: inhibition of apoptosis, genetic variability and microenvironment at the metastatic focus. Carcinogenesis 2004, 12:2293-2301.
2. Pearse RN. New strategies for the treatment of metastatic bone disease. Clin Breast Cancer 2007, 8:S35-S45. 10.3816/CBC.2007.s.010, 18282368.
3. Shah GD, Abrey LE. Chemotherapy for brain metastases: breast, gynecologic and non-melanoma skin malignancies. Cancer Treat Res 2007, 136:185-197. full_text, 18078271.
4. Kapron JT, Hilliard GM, Lakins JN, Tenniswood MP, West KA, Carr SA, Crabb JW. Identification and characterization of glycosylation sites in human serum clusterin. Protein Sci 1997, 6:2120-2133. 10.1002/pro.5560061007, 2143570, 9336835.
5. Bailey RW, Dunker AK, Brown CJ, Garner EC, Griswold MD. Clusterin, a binding protein with a molten globule-like region. Biochem 2001, 40:11828-11840.
6. Lakins J, Bennett SA, Chen JH, Arnold JM, Morrissey C, Wong P, O'Sullivan J, Tenniswood M. Clusterin biogenesis is altered during apoptosis in the regressing rat ventral prostate. J Biol Chem 1998, 273:27887-27895. 10.1074/jbc.273.43.27887, 9774400.
7. Guenette RS, Corbeil HB, Léger J, Wong K, Mézl V, Mooibroek M, Tenniswood M. Induction of gene expression during involution of the lactating mammary gland of the rat. J Mol Endocrinol 1994, 12:47-60. 10.1677/jme.0.0120047, 8185814.
8. Jenne DE, Tschopp J. Clusterin: the intriguing guises of a widely expressed glycoprotein. Trends Biochem Sci 1992, 17:154-159. 10.1016/0968-0004(92)90325-4, 1585460.
9. Tenniswood MP, Guenette RS, Lakins J, Mooibroek M, Wong P, Welsh JE. Active cell death in hormone-dependent tissues. Cancer Met Rev 1992, 11:197-220.
10. Wilson MR, Easterbrook-Smith SB. Clusterin is a secreted mammalian chaperone. Trends Biochem Sci 2000, 25:95-98. 10.1016/S0968-0004(99)01534-0, 10694874.
11. Shannan B, Seifert M, Leskov K, Willis J, Boothman D, Tilgen W, Reichrath J. Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer. Cell Death Diff 2006, 13:12-19.
12. O'Sullivan J, Whyte L, Drake J, Tenniswood M. Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis. Cell Death Diff 2003, 10:914-927.
13. Yang CR, Leskov K, Hosley-Eberlein K, Criswell T, Pink JJ, Kinsella TJ, Boothman D. Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death. Proc Natl Acad Sci USA 2000, 97:5907-5912. 10.1073/pnas.97.11.5907, 18532, 10823943.
14. Caccamo AE, Desenzani S, Belloni L, Borghetti AF, Bettuzzi S. Nuclear clusterin accumulation during heat shock response: implications for cell survival and thermo-tolerance induction in immortalized and prostate cancer cells. J Cell Physiol 2006, 207:208-219. 10.1002/jcp.20561, 16331665.
15. Michel D, Chatelain G, North S, Brun G. Stress-induced transcription of the clusterin/apoJ gene. Biochem J 1997, 328:45-50. 1218885, 9359832.
16. Carver JA, Rekas A, Thorn DC, Wilson MR. Small heat-shock proteins and clusterin: intra- and extracellular molecular chaperones with a common mechanism of action and function?. IUBMB Life 2003, 55:661-668. 10.1080/15216540310001640498, 14769002.
17. Trougakos IP, Gonos ES. Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Rad Res 2006, 40:1324-1334.
18. Leskov KS, Criswell T, Antonio S, Li J, Yang CR, Kinsella TJ, Boothman DA. When X-ray-inducible proteins meet DNA double strand break repair. Sem Rad Oncol 2001, 11:352-72.
19. Stewart EM, Aquilina JA, Easterbrook-Smith SB, Murphy-Durland D, Jacobsen C, Moestrup S, Wilson MR. Effects of glycosylation on the structure and function of the extracellular chaperone clusterin. Biochem 2007, 46:1412-1422.
20. Lakins JN, Poon S, Easterbrook-Smith SB, Carver JA, Tenniswood MP, Wilson MR. Evidence that clusterin has discrete chaperone and ligand binding sites. Biochem 2002, 41:282-291.
21. de Silva HV, Stuart WD, Park YB, Mao SJ, Gil CM, Wetterau JR, Busch SJ, Harmony JA. Purification and characterization of apolipoprotein J. J Biol Chem 1990, 265:14292-14297.
22. Sensibar JA, Sutkowski DM, Raffo A, Buttyan R, Griswold MD, Sylvester SR, Kozlowski JM, Lee C. Prevention of cell death induced by tumor necrosis factor alpha in LNCaP cells by overexpression of sulfated glycoprotein-2 (clusterin). Cancer Res 1995, 55:2431-2437.
23. Humphreys D, Hochgrebe TT, Easterbrook-Smith SB, Tenniswood MP, Wilson MR. Effects of clusterin overexpression on TNFalpha- and TGFbeta-mediated death of L929 cells. Biochem 1997, 36:15233-15243.
24. Sintich SM, Steinberg J, Kozlowski JM, Lee C, Pruden S, Sayeed S, Sensibar JA. Cytotoxic sensitivity to tumor necrosis factor-alpha in PC3 and LNCaP prostatic cancer cells is regulated by extracellular levels of SGP-2 (clusterin). Prostate 1999, 39:87-93. 10.1002/(SICI)1097-0045(19990501)39:2<87::AID-PROS2>3.0.CO;2-Z, 10221563.
25. Zhan P, Lee EC, Packman K, Tenniswood M. Induction of invasive phenotype by Casodex in hormone-sensitive prostate cancer cells. J Steroid Biochem Mol Biol 2002, 83:101-111. 10.1016/S0960-0760(02)00275-3, 12650706.
26. Lee EC, Zhan P, Schallhorn R, Packman K, Tenniswood M. Antiandrogen-induced cell death in LNCaP human prostate cancer cells. Cell Death Diff 2003, 10:761-71.
27. Steinberg J, Oyasu R, Lang S, Sintich S, Rademaker A, Lee C, Kozlowski JM, Sensibar JA. Intracellular levels of SGP-2 (Clusterin) correlate with tumor grade in prostate cancer. Clin Cancer Res 1997, 10:1707-1711.
28. Pins MR, Fiadjoe JE, Korley F, Wong M, Rademaker AW, Jovanovic B, Yoo TK, Kozlowski JM, Raji A, Yang XJ, Lee C. Clusterin as a possible predictor for biochemical recurrence of prostate cancer following radical prostatectomy with intermediate Gleason scores: a preliminary report. Prostate Cancer Prostatic Dis 2004, 7:243-248. 10.1038/sj.pcan.4500722, 1400553, 15343364.
29. Miyake H, Muramaki M, Kurahashi T, Yamanaka K, Hara I, Gleave M, Fujisawa M. Expression of clusterin in prostate cancer correlates with Gleason score but not with prognosis in patients undergoing radical prostatectomy without neoadjuvant hormonal therapy. Urol 2006, 68:609-614. 10.1016/j.urology.2006.03.017, 16979705.
30. Miyake H, Hara I, Gleave ME. Antisense oligodeoxynucleotide therapy targeting clusterin gene for prostate cancer: Vancouver experience from discovery to clinic. Int J Urol 2005, 12:785-794. 10.1111/j.1442-2042.2005.01173.x, 16201973.
31. Bettuzi S, Davalli P, Astancolle S, Carani C, Madeo B, Tampiera A, Corti A. Tumor progression is accompanied by significant changes in the levels of polyamine metabolism regulatory genes and clusterin (sulfated glycoprotein 2) in human prostate cancer specimens. Cancer Res 2000, 60:28-34.
32. Doustjalali, Yusof R, Yip C-H, Looi L-M, Pillay B, Hashim O. Aberrant expression of acute phase reactant proteins in sera and breast lesions of patients with malignant and benign tumors. Electrophoresis 2004, 25:2392-2401. 10.1002/elps.200305950, 15274022.
33. Redondo M, Villar E, Torres-Muñoz J, Tellez T, Morell M, Petito CK. Overexpression of clusterin in human breast carcinoma. Am J Pathol 2000, 157:393-399. 1850123, 10934144.
34. Wong P, Taillefer D, Lakins J, Pineault J, Chader G, Tenniswood M. Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration. Eur J Biochem 1994, 221:917-925. 10.1111/j.1432-1033.1994.tb18807.x, 8181474.
35. Leskov KS, Klokov DY, Li J, Kinsella TJ, Boothman DA. Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem 2003, 278:11590-11600. 10.1074/jbc.M209233200, 12551933.
36. Yan A, Lennarz WJ. Unraveling the mechanism of protein N-Glycosylation. J Biol Chem 2004, 280:3121-3124. 10.1074/jbc.R400036200, 15590627.
37. Kelleher D, Gilmore R. An evolving view of eukaryotic oligosaccharyl-transferase. Glycobiol 2006, 16:47R-62R.
38. Pahl HL. transduction from the endoplasmic reticulum to the cell nucleus. Physiol Rev 1999, 79:683-701.
39. Sugimoto A, Hozak RR, Nakashima T, Nishimoto T, Rothman JH. Dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates. EMBO J 1995, 14:4434-4441. 394535, 7556086.
40. Hong NA, Flannery M, Hsieh SN, Cado D, Pedersen R, Winoto A. Mice lacking Dad1, the defender against apoptotic death-1, express abnormal N-linked glycoproteins and undergo increased embryonic apoptosis. Dev Biol 2000, 220:76-84. 10.1006/dbio.2000.9615, 10720432.
41. Kelleher D, Gilmore R. DAD1, the defender against apoptotic death, is a subunit of the mammalian oligosaccharyltransferase. Proc Natl Acad Sci USA 1997, 94:4994-4999. 10.1073/pnas.94.10.4994, 24619, 9144178.
42. Nizard P, Tetley S, LeDréan Y, Watrin T, Le Goff P, Wilson MR, Michel D. Stress-Induced retrotranslocation of clusterin/ApoJ into the cytosol. Traffic 2007, 8:554-564. 10.1111/j.1600-0854.2007.00549.x, 17451556.
43. Zhang H, Kim JK, Edwards CA, Xu Z, Taichman R, Wang CY. Clusterin inhibits apoptosis by interacting with activated Bax. Nature Cell Biol 2005, 7:909-915. 10.1038/ncb1291, 16113678.
44. Tuszynski GP, Wang TN, Berger D. Adhesive proteins and the hematogenous spread of cancer. Acta Haematol 1997, 97:29-39. 10.1159/000203657, 8980608.
45. Chambers AF, Naumov GN, Varghese HJ, Nadkarni KV, MacDonald IC, Groom AC. Critical steps in hematogenous metastasis: an overview. Surg Oncol Clin North Am 2001, 10:243-55.
46. Blaschuk O, Burdzy K, Fritz IB. Purification and characterization of a cell-aggregating factor (clusterin), the major glycoprotein in ram rete testis fluid. J Biol Chem 1983, 258:7714-7720.