Mice lacking Dad1, the defender against apoptotic death-1, express abnormal N-linked glycoproteins and undergo increased embryonic apoptosis

Developmental Biology

Volumn 220, Issue 1, 2000, Pages 76-84

  Hong, N A ^a   Flannery, M ^b   Hsieh, S N ^a   Cado, D ^a   Pedersen, R ^b   Winoto, A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Dad1; Glycosylation; Knockout; Reichert's membrane; Visceral endoderm

Indexed keywords

GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN BHK; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMBRYO AXIS; EMBRYO DEATH; GENE MUTATION; HOMOZYGOSITY; MESODERM; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE;

ANIMALIA; CRICETINAE; EUKARYOTA; MAMMALIA; RODENTIA; SACCHAROMYCES CEREVISIAE;

EID: 0034177146     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.9615     Document Type: Article

References (27)

1. Campbell R. M., Metzler M., Granovsky M., Dennis J. W., Marth J. D. Complex asparagine-linked oligosaccharides in Mgat1-null embryos. Glycobiology. 5:1995;535-543.
2. Chen H., Egan J. O., Chiu J. F. Regulation and activities of alpha-fetoprotein. Crit. Rev. Eukaryotic Gene Expression. 7:1997;11-41.
3. Chen W. S., Manova K., Weinstein D. C., Duncan S. A., Plump A. S., Prezioso V. R., Bachvarova R. F., Darnell J. E. Jr. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 8:1994;2466-2477.
4. Coucouvanis E., Martin G. R. Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo. Cell. 83:1995;279-287.
5. Dean J. W. D., Chandrasekaran S., Tanzer M. L. A biological role of the carbohydrate moieties of laminin. J. Biol. Chem. 265:1990;12553-12562.
6. Dragatsis I., Efstratiadis A., Zeitlin A. Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues. Development. 125:1998;1529-1539.
7. -/- embryos. Development. 124:1997;279-287.
8. Guillemot F., Nagy A., Auerbach A., Rossant J., Joyner A. L. Essential role of Mash-2 in extraembryonic development. Nature. 371:1994;333-336.
9. Hakem R., de la Pompa J. L., Sirard C., Mo R., Woo M., Hakem A., Wakeham A., Potter J., Reitmair A., Billia F., Firpo E., Hui C. C., Roberts J., Rossant J., Mak T. W. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 85:1996;1009-1023.
10. Hakomori S. Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. Cancer Res. 56:1996;5309-5318.
11. Harbers K., Mueller U., Grams A., Li E., Jaenisch R., Franz T. Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Proc. Natl. Acad. Sci. USA. 93:1996;12412-12417.
12. Hong N. A., Cado D., Mitchell J., Ortiz B. D., Hsieh S. N., Winoto A. A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1. Mol. Cell. Biol. 17:1997;2151-2157.
13. Hong N. A., Kabra N. H., Hsieh S. N., Cado D., Winoto A. In vivo overexpression of Dad1, the defender against apoptotic death-1, enhances T cell proliferation but does not protect against apoptosis. J. Immunol. 163:1999;1888-1893.
14. Ioffe E., Stanley P. Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates. Proc. Natl. Acad. Sci. USA. 91:1994;728-732.
15. Kelleher D. J., Gilmore R. DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase. Proc. Natl. Acad. Sci. USA. 94:1997;4994-4999.
16. Koutsourakis M., Langeveld A., Patient R., Beddington R., Grosveld F. The transcription factor GATA6 is essential for early extraembryonic development. Development. 126:1999;723-732.
17. Leivo I., Vaheri A., Timpl R., Wartiovaara J. Appearance and distribution of collagens and laminin in the early mouse embryo. Dev. Biol. 76:1980;100-114.
18. Makishima T., Nakashima T., Nagata-Kuno K., Fukushima K., Iida H., Sakaguchi M., Ikehara Y., Komiyama S., Nishimoto T. The highly conserved DAD1 protein involved in apoptosis is required for N-linked glycosylation. Genes Cells. 2:1997;129-141.
19. Metzler M., Gertz A., Sarkar M., Schachter H., Schrader J. W., Marth J. D. Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development. EMBO J. 13:1994;2056-2065.
20. Morrisey E., Tang Z., Sigrist K., Lu M., Jiang F., Ip H., Parmacek M. GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev. 12:1998;3579-3590.
21. Muramatsu T. Cell surface glycoproteins: Biochemical, immunological and molecular biological studies. Nagoya J. Med. Sci. 57:1994;95-108.
22. Nakashima T., Sekiguchi T., Kuraoka A., Fukushima K., Shibata Y., Komiyama S., Nishimoto T. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. Mol. Cell. Biol. 13:1993;6367-6374.
23. Patapoutian A., Yoon J. K., Miner J. H., Wang S., Stark K., Wold B. Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome. Development. 121:1995;3347-3358.
24. Porter J. A., Young K. E., Beachy P. A. Cholesterol modification of hedgehog signaling proteins in animal development. Science. 274:1996;255-259.
25. Silberstein S., Collins P. G., Kelleher D. J., Gilmore R. The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms. J. Cell Biol. 131:1995;371-383.
26. Surani M. A. Glycoprotein synthesis and inhibition of glycosylation by tunicamycin in preimplantation mouse embryos: Compaction and trophoblast adhesion. Cell. 18:1979;217-227.
27. Zeitlin S., Liu J. P., Chapman D. L., Papaioannou V. E., Efstratiadis A. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat. Genet. 11:1995;155-163.