Analysis of VH gene rearrangement and somatic hypermutation in Sjogren's syndrome and IgG4-related sclerosing sialadenitis

Scandinavian Journal of Immunology

Volumn 72, Issue 1, 2010, Pages 44-49

  Sakuma, H ^a,b   Okumura, F ^a   Miyabe, S ^a,b   Sugiura, M ^c   Joh, T ^a   Shimozato, K ^b   Inagaki, H ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c Nagoya City University West Medical Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN G4 RELATED SCLEROSING SIALOADENITIS; IMMUNOHISTOCHEMISTRY; MALE; PATHOGENESIS; PRIORITY JOURNAL; SIALOADENITIS; SIALOLITHIASIS; SJOEGREN SYNDROME; SOMATIC HYPERMUTATION; VH GENE;

AGED; BIOPSY; CLONING, MOLECULAR; DNA; FEMALE; GENE REARRANGEMENT; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; SIALADENITIS; SJOGREN'S SYNDROME; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 77953332907     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2010.02405.x     Document Type: Article

References (28)

1. Küttner H. Über entzündliche tumoren der submaxillar-speicheldrüse. Bruns'Beitr Klin Chir 1896 15 : 815 828.
2. Chan JK. Kuttner tumor (chronic sclerosing sialadenitis) of the submandibular gland: an underrecognized entity. Adv Anat Pathol 1998 5 : 239 251.
3. Yamamoto M, Harada S, Ohara M et al. Clinical and pathological differences between Mikulicz's disease and Sjogren's syndrome. Rheumatology (Oxford) 2005 44 : 227 234. (Pubitemid 40277409)
4. Kitagawa S, Zen Y, Harada K et al. Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis. Am J Surg Pathol 2005 29 : 783 791.
5. Hamano H, Kawa S, Horiuchi A et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med 2001 344 : 732 738.
6. Nakazawa T, Ohara H, Sano H et al. Clinical differences between primary sclerosing cholangitis and sclerosing cholangitis with autoimmune pancreatitis. Pancreas 2005 30 : 20 5.
7. Kamisawa T, Okamoto A. IgG4-related sclerosing disease. World J Gastroenterol 2008 14 : 3948 3955.
8. Daniels TE, Whitcher JP. Association of patterns of labial salivary gland inflammation with keratoconjunctivitis sicca. Analysis of 618 patients with suspected Sjögren's syndrome. Arthritis Rheum 1994 37 : 869 877.
9. Fujibayashi T, Sugai S, Miyasaka N, Hayashi Y, Tsubota K. Revised Japanese criteria for Sjögren's syndrome (1999): availability and validity. Mod Rheumatol 1999 14 : 425 434.
10. Agematsu K. Memory B cells and CD27. Histol Histopathol 2000 15 : 573 576.
11. Steiniger B, Timphus EM, Jacob R, Barth PJ. CD27+ B cells in human lymphatic organs: re-evaluating the splenic marginal zone. Immunology 2005 116 : 429 442.
12. Mason DY, Cordell JL, Brown MH et al. CD79a: a novel marker for B-cell neoplasms in routinely processes tissue samples. Blood 1995 86 : 1453 1459.
13. Inagaki H, Chan JK, Ng JW et al. Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features. Am J Pathol 2002 160 : 1435 1443.
14. Yoshida M, Okabe M, Eimoto T et al. Immunoglobulin VH genes in thymic MALT lymphoma are biased toward a restricted repertoire and are frequently unmutated. J Pathol 2006 208 : 415 422.
15. Sakuma H, Nakamura T, Uemura N et al. Immunoglobulin VH gene analysis in gastric MALT lymphomas. Mod Pathol 2007 20 : 460 466.
16. Lossos IS, Okada CY, Tibshirani R et al. Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomas. Blood 2000 95 : 1797 1803.
17. Elagib KE, Borretzen M, Johsson R et al. Rheumatoid factors in primary Sjogren's syndrome (pSS) use diverse VH region genes, the majority of which show no evidence of somatic hypermutation. Clin Exp Immunol 1999 117 : 388 394.
18. Hansen A, Jacobi A, Pruss A et al. Comparison of immunoglobulin heavy chain rearrangements between peripheral and glandular B cells in a patient with primary Sjögren's Syndrome. Scand J Immunol 2003 57 : 470 479.
19. Brezinschek HP, Brezinschek RI, Lipsky PE. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 1995 155 : 190 202.
20. Behrendt M, Partrige LJ, Griffiths B, Goodfield M, Snaith M, Lindsey NJ. The role of somatic mutation in determining the affinity of anti-DNA antibodies. Clin Exp Immunol 2003 131 : 182 189.
21. Van Esch WJ, Reparon-Schuijt CC, Hamstra HJ et al. Human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selection. Clin Exp Immunol 2003 131 : 364 376.
22. Dörner T, Lipsky PE. Molecular basis of immunoglobulin variable region gene usage in systemic autoimmunity. Clin Exp Med 2005 4 : 159 169.
23. Denomme GA, Mahmoudi M, Cairns E, Bell DA. Immunoglobulin V region sequences of two human antiplatelet monoclonal autoantibodies derived from B cells of normal origin. J Autoimmun 1994 7 : 521 535. (Pubitemid 24268390)
24. Børretzen M, Chapman C, Natvig JB, Thompson KM. Differences in mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germ-line gene usage. Eur J Immunol 1997 27 : 735 741.
25. Li Z, Schettino EW, Padlan EA, Ikematsu H, Casali P. Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double-and single-stranded DNA. Eur J Immunol 2000 30 : 2015 2026.
26. Stott DI, Hiepe F, Hummel M et al. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome. J Clin Invest 1998 102 : 938 946.
27. Elagib KE, Borretzen M, Vatn I, Natvig JB, Thompson KM. Characterization and V(H) sequences of human monoclonal anti-F(ab')(2) autoantibodies from normal and Sjogren's syndrome patients. Clin Immunol 2001 98 : 62 9.
28. Miklos JA, Swerdlow SH, Bahler DW. Salivary gland mucosa-associated lymphoid tissue lymphoma immunoglobulin V(H) genes show frequent use of V1-69 with distinctive CDR3 features. Blood 2000 95 : 3878 3884.