Rheumatoid factors in primary Sjogren's syndrome (pSS) use diverse V(H) region genes, the majority of which show no evidence of somatic hypermutation

Clinical and Experimental Immunology

Volumn 117, Issue 2, 1999, Pages 388-394

  Elagib, Kamal Eldin Elsheikh ^a,c,d   Borretzen M ^a   Jonsson, R ^b   Haga, H J ^b   Thoen, J ^a   Thompson, K M ^a   Natvig, J B ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF GEZIRA   (Sudan)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Heavy chain variable region gene; Rheumatoid factor; Sjogren's syndrome

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; RHEUMATOID FACTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE REARRANGEMENT; GENE STRUCTURE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MALE; MOLECULAR CLONING; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME;

ADULT; AGED; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CELL LINE, TRANSFORMED; CLONING, MOLECULAR; DNA MUTATIONAL ANALYSIS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; RHEUMATOID FACTOR; SJOGREN'S SYNDROME;

EID: 0032817313     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00963.x     Document Type: Article

References (51)

1. 1 Tzioufas AG, Talal N, Moutsopoulos HM. Sjögren's syndrome: from polyclonal B cell activation to monoclonal B cell proliferation. In: Panayi GS, Whaley K, eds. Immunology of connective tissue diseases. Dordrecht: Kluwer Academic, 1994:335-54.
2. 2 Lane HC, Fauci AS. Sjögren's syndrome. In: Wilson JD, Braunwald E, Isselbacher KJ et al., eds. Harrison's principles of internal medicine. New York: McGraw-Hill, 1991:1449-50.
3. 3 Tzioufas AG, Moutsopoulos HM. Sjögren's syndrome. In: Klippel JH, Dieppe PA, eds. Rheumatology. London: Mosby, 1998:7.32.1-12.
4. 4 Børretzen M, Mellbye OJ, Thompson KM, Natvig JB. Rheumatoid factors. In: Peter JB, Shoenfeld Y, eds. Autoantibodies. Amsterdam: Elsiver Science B. V., 1996:706-15.
5. 5 Markusse HM, Otten HG, Vroom TM, Smeets TJ, Fokkens N, Breedveld FC. Rheumatoid factor isotypes in serum and salivary fluid of patients with primary Sjögren's syndrome. Clin Immunol Immunopathol 1993; 66:26-32.
6. 6 Atkinson JC, Fox PC, Travis WD et al. IgA rheumatoid factor and IgA containing immune complexes in primary Sjögren's syndrome. J Rheumatol 1989; 16:1205-10.
7. 7 Zvaifler NJ. The immunopathology of joint inflammation in rheumatoid arthritis. Adv Immunol 1973; 16:265-336.
8. 8 Fehr K, Zelvart M, Rauber M, Knopef M, Baici A, Salagam P, Boni A. Production of agglutinators and rheumatoid factors in plasma cells of rheumatoid and non-rheumatoid synovial tissues. Arthritis Rheum 1981; 24:510-9.
9. 9 Kalsi J, Isenberg D. Rheumatoid factor: primary or secondary event in the pathogenesis of RA? Int Arch Allergy Immunol 1993; 102:209-15.
10. 10 Heyman B. Fe-dependent IgG mediated suppression of the antibody response: fact or artefact? Scand J Immunol 1990; 31:601-7.
11. 11 Posnett DN, Edinger J. When do microbes stimulate rheumatoid factor? J Exp Med 1997; 185:1721-3.
12. 12 Børrezten M, Natvig JB, Thompson KM. Hetrogenous RF structures between and within healthy individuals are not related to HLA-DRB1 *0401. Mol Immmunol 1997; 34:929-38.
13. 13 Djavad N, Bas S, Shi X, Schwager J, Jeannet M, Vischer T, Roosnek E. Comparison of rheumatoid factors of rheumatoid arthritis patients, of individual with mycobacterial infections and of normal controls: evidence for maturation in the absence of an autoimmune response. Eur J Immunol 1996; 26:2480-6.
14. 14 Thompson KM, Randen I, Børretzen M, Førre Ø, Natvig JB. Variable region gene usage of human monoclonal rheumatoid factors derived from healthy donors following immunization. Eur J Immunol 1994; 24:1771-8.
15. 15 Randen I, Brown D, Thompson KM et al. Clonally related IgM rheumatoid factors undergo affinity maturation in the synovial tissue. J Immunol 1992; 148:3296-301.
16. 16 Randen I, Thompson KM, Thorpe S, Førre Ø, Natvig JB. Human monoclonal IgG rheumatoid factors from the synovial tissue of patients with rheumatoid arthritis. Scand J Immunol 1993; 37:668-72.
17. 17 Randen I, Thompson KM, Natvig JB, Førre Ø, Waalen K. Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue: production and characterization. Clin Exp Immunol 1989; 78:13-18.
18. 18 Børretzen M, Randen I, Zdarsky E, Førre Ø, Natvig JB, Thompson KM. Control of antibody affinity by selection against amino acid replacements in the complementary determining regions. Proc Natl Acad Sci USA 1994; 91:12917-21.
19. 19 Pascual V, Randen I, Thompson K, Sioud M, Førre Ø, Natvig J, Capra JD. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germline genes. J Clin Invest 1990; 86:1320-8.
20. L gene segments and extensive variability in CDR-3. Scand J Immunol 1992; 36:349-62.
21. 21 Børrezten M, Randen I, Natvig JB, Thompson KM. Structural restriction in the heavy chain CDR3 of human rheumatoid factors. J Immunol 1995; 155:3630-7.
22. 22 Børrezten M, Chapman C, Natvig JB, Thompson KM. Differences in mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germline gene usage. Eur J Immunol 1997; 27:735-41.
23. 23 Ermel RW, Kenny TP, Wong A, Chen PP, Malyj W, Robbins DL. Analysis of the molecular basis of synovial rheumatoid factors in rheumatoid arthritis. Clin Immunol Immunopathol 1997; 84:307-17.
24. H and V kappa subgroups. Eur J Immunol 1990; 20:863-8.
25. 25 Jain RI, Fais F, Kaplan S et al. Ig H and L chain variable region gene sequence analysis of twelve synovial tissue-derived B cell lines producing IgA, IgG, and IgM rheumatoid factors structure/function comparisons of antigenic specificity, V gene sequence, and IG isotype. Autoimmunity 1995; 22:229-43.
26. KII gene segments. Arthritis Rheum 1992; 35:900-4.
27. 27 Vitali C, Bombardieri S, Moutsopoulos HM et al. Preliminary criteria for the classification of Sjögren's syndrome. Results of an EEC prospective concerted action. Arthritis Rheum 1993; 36:340-7.
28. 28 Kjeldsen-Kragh J, Mellbye OJ, Haugen M, Mollnes TE, Hammer HB, Sioud M, Førre Ø. Changes in laboratory variables in rheumatoid arthritis patients during a trial of fasting and one-year vegetarian diet. Scand J Rheumatol 1995; 24:85-93.
29. 29 Thompson KM, Hough DW, Maddison PJ, Melamed MD, Hughes JN. The efficient production of stable human monoclonal antibody secreting hybridomas from EBV transformed lymphocytes using the mouse myeloma X63-Ag8.653 as fusion partner. J Immunol Methods 1986; 94:7-12.
30. 30 Chomezynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-9.
31. 31 Gaarder PI, Natvig JB. Hidden rheumatoid factors reacting with 'Non a' and other antigens of native autologus IgG. J Immunol 1970; 105: 928-37.
32. 32 Guigou V, Cuisinier AM, Tonnelle C, Moinier D, Fougereau M, Fumoux F. Human immunoglobulin VH and VK repertoire revealed by in situ hybridization. Mol Immunol 1990; 27:935-40.
33. 33 Zouali M, Theze J. Probing VH gene-family utilization in human peripheral B cells by in situ hybridization. J Immunol 1991; 146: 2855-64.
34. HIII-associated cross-reactive idiotypes on human B-lymphocytes: association with staphylococcal protein A (SPA) binding and staphylococcus aureus Cowan I (SAC) stimulation. J Immunol 1991; 146:936-40.
35. 35 Randen I, Thompson KM, Natvig JB et al. Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of antigen driven response. Immunol Rev 1992; 128:49-71.
36. 36 Shokri F, Mageed RA, Kitas GD, Katsikis P, Moutsopoulos HM, Jefferis R. Quantification of cross-reactive idiotype-positive rheumatoid factor produced in autoimmune rheumatic diseases. An indicator of clonality and B cell proliferate mechanisms. Clin Exp Immunol 1991; 85:20-27.
37. 37 Melero J, Aguilera I, Mageed RA, Jefferis R, Tarragó D, Núòez-Roldán A, Sánchez B. The frequent expansion of a subpopulation of B cells that express RF-associated cross reactive idiotypes: evidence from analysis of a panel of autoreactive monoclonal antibodies. Scand J Immunol 1998; 48:152-8.
38. + B cells from a rheumatoid arthritis patient. Int Immunol 1991; 3:1188-99.
39. 39 Youngblood K, Fruchter L, Ding G, Lopez J, Bonagura V, Davidson A. Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated. J Clin Invest 1994: 93:852-61.
40. + B) cells make hypermutated high affinity IgM rheumatoid factors. J Immunol 1993; 151:473-88.
41. 41 Shokri F, Mageed RA, Maziak BR, Talal N, Amos N, William BD, Jefferis R. Lymphoproliferation in primary Sjögren's syndrome - Evidence of selective expansion of a B cell subset characterized by the expression of cross reactive idiotypes. Arthritis Rheum 1993; 36:1128-36.
42. 42 Shokri F, Mageed RA, Kitas GD, Moutsopoulos HM, Jefferis R. The level of rheumatoid factor associated cross-reactive idiotypes in Sjögren's syndrome, rheumatoid arthritis, SLE and healthy individuals (abstract). Br J Rheumatol 1989; 28 (Suppl. 1):40.
43. 43 Shimizu S, Sugai S, Imaoka T, Sawada M, Konda S. Monoclonal anti-idiotypic antibodies against monoclonal rheumatoid factors derived from patients with Sjögren's syndrome. Scand J Rheumatol 1986; Suppl. 61:106-10.
44. 44 Sanz I. Multiple mechanism participate in the generation of diversity of human H chain CDR3 regions. J Immunol 1991; 147:1720-9.
45. 45 Yamada M, Wasserman R, Reichard BA, Shane S, Caton AJ, Rovera G. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J Exp Med 1991; 173:395-407.
46. 46 Fox RI, Chen P, Carson DA, Fong S. Expression of cross-reactive idiotype on rheumatoid factor in patients with Sjögren's syndrome. J Immunol 1986; 136:477-83.
47. 47 Sugai S, Saito I, Masaki Y, Takeshita S, Shimizu S, Tachibana J, Miyasaka N. Rearrangement of the rheumatoid factor related germline gene Vg and bcl-2 expression in lymphoproliferative disorders in patients with Sjögren's syndrome. Clin Immunol Immunopathol 1994; 72:181-6.
48. 48 Deacon EM, Mathews JB, Potts AJ, Hamburger J, Mageed RA. Expression of rheumatoid factor associated cross reactive idiotopes by glandular B cells in Sjögren's syndrome. Clin Exp Immunol 1991; 83:280-5.
49. 49 Stott DI, Hlepe F, Hummel M, Steinhauser G, Berek C. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjögren's syndrome. J Clin Invest 1998; 102:938-46.
50. 50 Bahler DW, Swerdlow SH. Clonal salivary gland infiltrates associated with myoepithelial sialadenitis (Sjögren's syndrome) begin as nonmalignant antigen-selected expansions. Blood 1998; 91:1864-72.
51. 51 Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. Sequences of proteins of immunological interest. Bethesda: NIH Publication, 1991: no. 91-3243.