Diallyl disulfide induces caspase-dependent apoptosis via mitochondria-mediated intrinsic pathway in B16F-10 melanoma cells by up-regulating P53, caspase-3 and down-regulating pro-inflammatory cytokines and nuclear factor- κβ-mediated Bcl-2 activation

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 29, Issue 2, 2010, Pages 113-125

  Pratheeshkumar, P ^a   Thejass, P ^a   Kutan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Apoptosis; B16F 10; Diallyl disulfide; NF B; p53; Pro inflamatory cytokines

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; CASPASE; CASPASE 3; CASPASE 9; CYCLIC AMP; CYTOKINE; DIALLYL DISULFIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NUCLEAR FACTOR; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN P50; PROTEIN P53; TRANSCRIPTION FACTOR REL; TUMOR NECROSIS FACTOR ALPHA; ALLYL COMPOUND; ANTINEOPLASTIC AGENT; DISULFIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DNA FRAGMENTATION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION; MELANOMA B16; MELANOMA CELL; METASTASIS; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; ANIMAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MELANOMA, EXPERIMENTAL; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ALLIUM SATIVUM;

ALLYL COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CYTOKINES; DISULFIDES; GENE EXPRESSION REGULATION; GENES, P53; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; MELANOMA, EXPERIMENTAL; MICE; MITOCHONDRIA; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 77953331832     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.v29.i2.50     Document Type: Article

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