Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 12, 2010, Pages 4433-4440

  Lavaggi, María Laura ^a   Cabrera, Mauricio ^a   Aravena, María de los Ángeles ^b   Olea Azar, Claudio ^b   López de Ceráin, Adela ^c   Monge, Antonio ^c   Pachón, Gisela ^d   Cascante, Marta ^d   Bruno, Ana María ^e   Pietrasanta, Lía I ^f   González, Mercedes ^a   Cerecetto, Hugo ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSITY OF NAVARRA   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

^e Facultad de Farmacia y Bioquimica   (Argentina)

^f UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Benzo a phenazine 7,12 dioxides; Bioreductive agents; DNA fragmentation

Indexed keywords

BENZO[A]PHENAZINE 7,12 DIOXIDE; CYTOTOXIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PHENAZINE DERIVATIVE;

AEROBIC METABOLISM; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL SURVIVAL; CLONOGENESIS; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA FRAGMENTATION; DRUG DNA INTERACTION; NONHUMAN; ANIMAL; CACO 2 CELL LINE; CELL HYPOXIA; CELL LINE; CHEMISTRY; COLONIC NEOPLASMS; DRUG EFFECTS; HAMSTER; HUMAN; SYNTHESIS; TOXICITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CACO-2 CELLS; CELL HYPOXIA; CELL LINE; COLONIC NEOPLASMS; CRICETINAE; DNA DAMAGE; DNA FRAGMENTATION; HUMANS; PHENAZINES;

EID: 77953323197     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.074     Document Type: Article

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