Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 4, 2009, Pages 1623-1629

  Urquiola, Carolina ^a   Vieites, Marisol ^a   Torre, María H ^a   Cabrera, Mauricio ^a   Lavaggi, María Laura ^a   Cerecetto, Hugo ^a   González, Mercedes ^a   Cerain, Adela López de ^b   Monge, Antonio ^b   Smircich, Pablo ^c   Garat, Beatriz ^c   Gambino, Dinorah ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSITY OF NAVARRA   (Spain)

^c UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

Anti tumor agents; Hypoxia selective cytotoxins; N,O Ligands; Palladium; Quinoxaline N1,N4 dioxides

Indexed keywords

CYTOTOXIN; MISONIDAZOLE; MITOMYCIN C; PALLADIUM COMPLEX; PLASMID DNA; QUINOXALINE DERIVATIVE; RB 90740; TIRAPAZAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL HYPOXIA; CONDUCTOMETRY; CONTROLLED STUDY; DNA SUPERCOILING; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; INFRARED SPECTROSCOPY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; THERMOGRAVIMETRY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CRICETINAE; CRICETULUS; DNA; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; NITRILES; ORGANOMETALLIC COMPOUNDS; PALLADIUM; PLASMIDS; PRODRUGS; QUINOXALINES; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 60049090570     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.064     Document Type: Article

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