In vitro and in vivo evaluation of polyoxyethylene esters as dermal prodrugs of ketoprofen, naproxen and diclofenac

European Journal of Pharmaceutical Sciences

Volumn 14, Issue 2, 2001, Pages 123-134

  Bonina, Francesco Paolo ^a   Puglia, Carmelo ^a   Barbuzzi, Tony ^a   de Caprariis, Paolo ^b   Palagiano, Francesco ^c   Rimoli, Maria Grazia ^c   Saija, Antonella ^d  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Controlled release; Dermal prodrug; NSAIDs; Polyoxyethylene glycols; Skin permeation

Indexed keywords

DERMAL PRODRUGS;

BIOLOGICAL MEMBRANES; DRUG PRODUCTS; ENZYMES; GLYCOLS; HYDROLYSIS; SKIN;

ESTERS;

BUFFER; DICLOFENAC; DICLOFENAC DERIVATIVE; ESTERASE; KETOPROFEN; KETOPROFEN DERIVATIVE; NAPROXEN; NAPROXEN DERIVATIVE; NICOTINIC ACID METHYL ESTER; NONSTEROID ANTIINFLAMMATORY AGENT; POLYOXYETHYLENE DERIVATIVE; POLYOXYETHYLENE ESTER; PRODRUG; UNCLASSIFIED DRUG; WATER;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG HYDROLYSIS; DRUG SOLUBILITY; DRUG SYNTHESIS; ERYTHEMA; EVALUATION; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIPOPHILICITY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SKIN; SKIN PERMEABILITY; SOLUTION AND SOLUBILITY; VOLUNTEER;

ADMINISTRATION, CUTANEOUS; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; DICLOFENAC; ERYTHEMA; FEMALE; GELS; HUMANS; KETOPROFEN; MALE; MIDDLE AGED; NAPROXEN; POLYETHYLENE GLYCOLS; PRODRUGS; SKIN ABSORPTION; SOLUBILITY; SOLVENTS;

EID: 0034898142     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00163-4     Document Type: Article

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