Synthesis of methoxypoly(ethylene glycol) carbonate prodrugs of zidovudine and penetration through human skin in vitro

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 6, 2009, Pages 721-731

  N'Da, David D ^a   Breytenbach, Jaco C ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

Author keywords

AZT; Methoxypoly(ethylene glycol) (MPEG); Oxyethylene; Prodrug; Transdermal penetration

Indexed keywords

3' AZIDO 3' DEOXYTHYMIDIN 5' YL O METHOXY(ETHYLENE GLYCOL) CARBONATE; 3' AZIDO 3' DEOXYTHYMIDIN 5' YL O METHOXYDI(ETHYLENE GLYCOL) CARBONATE; 3' AZIDO 3' DEOXYTHYMIDIN 5' YL O METHOXYDODECA(ETHYLENE GLYCOL) CARBONATE; 3' AZIDO 3' DEOXYTHYMIDIN 5' YL O METHOXYHEPTADECA(ETHYLENE GLYCOL) CARBONATE; 3' AZIDO 3' DEOXYTHYMIDIN 5' YL O METHOXYOCTA(ETHYLENE GLYCOL) CARBONATE; 3' AZIDO 3' DEOXYTHYMIDIN 5' YL O METHOXYTRI(ETHYLENE GLYCOL) CARBONATE; 4 NITROPHENOL; CARBONIC ACID DERIVATIVE; CHLOROFORMIC ACID ETHYL ESTER; MACROGOL DERIVATIVE; PHOSPHATE BUFFERED SALINE; PRODRUG; UNCLASSIFIED DRUG; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ETHYLENE GLYCOL;

ARTICLE; DRUG ACTIVATION; DRUG CONJUGATION; DRUG DIFFUSION; DRUG HALF LIFE; DRUG PENETRATION; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PH; SKIN PENETRATION; TRANSDERMAL DRUG ADMINISTRATION; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRADERMAL DRUG ADMINISTRATION; MASS SPECTROMETRY; METABOLISM; PERMEABILITY; SKIN; SKIN ABSORPTION; SOLUBILITY; SYNTHESIS;

ADMINISTRATION, CUTANEOUS; ANTI-HIV AGENTS; CARBONATES; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG STABILITY; ETHYLENE GLYCOL; FEMALE; HUMANS; MASS SPECTROMETRY; PERMEABILITY; PRODRUGS; SKIN; SKIN ABSORPTION; SOLUBILITY; ZIDOVUDINE;

EID: 68849129960     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp/61.06.0004     Document Type: Article

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