GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons

BMC Neuroscience

Volumn 11, Issue , 2010, Pages

  Chung, Eun S ^a   Bok, Eugene ^a,b   Sohn, Sunghyang ^b   Lee, Young D ^b   Baik, Hyung H ^a   Jin, Byung K ^a  

^a Kyung Hee University Hospital   (South Korea)

^b Ajou University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; DOPAMINE; GANGLIOSIDE GT 1B; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN KINASE B; SERINE; TAU PROTEIN; THREONINE; GANGLIOSIDE; TRISIALOGANGLIOSIDE GT1;

ARTICLE; CELL DEATH; CELL STRUCTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOWNSTREAM PROCESSING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; FRAGMENTATION REACTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MESENCEPHALON; NERVE CELL CULTURE; NEUROTOXICITY; NICK END LABELING; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; APOPTOSIS; CELL COUNT; CELL CULTURE; CYTOLOGY; DRUG EFFECT; FEMALE; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; PHOSPHORYLATION; RAT; SPRAGUE DAWLEY RAT;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL COUNT; CELLS, CULTURED; DOPAMINE; FEMALE; GANGLIOSIDES; GLYCOGEN SYNTHASE KINASE 3; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MESENCEPHALON; MICROSCOPY, IMMUNOELECTRON; NEURONS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TAU PROTEINS;

EID: 77953319336     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-11-74     Document Type: Article

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