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Volumn 128, Issue 1-3, 2010, Pages 37-45

New ventures in the genotoxic and cytotoxic effects of macrocyclic lactones, Abamectin and Ivermectin

Author keywords

Abamectin; Avermectins; Cytotoxicity; Genotoxicity; Ivermectin

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; ABAMECTIN; ALBENDAZOLE; ANTIPARASITIC AGENT; CELL DNA; CHLORIDE CHANNEL; IVERMECTIN; LACTONE DERIVATIVE; PESTICIDE;

EID: 77953289630     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000293923     Document Type: Review
Times cited : (39)

References (69)
  • 1
    • 0004361466 scopus 로고    scopus 로고
    • Avermectin
    • Wexler P (ed) (Academic Press, San Diego)
    • Agarwal AK: Avermectin, in Wexler P (ed): Encyclopedia of Toxicology, pp 89-90 (Academic Press, San Diego 1998).
    • (1998) Encyclopedia of Toxicology , pp. 89-90
    • Agarwal, A.K.1
  • 2
    • 2142722879 scopus 로고
    • Investigation on sister chromatid exchange (SCE) by Ivermectin
    • Aleksić N, Barjaktarović N: Investigation on sister chromatid exchange (SCE) by Ivermectin. Genetika 25: 219-225 (1993).
    • (1993) Genetika , vol.25 , pp. 219-225
    • Aleksić, N.1    Barjaktarović, N.2
  • 3
    • 2842572915 scopus 로고    scopus 로고
    • Investigation of the genotoxic effects of Ivermectin on human lymphocytes
    • Aleksić N, Milutinović M, Bakrać T: Investigation of the genotoxic effects of Ivermectin on human lymphocytes. Acta Vet Brno 46: 51-55 (1996).
    • (1996) Acta Vet Brno , vol.46 , pp. 51-55
    • Aleksić, N.1    Milutinović, M.2    Bakrać, T.3
  • 5
    • 0028237312 scopus 로고
    • Genotoxic effects of the carbamate insecticide methomyl. I. In vitro studies with pure compound and the technical formulation 'Lannate 25'
    • DOI 10.1002/em.2850230408
    • Bonatti S, Bolognesi C, Degan P, Abbondandolo A: Genotoxic effects of the carbamate insecticide methomyl. I. In vitro studies with pure compound and the technical formulation "Lannate 25". Environ Mol Mutagen 23: 306-311 (1994). (Pubitemid 24227889)
    • (1994) Environmental and Molecular Mutagenesis , vol.23 , Issue.4 , pp. 306-311
    • Bonatti, S.1    Bolognesi, C.2    Degan, P.3    Abbondandolo, A.4
  • 6
    • 15544364090 scopus 로고    scopus 로고
    • Veterinary medicines and the environment
    • Boxall A, Long C: Veterinary medicines and the environment. Environ Toxicol Chem 24: 759-760 (2005).
    • (2005) Environ Toxicol Chem , vol.24 , pp. 759-760
    • Boxall, A.1    Long, C.2
  • 7
  • 8
    • 0002062818 scopus 로고
    • Isolation and characterization of the producing organism
    • Campbell WC (ed) (Springer, New York)
    • Burg RW, Stapley EO: Isolation and characterization of the producing organism, in Campbell WC (ed): Ivermectin and Abamectin, pp 24-32 (Springer, New York 1989).
    • (1989) Ivermectin and Abamectin , pp. 24-32
    • Burg, R.W.1    Stapley, E.O.2
  • 9
    • 0021400788 scopus 로고
    • Ivermectin: A review of efficacy and safety
    • Campbell WC, Benz GW: Ivermectin: a review of efficacy and safety. J Vet Pharmacol Ther 7: 1-16 (1984).
    • (1984) J Vet Pharmacol Ther , vol.7 , pp. 1-16
    • Campbell, W.C.1    Benz, G.W.2
  • 11
    • 0028786988 scopus 로고
    • Temporary variations in chromosomal aberrations in a group of agricultural workers exposed to pesticides
    • Carbonell E, Valbuena A, Xamena N, Creus A, Marcos R: Temporary variations in chromosomal aberrations in a group of agricultural workers exposed to pesticides. Mutat Res 344: 127-134 (1995).
    • (1995) Mutat Res , vol.344 , pp. 127-134
    • Carbonell, E.1    Valbuena, A.2    Xamena, N.3    Creus, A.4    Marcos, R.5
  • 13
    • 35548930208 scopus 로고    scopus 로고
    • Cytogenetic effects of commercial formulations of deltamethrin and/or isoproturon on human peripheral lymphocytes and mouse bone marrow cells
    • Chauhan LK, Kumar M, Paul BN, Goel SK, Gupta SK: Cytogenetic effects of commercial formulations of deltamethrin and/or isoproturon on human peripheral lymphocytes and mouse bone marrow cells. Environ Mol Mutagen 48: 636-648 (2007).
    • (2007) Environ Mol Mutagen , vol.48 , pp. 636-648
    • Chauhan, L.K.1    Kumar, M.2    Paul, B.N.3    Goel, S.K.4    Gupta, S.K.5
  • 14
    • 51449100988 scopus 로고    scopus 로고
    • Genotoxicity induced by pesticide mixtures: In-vitro studies on human peripheral blood lymphocytes
    • Das PP, Shaik AP, Jamil K: Genotoxicity induced by pesticide mixtures: in-vitro studies on human peripheral blood lymphocytes. Toxicol Ind Health 23: 449-458 (2007).
    • (2007) Toxicol Ind Health , vol.23 , pp. 449-458
    • Das, P.P.1    Shaik, A.P.2    Jamil, K.3
  • 21
    • 0001877965 scopus 로고
    • Chemistry
    • Campbell WC (ed) (Springer-Verlag, New York)
    • Fisher MH, Mrozik H: Chemistry, in Campbell WC (ed): Ivermectin and Abamectin, pp 1-23 (Springer-Verlag, New York 1989).
    • (1989) Ivermectin and Abamectin , pp. 1-23
    • Fisher, M.H.1    Mrozik, H.2
  • 24
    • 77953293465 scopus 로고
    • Study No. TT 82-8506, 82-8510, 82-8512, 82-8519. Unpublished report prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA
    • Gordon LR, Bradley MO, Patterson S: V-79 mammalian cell mutagenesis assay with abamectin (MK 0936). Study No. TT 82-8506, 82-8510, 82-8512, 82-8519. Unpublished report prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA. (1982b).
    • (1982) V-79 Mammalian Cell Mutagenesis Assay with Abamectin (MK 0936)
    • Gordon, L.R.1    Bradley, M.O.2    Patterson, S.3
  • 26
    • 77953286737 scopus 로고
    • Study No. TT 82-8520, 82-8523, 82-8525, 82-8526. Unpublished report prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA
    • Gordon LR, Bradley MO, Patterson SK, Taylor VE, Dysart GR: In vitro alkaline elution/rat hepatocyte assay with abamectin (MK 0936). Study No. TT 82-8520, 82-8523, 82-8525, 82-8526. Unpublished report prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA. (1982d).
    • (1982) In Vitro Alkaline Elution/rat Hepatocyte Assay with Abamectin (MK 0936)
    • Gordon, L.R.1    Bradley, M.O.2    Patterson, S.K.3    Taylor, V.E.4    Dysart, G.R.5
  • 27
    • 77953291518 scopus 로고
    • Chinese hamster ovary cells Study No TT 85-8631, 85-8632, 85-8635. Unpublished report prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA
    • Gordon LR, Galloway S, Patterson SK, Armstrong M, Bean CL, Deasy D: Abamectin (MK 0936) assay for chromosomal aberrations in vitro, in Chinese hamster ovary cells Study No. TT 85-8631, 85-8632, 85-8635. Unpublished report prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA. (1985a).
    • (1985) Abamectin (MK 0936) Assay for Chromosomal Aberrations in Vitro
    • Gordon, L.R.1    Galloway, S.2    Patterson, S.K.3    Armstrong, M.4    Bean, C.L.5    Deasy, D.6
  • 28
    • 77953291043 scopus 로고
    • Study No. TT 85-8005 and 85-805. Unpublished reports prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA
    • Gordon LR, Sina J, Patterson S, Berglind R, Prato M, Quillin F: Microbial mutagenesis assays with abamectin (avermectin B1; MK 0936). Study No. TT 85-8005 and 85-805. Unpublished reports prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA. (1985b).
    • (1985) Microbial Mutagenesis Assays with Abamectin (Avermectin B1; MK 0936)
    • Gordon, L.R.1    Sina, J.2    Patterson, S.3    Berglind, R.4    Prato, M.5    Quillin, F.6
  • 30
    • 0029145392 scopus 로고
    • Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component
    • Ikeda H, Ǒmura S: Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. J Antibiot 48: 549-562 (1995).
    • (1995) J Antibiot , vol.48 , pp. 549-562
    • Ikeda, H.1    Ǒmura, S.2
  • 31
    • 0031273440 scopus 로고    scopus 로고
    • Avermectin biosynthesis
    • Ikeda H, Ǒmura S: Avermectin biosynthesis. Chem Rev 97: 2591-2610 (1997).
    • (1997) Chem Rev , vol.97 , pp. 2591-2610
    • Ikeda, H.1    Ǒmura, S.2
  • 32
    • 0038561132 scopus 로고    scopus 로고
    • Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
    • Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, et al: Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis . Nat Biotechnol 21: 526-531 (2003).
    • (2003) Nat Biotechnol , vol.21 , pp. 526-531
    • Ikeda, H.1    Ishikawa, J.2    Hanamoto, A.3    Shinose, M.4    Kikuchi, H.5
  • 33
    • 0006585405 scopus 로고    scopus 로고
    • ILSI, (International Life Science Institute, Washington, DC)
    • ILSI: A Framework for Cumulative Risk Assessment, pp 1-62 (International Life Science Institute, Washington, DC 1999).
    • (1999) A Framework for Cumulative Risk Assessment , pp. 1-62
  • 34
    • 0024469793 scopus 로고
    • Analysis of chromosome aberrations and sister-chromatid exchanges in peripheral blood lymphocytes of workers with occupational exposure to the mancozeb-containing fungicide Novozir Mn80
    • Jablonická A, Poláková H, Karelová J, Vargová M: Analysis of chromosome aberrations and sister-chromatid exchanges in peripheral blood lymphocytes of workers with occupational exposure to the mancozeb-containing fungicide Novozir Mn80. Mutat Res 224: 143-146 (1989).
    • (1989) Mutat Res , vol.224 , pp. 143-146
    • Jablonická, A.1    Poláková, H.2    Karelová, J.3    Vargová, M.4
  • 35
    • 34247174792 scopus 로고    scopus 로고
    • Sub-lethal toxicity of the antiparasitic abamectin on earthworms and the application of neutral red retention time as a biomarker
    • Jensen J, Diao X, Scott-Fordsmand JJ: Sub-lethal toxicity of the antiparasitic abamectin on earthworms and the application of neutral red retention time as a biomarker. Chemosphere 68: 744-750 (2007).
    • (2007) Chemosphere , vol.68 , pp. 744-750
    • Jensen, J.1    Diao, X.2    Scott-Fordsmand, J.J.3
  • 37
    • 34247215645 scopus 로고    scopus 로고
    • Advances in drug discovery and biochemical studies
    • Kita K, Shiomi K, Omura S: Advances in drug discovery and biochemical studies. Trends Parasitol 23: 223-229 (2007).
    • (2007) Trends Parasitol , vol.23 , pp. 223-229
    • Kita, K.1    Shiomi, K.2    Omura, S.3
  • 38
    • 58549108802 scopus 로고    scopus 로고
    • The in vitro genotoxic effects of a commercial formulation of alpha-cypermethrin in human peripheral blood lymphocytes
    • Kocaman AY, Topaktaş M: The in vitro genotoxic effects of a commercial formulation of alpha-cypermethrin in human peripheral blood lymphocytes. Environ Mol Mutagen 50: 27-36 (2009).
    • (2009) Environ Mol Mutagen , vol.50 , pp. 27-36
    • Kocaman, A.Y.1    Topaktaş, M.2
  • 39
    • 0347031126 scopus 로고    scopus 로고
    • A comparative study of effects of Aversectin C, Abamectin and Ivermectin on apoptosis of rat thymocytes induced by radiation and dexamethasone
    • Korystov YN, Mosin VA, Shaposhnikova VV, Levitman MK, Kudryavtsev AA, et al: A comparative study of effects of Aversectin C, Abamectin and Ivermectin on apoptosis of rat thymocytes induced by radiation and dexamethasone. Acta Vet Brno 68: 23-29 (1999).
    • (1999) Acta Vet Brno , vol.68 , pp. 23-29
    • Korystov, Y.N.1    Mosin, V.A.2    Shaposhnikova, V.V.3    Levitman, M.K.4    Kudryavtsev, A.A.5
  • 41
    • 0001810813 scopus 로고
    • Toxicology
    • Campbell WC (ed) (Springer-Verlag, New York)
    • Lankas GR, Gordon LR: Toxicology, in Campbell WC (ed): Ivermectin and Abamectin, pp 89-112 (Springer-Verlag, New York 1989).
    • (1989) Ivermectin and Abamectin , pp. 89-112
    • Lankas, G.R.1    Gordon, L.R.2
  • 42
    • 34347401839 scopus 로고    scopus 로고
    • Nematode ligand-gated chloride channels: An appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers
    • McCavera S, Walsh TK, Wolstenholme AJ: Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers. Parasitology 134: 1111-1121 (2007).
    • (2007) Parasitology , vol.134 , pp. 1111-1121
    • McCavera, S.1    Walsh, T.K.2    Wolstenholme, A.J.3
  • 44
    • 77953285790 scopus 로고
    • Merck and Co. I. TT #79-8034. Unpublished study; submitted to WHO by Merck & Co., Inc.
    • Merck and Co. I: MK-0933: Mouse lymphoma cytotoxicity study. TT #79-8034. Unpublished study; submitted to WHO by Merck & Co., Inc. (1980a).
    • (1980) MK-0933: Mouse Lymphoma Cytotoxicity Study
  • 45
    • 28844509176 scopus 로고
    • Merck and Co. I, TT #80-8205. Unpublished study; submitted to WHO by Merck & Co., Inc.
    • Merck and Co. I: MK 933: Unscheduled DNA synthesis in human IMR90-fibroblasts. TT #80-8205. Unpublished study; submitted to WHO by Merck & Co., Inc. (1980b).
    • (1980) MK 933: Unscheduled DNA Synthesis in Human IMR90-fibroblasts
  • 46
    • 28844472327 scopus 로고
    • Merck and Co. I, TT #83-002,-0, -1, -2, -3. Unpublished study; submitted to WHO by Merck & Co., Inc.
    • Merck and Co. I: Ninety-four week dietary carcinogenicity and toxicity study in mice. TT #83-002,-0, -1, -2, -3. Unpublished study; submitted to WHO by Merck & Co., Inc. (1983).
    • (1983) Ninety-four Week Dietary Carcinogenicity and Toxicity Study in Mice
  • 47
    • 0018398943 scopus 로고
    • Avermectins, new family of potent anthelmintic agents: Isolation and chromatographic properties
    • Miller TW, Chaiet L, Cole DJ, Cole LJ, Flor JE, et al: Avermectins, new family of potent anthelmintic agents: isolation and chromatographic properties. Antimicrob Agents Chemother 15: 368-371 (1979).
    • (1979) Antimicrob Agents Chemother , vol.15 , pp. 368-371
    • Miller, T.W.1    Chaiet, L.2    Cole, D.J.3    Cole, L.J.4    Flor, J.E.5
  • 48
    • 64549113452 scopus 로고    scopus 로고
    • In vitro genotoxic and cytotoxic effects of ivermectin and its formulation ivomec on Chinese hamster ovary (CHOK1) cells
    • Molinari G, Soloneski S, Reigosa MA, Larramendy ML: In vitro genotoxic and cytotoxic effects of ivermectin and its formulation ivomec on Chinese hamster ovary (CHOK1) cells. J Hazard Mater 165: 1074-1082 (2009).
    • (2009) J Hazard Mater , vol.165 , pp. 1074-1082
    • Molinari, G.1    Soloneski, S.2    Reigosa, M.A.3    Larramendy, M.L.4
  • 49
    • 0036973250 scopus 로고    scopus 로고
    • Lymphatic filariasis elimination: Progress in global programme development
    • Molyneux DH, Zagaria N: Lymphatic filariasis elimination: progress in global programme development. Ann Trop Med Parasitol 96:S15-S40 (2002).
    • (2002) Ann Trop Med Parasitol , vol.96
    • Molyneux, D.H.1    Zagaria, N.2
  • 50
    • 3142747613 scopus 로고    scopus 로고
    • Disease eradication, elimination and control: The need for accurate and consistent usage
    • Molyneux DH, Hopkins DR, Zagaria N: Disease eradication, elimination and control: the need for accurate and consistent usage. Trends Parasitol 20: 347-351 (2004).
    • (2004) Trends Parasitol , vol.20 , pp. 347-351
    • Molyneux, D.H.1    Hopkins, D.R.2    Zagaria, N.3
  • 52
    • 34250632081 scopus 로고    scopus 로고
    • Efficacy and safety of drug combinations in the treatment of schistosomiasis, soil-transmitted helminthiasis, lymphatic filariasis and onchocerciasis
    • Olsen A: Efficacy and safety of drug combinations in the treatment of schistosomiasis, soil-transmitted helminthiasis, lymphatic filariasis and onchocerciasis. Trans R Soc Trop Med Hyg 101: 747-758 (2007).
    • (2007) Trans R Soc Trop Med Hyg , vol.101 , pp. 747-758
    • Olsen, A.1
  • 53
  • 54
    • 37549071056 scopus 로고    scopus 로고
    • Ivermectin: 25 years and still going strong
    • Ǒmura S: Ivermectin: 25 years and still going strong. Int J Antimicrob Agents 31: 91-98 (2008).
    • (2008) Int J Antimicrob Agents , vol.31 , pp. 91-98
    • Ǒmura, S.1
  • 55
    • 9444230640 scopus 로고    scopus 로고
    • The life and times of ivermectin - A success story
    • Ǒmura S, Crump A: The life and times of ivermectin - a success story. Nat Rev Microbiol 2: 984-989 (2004).
    • (2004) Nat Rev Microbiol , vol.2 , pp. 984-989
    • Ǒmura, S.1    Crump, A.2
  • 56
    • 0035834039 scopus 로고    scopus 로고
    • Genome sequence of an industrial microorganism Streptomyces avermitilis : ddeducing the ability of producing secondary metabolites
    • Ǒmura S, Ikeda H, Ishikawa J, Hanamoto A, Takahashi C, et al: Genome sequence of an industrial microorganism Streptomyces avermitilis : deducing the ability of producing secondary metabolites. Proc Natl Acad Sci USA 98: 12215-12220 (2001).
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12215-12220
    • Ǒmura, S.1    Ikeda, H.2    Ishikawa, J.3    Hanamoto, A.4    Takahashi, C.5
  • 59
    • 77953288407 scopus 로고
    • Study No. TT 76-8052. Unpublished report prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA
    • Skeggs H: Microbial mutagenesis assay with avermectin B1a (C-076(B1a)). Study No. TT 76-8052. Unpublished report prepared by Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania, USA. Submitted to WHO by MSDRL, Three Bridges, NJ, USA. (1976).
    • (1976) Microbial Mutagenesis Assay with Avermectin B1a (C-076(B1a)
    • Skeggs, H.1
  • 60
    • 0035175420 scopus 로고    scopus 로고
    • Effect of the dithiocarbamate pesticide zineb and its commercial formulation azzurro I. Genotoxic evaluation on cultured human lymphocytes exposed in vitro
    • Soloneski S, González M, Piaggio E, Apezteguía M, Reigosa MA, Larramendy ML: Effect of the dithiocarbamate pesticide zineb and its commercial formulation azzurro. I. Genotoxic evaluation on cultured human lymphocytes exposed in vitro. Mutagenesis 16: 487-493 (2001).
    • (2001) Mutagenesis , vol.16 , pp. 487-493
    • Soloneski, S.1    González, M.2    Piaggio, E.3    Apezteguía, M.4    Reigosa, M.A.5    Larramendy, M.L.6
  • 64
    • 20444370281 scopus 로고    scopus 로고
    • Synthesis of new, potent avermectin-like insecticidal agents
    • Wei L, Wei G, Zhang H, Wang PG, Du Y: Synthesis of new, potent avermectin-like insecticidal agents. Carbohydr Res 340: 1583-1590 (2005).
    • (2005) Carbohydr Res , vol.340 , pp. 1583-1590
    • Wei, L.1    Wei, G.2    Zhang, H.3    Wang, P.G.4    Du, Y.5
  • 66
    • 36448933464 scopus 로고    scopus 로고
    • The challenges of developing novel antiparasitic drugs
    • Woods DJ, Williams TM: The challenges of developing novel antiparasitic drugs. Invert Neurosci 7: 245-250 (2007).
    • (2007) Invert Neurosci , vol.7 , pp. 245-250
    • Woods, D.J.1    Williams, T.M.2
  • 67
    • 61549126414 scopus 로고    scopus 로고
    • In vitro acute cytotoxicity of abamectin to the Gill Cell Line of Flounder Paralichthy olivaceus
    • Xu Y, Guo H, Xiao Q, Su F, Yin L: In vitro acute cytotoxicity of abamectin to the Gill Cell Line of Flounder Paralichthy olivaceus . J Ocean Univ China 6: 369-372 (2007).
    • (2007) J Ocean Univ China , vol.6 , pp. 369-372
    • Xu, Y.1    Guo, H.2    Xiao, Q.3    Su, F.4    Yin, L.5
  • 68
    • 1542269182 scopus 로고    scopus 로고
    • Avermectin: Biochemical and molecular basis of its biosynthesis and regulation
    • Yoon YJ, Kim ES, Hwang YS, Choi CY: Avermectin: biochemical and molecular basis of its biosynthesis and regulation. Appl Microbiol Biotechnol 63: 626-634 (2004).
    • (2004) Appl Microbiol Biotechnol , vol.63 , pp. 626-634
    • Yoon, Y.J.1    Kim, E.S.2    Hwang, Y.S.3    Choi, C.Y.4
  • 69
    • 33749177715 scopus 로고    scopus 로고
    • Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis
    • Zhang X, Chen Z, Li M, Wen Y, Song Y, Li J: Construction of ivermectin producer by domain swaps of avermectin polyketide synthase in Streptomyces avermitilis . Appl Microbiol Biotechnol 72: 986-994 (2006).
    • (2006) Appl Microbiol Biotechnol , vol.72 , pp. 986-994
    • Zhang, X.1    Chen, Z.2    Li, M.3    Wen, Y.4    Song, Y.5    Li, J.6


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