Mode of Action of Avermectin

Macrolide Antibiotics: Chemistry, Biology, and Practice: Second Edition

Volumn , Issue , 2003, Pages 571-576

  Omura, Satoshi ^a  

^a KITASATO UNIVERSITY   (Japan)

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EID: 84904225573     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012526451-8/50014-X     Document Type: Chapter

References (13)

1. Turner M., Schaeffer J.M. Mode of action of invermectin. Ivermectin and Avermectin 1989, 73-88. Springer-Verlag, New York. W.C. Campbell (Ed.).
2. Fritz L.C., Wang C.C., Girio A. Avermectin B 1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Proc. Natl. Acad. Sci. USA 1979, 76:2062-2066.
3. Mellin T.N., Busch R.D., Wang C.C. Postsynaptic inhibition of invertebrate neuromuscular transmission by avermectin B1a. Neuropharmacology 1983, 22:89-96.
4. Kass I.S., Wang C.C., Walrond J.P., Stretton A.O.W. Avermectin B1a, a paralyzing anthelmintic that affects interneurons and inhibitory motoneurons in Ascaris. Proc. Natl. Acad. Sci. USA 1983, 77:6211-6215.
5. Duce I.R., Scott R.H. Actions of dihydroavermectin B1a on insect muscle. Br. J. Pharmacol. 1985, 85:395-401.
6. Pong S.S., Wang C.C. The specificity of high affinity binding of avermectin B1a to mammalian brain. Neuropharmacology 1980, 19:311-317.
7. 3H]avermectin B1a. Eur. J. Pharmacol. 1984, 99:269-277.
8. Schaeffer J.M., Haines H.W. Avermectin binding in Caenorhabditis elegans. A two-state mode for the avermectin binding site. Biochem. Pharmacol. 1989, 38:2329-2338.
9. Arena J.P., Liu K.K., Paress P.S., Cully D.F. Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes. Mol. Pharmacol. 1991, 40:368-374.
10. Arena J.P., Liu K.K., Paress P.S., Schaeffer J.M., Cully D.F. Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: Evidence for modulation by avermectin. Mol. Brain Res. 1992, 15:339-348.
11. Rohrer S.P., Meinke P.T., Hayes E.C., Mrozik H., Schaeffer J.M. Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster. Proc. Natl. Acad. Sci. USA. 1992, 89:4168-4172.
12. Cully D.F., Vassilatis D.K., Liu K.K., Paress P.S., Van der Ploeg L.H.V., Schaeffer J.M., Arena J.P. Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature 1994, 371:707-711.
13. Cully D.F., Paress P.S., Liu K.K., Schaeffer J.M., Arena J.P. Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. J. Biol. Chem. 1996, 271:20,187-20,191.