Endothelin-1 Aggravates Hepatic Ischemia/Reperfusion Injury During Obstructive Cholestasis in Bile Duct Ligated Mice

Journal of Surgical Research

Volumn 162, Issue 1, 2010, Pages 46-53

  Nagai, Hiroyuki ^a   Kato, Atsushi ^a   Kimura, Fumio ^a   Shimizu, Hiroaki ^a   Yoshidome, Hiroyuki ^a   Ohtsuka, Masayuki ^a   Furukawa, Katsunori ^a   Nozawa, Satoshi ^a   Yoshitomi, Hideyuki ^a   Mitsuhashi, Noboru ^a   Takeuchi, Dan ^a   Suda, Kosuke ^a   Yoshioka, Isaku ^a   Miyazaki, Masaru ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

endothelin 1; hepatic ischemia reperfusion; hepatic stellate cell; microcirculatory disturbance; neutrophil; obstructive cholestatic liver

Indexed keywords

ENDOTHELIN 1; MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CELL ACTIVATION; CHOLESTASIS; CONTROLLED STUDY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LIVER INJURY; LIVER ISCHEMIA; LIVER RESECTION; MALE; MICROCIRCULATION; MORBIDITY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; RISK FACTOR; STELLATE CELL; SURGICAL MORTALITY;

ANIMALS; CHEMOKINES, CXC; CHOLESTASIS; COMMON BILE DUCT; ENDOTHELIN-1; HEPATIC STELLATE CELLS; LIGATION; LIVER; LIVER DISEASES; MALE; MICE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; REPERFUSION INJURY;

EID: 77953288875     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.07.024     Document Type: Article

References (36)

1. Hofmann A.F. Cholestatic liver disease: Pathophysiology and therapeutic options. Liver 22 (2002) 14
2. Nagino M., Kamiya J., Uesaka K., et al. Complications of hepatectomy for hilar cholangiocarcinoma. World J Surg 25 (2001) 1277
3. Das B.C., Isaji S., and Kawarada Y. Analysis of 100 consecutive hepatectomies: Risk factor in patients with liver cirrhosis or obstructive jaundice. World J Surg 25 (2001) 266
4. Pringle J.H. Notes on the arrest of hepatic hemorrhage due to trauma. Ann Surg 48 (1908) 541
5. Belghiti J., Noun R., Malafosse R., et al. Continuous versus intermittent portal triad clamping for liver resection: A controlled study. Ann Surg 229 (1999) 369
6. Belghiti J., Noun R., Zante E., et al. Portal triad clamping or hepatic vascular exclusion for major liver resection. A controlled study. Ann Surg 224 (1996) 155
7. Lentsch A.B., Kato A., Yoshidome H., et al. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 32 (2000) 169
8. Lentsch A.B., Yoshidome H., Cheadle W.G., et al. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: Roles for macrophage inflammatory protein-2 and KC. Hepatology 27 (1998) 507
9. Okaya T., and Lentsch A.B. Cytokine cascades and the hepatic inflammatory response to ischemia and reperfusion. J Invest Surg 16 (2003) 141
10. Gujral J.S., Farhood A., Bajt M.L., et al. Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice. Hepatology 38 (2003) 355
11. Cutrn J.C., Perrelli M.G., Cavalieri B., et al. Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning. Free Radic Biol Med 33 (2002) 1200
12. Yanagisawa M., Kurihara H., Kimura S., et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332 (1988) 411
13. Rockey D.C. Vascular mediators in the injured liver. Hepatology 37 (2003) 4
14. Pinzani M., Milani S., De Franco R., et al. Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 110 (1996) 534
15. Okumura S., Takei Y., Kawano S., et al. Vasoactive effect of endothelin-1 on rat liver in vivo. Hepatology 19 (1994) 155
16. Rockey D.C., Fouassier L., Chung J.J., et al. Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells. Hepatology 27 (1998) 472
17. Asbert M., Gines A., Gines P., et al. Circulating levels of endothelin in cirrhosis. Gastroenterology 104 (1993) 1485
18. Burt A.D. Pathobiology of hepatic stellate cells. J Gastroenterol 34 (1999) 299
19. Rockey D.C., and Weisiger R.A. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: Implications for regulation of portal pressure and resistance. Hepatology 24 (1996) 233
20. Tsuchiya Y., Suzuki S., Inaba K., et al. Impact of endothelin-1 on microcirculatory disturbance after partial hepatectomy under ischemia/reperfusion in thioacetamide-induced cirrhotic rats. J Surg Res 111 (2003) 100
21. Schierwagen C., Bylund-Fellenius A.C., and Lundberg C. Improved method for quantification of tissue PMN accumulation measured by myeloperoxidase activity. J Pharmacol Methods 23 (1990) 179
22. Jaeschke H., and Smith C.W. Mechanisms of neutrophil-induced parenchymal cell injury. J Leukoc Biol 61 (1997) 647
23. Camargo Jr. C.A., Madden J.F., Gao W., et al. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 26 (1997) 1513
24. Yoshidome H., Miyazaki M., Shimizu H., et al. Obstructive jaundice impairs hepatic sinusoidal endothelial cell function and renders liver susceptible to hepatic ischemia/reperfusion. J Hepatol 33 (2000) 59
25. Georgiev P., Navarini A., Eloranta J.J., et al. Cholestasis protects the liver from ischaemic injury and postischemic inflammation in the mouse. Gut 56 (2007) 121
26. Nakamura S., Nishiyama R., Serizawa A., et al. Hepatic release of endothelin-1 after warm ischemia. Reperfusion injury and its hemodynamic effect. Transplantation 59 (1995) 679
27. Uhlmann D., Witzigmann H., Senninger N., et al. Protective role of an endothelin-converting enzyme inhibitor (FR901533) in hepatic ischemia/reperfusion injury. Microvasc Res 62 (2001) 43
28. Yanagisawa M. The endothelin systemA new target for therapeutic intervention. Circulation 89 (1994) 1320
29. Sakurai T., Yanagisawa M., and Masaki T. Molecular characterization of endothelin receptors. Trends Pharmacol Sci 13 (1992) 103
30. Stephenson K., Harvey S.A., Mustafa S.B., et al. Endothelin association with the cultured rat Kupffer cell: Characterization and regulation. Hepatology 22 (1995) 896
31. Housset C., Rockey D.C., and Bissell D.M. Endothelin receptors in rat liver: Lipocytes as a contractile target for endothelin 1. Proc Natl Acad Sci 90 (1993) 9266
32. Kawada N., Tran-Thi T.A., Klein H., et al. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus. Eur J Biochem 213 (1993) 815
33. Gerbes A.L., Moller S., Gulberg V., et al. Endothelin-1 and -3 plasma concentrations in patients with cirrhosis: Role of splanchnic and renal passage and liver function. Hepatology 21 (1995) 735
34. Gandhi C.R., Sproat L.A., and Subbotin V.M. Increased hepatic endothelin-1 levels and endothelin receptor density in cirrhotic rats. Life Sci 58 (1996) 55
35. Leivas A., Jimenez W., Bruix J., et al. Gene expression of endothelin-1 and ET (A) and ET (B) receptors in human cirrhosis: Relationship with hepatic hemodynamics. J Vasc Res 35 (1998) 186
36. Tieche S., De Gottardi A., Kappeler A., et al. Overexpression of endothelin-1 in bile duct ligated rats: Correlation with activation of hepatic stellate cells and portal pressure. J Hepatol 34 (2001) 38