Pathobiology of hepatic stellate cells

Journal of Gastroenterology

Volumn 34, Issue 3, 1999, Pages 299-304

  Burt, Alastair D ^a  

^a NONE

Author keywords

Antifibrotic therapy; Cell signalling; Hepatic stellate cells; Liver fibrosis

Indexed keywords

ALPHA INTERFERON; ALPHA TOCOPHEROL; ANTIFIBROTIC AGENT; LUFIRONIL; PENTOXIFYLLINE; RETINOID DERIVATIVE; RETINOL PALMITATE; SAFRINIL; SILIBININ; UNCLASSIFIED DRUG; XIAO CHAI HU TANG;

CELL ACTIVATION; CELL FUNCTION; CELL STRUCTURE; HUMAN; HUMAN CELL; ITO CELL; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; PATHOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; STELLATE CELL;

ANIMALS; CHRONIC DISEASE; HUMANS; KUPFFER CELLS; LIVER CIRRHOSIS; MICE; PROGNOSIS; RATS; REFERENCE VALUES;

EID: 0032774537     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005350050264     Document Type: Review

References (63)

1. Ito T, Nemeto J. Uber die Kupfferschen Sternzellen und die "Fettspeicherungszellen" (fat-storing cells) in der Blutkapillarenwand der menschlichen Leber. Okajima's Folia Anat Jpn 1952;24:243-58.
2. Yamagishi M. Electron microscopic studies on the fine structure of the sinusoidal wall and fat-storing cells of rabbit livers. Arch Histol Jpn 1959;18:679-92.
3. Aterman K. The parasinusoidal cells of the liver: a historical account. Histochem J 1986;18:279-305.
4. Ahern M, Hall P, Halliday M, Liddle C, Olynyk J, et al. Hepatic stellate cell nomenclature. Hepatology 1996;23:193.
5. Burt AD. Cellular and molecular aspects of hepatic fibrosis. CL Oakley Lecture. J Pathol 1993;170:105-14.
6. Wake K. Perisinusoidal stellate fat-storing cells, interstitial cells, lipocytes, their related structure in and around the liver sinusoids and vitamin A-storing cells in extrahepatic organs. Int Rev Cytol 1980;66:303-33.
7. Yokoi Y, Namihisa T, Kuroda H, Komatsu I, Miyazaki A, Watanabe S, Usui K. Immunocytochemical detection of desmin in fat-storing Ito cells. Hepatology 1984;4:709-14.
8. Ogawa K, Suzuki J, Mukai H, Mori M. Sequential changes of extracellular matrix and proliferation of Ito cells with enhanced expression of desmin and actin in focal hepatic injury. Am J Pathol 1986;125:611-9.
9. Burt AD, Robertson JL, Heir J, MacSween RNM. Desmincontaining stellate cells in rat liver: distribution in normal animals and response to experimental acute liver injury. J Pathol 1986;150:29-35.
10. Schmitt-Gräff A, Krüger S, Bochard F, Gabbiani G, Denk H. Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol 1991;138:1233-42.
11. Buniatian G, Hamprecht B, Gebhardt R. Glial fibrillary acidic protein as a marker of perisinusoidal stellate cells that can distinguish between the normal and myofibroblast-like phenotypes. Biol Cell 1996;87:65-73.
12. Niki T, Pekny M, Eliasson C, De Bleser P, Van den Berg K, Geerts A. Dependence of desmin steady state levels on glial fibrillary acidic protein in mouse hepatic stellate cells (abstract). Hepatology 1998;28:511.
13. Aoki T, Hagiawara H, Fujimoto T. Peculiar distribution of fodrin in fat-storing cells. Exp Cell Res 1997;234:313-20.
14. Rockey DC. The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide. Hepatology 1997;25:2-5.
15. Rockey DC, Weisiger RA. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. Hepatology 1996;24:233-40.
16. Mathew J, Geerts A, Burt AD. Pathobiology of hepatic stellate cells. Hepatogastroenterology 1996;43:72-91.
17. Zou ZZ, Ekataksin W, Wake K. Zonal and regional differences identified from precision mapping of vitamin A-storing lipid droplets of the hepatic stellate cells in pig liver: a novel concept of addressing the intralobular area of heterogeneity. Hepatology 1998;27:1098-108.
18. Ballardini G, Groff P, Badiali de Giorgi LB, Schuppan D, Bianchi FB. Ito cell heterogeneity: desmin-negative Ito cells in normal rat liver. Hepatology 1994;19:440-6.
19. Schirmacher P, Geerts A, Pietrangelo A, Dienes HP, Rogler CE. Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells. Hepatology 1992;15:5-11.
20. Skrtic S, Wallenius V, Ekberg S, Brenzel A, Gressner AM, Jansson JO. Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta 1 in cultured hepatic stellate cells. Endocrinology, 1997;138:4683-9.
21. Ikeda H, Nagoshi S, Ohno A, Yanase M, Maekawa H, Fujiwara K. Activated rat stellate cells express c-met and respond to hepa-tocyte growth factor to enhance transforming growth factor beta expression and DNA synthesis. Biochem Biophys Res Commun 1998;250:769-75.
22. Blunchet I, Wake K. Role of mesenchymal cell populations in procine serum-induced rat liver fibrosis. Hepatology 1992;16: 1452-73.
23. Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, et al. Identification, culture and characterisation of pancreatic stellate cells in rats and humans. Gastroenterology 1998;115:421-32.
24. Nagy NE, Holven KB, Roos N, Senoo H, Kojima N, Norum KR, Blomhoff R. Storage of vitamin A in extrahepatic stellate cells in normal rats. J Lipid Res 1997;38:645-58.
25. Geerts A, Niki T, Hellemans K, DeGraemer D, Van den Berg K, Lazou J-M, et al. Purification of rat hepatic stellate cells by side scatter-activated cell sorting. Hepatology 1998;27:590-8.
26. Johnson SJ, Hines JE, Burt AD. Macrophage and perisinusoidal cell kinetics in acute liver injury. J Pathol 1992;166:351-8.
27. Johnson SJ, Hines JE, Burt AD. Phenotypic modulation of perisinusoidal cells following acute liver injury: a quantitative analysis. Int J Exp Pathol 1992;73:765-72.
28. Enzan H, Himeno H, Iwamura S, Saibara T, Onishi S, Yamamoto Y, Hara H. Immunohistochemical identification of Ito cells and their myofibroblastic transformation in adult human liver. Virchows Arch A 1994;424:249-56.
29. Mathew J, Hines JE, James OFW, Burt AD. Non-parenchymal cell responses in paracetamol-(acetaminophen)-induced liver injury. J Hepatol 1994;20:536-41.
30. Musso O, Rehu M, Saarela J, Théret N, Liétard J, Hintikka TJ, et al. Collagen XVIII is localised in sinusoids and basement membrane zones and expressed by hepatocytes and activated stellate cells in fibrotic human liver. Hepatology 1998;28:98-107.
31. Arthur MJ. Collagenases and liver fibrosis. J Hepatol 1995; 22(Suppl):43-8.
32. Theret N, Musso O, L'Helgouale'h A, Clement B. Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes. Am J Pathol 1997;150:51-8.
33. Lalazar A, Wong L, Yamasaki G, Friedman SL. Early genes induced in hepatic stellate cells during wound healing. Gene 1997;195:235-43.
34. Watanabe S, Hirose M, Wang XE, Ikejima K, Oide H, Kitamura T, et al. A novel hepatic stellate (Ito) cell-derived protein, epimorphin, plays a key role in the late stages of liver regeneration. Biochem Biophys Res Commun 1998;250:486-90.
35. Potter JJ, Womack L, Mezey E, Anania FA. Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 1998;244:178-82.
36. Ikeda K, Kawada N, Wang YQ, Kadoya H, Nakatani K, Sato M, Kaneda K. Expression of cellular prion protein in activated hepatic stellate cells. Am J Pathol 1999 (in press).
37. Ratziu V, Lalazai A, Wong L, Dang Q, Collins C, Shanhan E, el al. Zf9, a Kruppel-like transcription factor up regulated in vivo during early hepatic fibrosis. Proc Natl Acad Sci USA 1998;95:9500-5.
38. Gressner AM. Mediators of hepatic fibrogenesis. Hepatoastroenterology 1996;43:92-103.
39. Gressner AM, Lotfi S, Gressner G, Lahme B. Identification and partial characterisation of a hepatocyte-derived factor promoting proliferation of cultures of fat storing cells (parasinusoidal lipocytes). Hepatology 1992;16:1250-66.
40. Marra F, Grandaliano G, Valente AJ, Abboud HE. Thrombin stimulates proliferation of fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury. Hepatology 1995;22:780-7.
41. Baroni GS, D'Ambrosio L, Ferretti G, Casini A, Di Sario A, Salzano R, et al. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology 1998;27:720-6.
42. Olaso E, Friedman SL. Molecular regulation of hepatic fibrogenesis. J Hepatol 1998;29:836-47.
43. Farrell DJ, Hines JE, Walls AF, Kelly PJ, Bennett MK, Burt AD. Intrahepatic mast cells in chronic liver diseases. Hepatology 1995;22:1175-81.
44. Pinzani M, Milani S, De Franco R, Grappone C, Caligiuri A, Gentilini A, et al. Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 1996;110:534-48.
45. Marra F, Romanelli RG, Pastacaldi S, Failli P, Pinzani M, Laffi G, et al. Monocyte chemotactic protein-1 stimulates hepatic stellate cell migration. J Hepatol 1998;28(Suppl 1):57.
46. Roth S, Eichorn Kuhl K, Gressner AM. Subcellular localization of (latent) TGF-beta and latent TGF-beta binding protein (LTBP-1) in rat hepatocytes and hepatic stellate cells. Hepatology 1998;28:1588-96.
47. Pinzani M, Marra F, Carloni V. Signal transduction in hepatic stellate cells. Liver 1998;18:2-13.
48. Reeves HL, Peak M, Burt AD, Day CP. The role of stress-activated protein kinases in the activation of hepatic stellate cells. Hepatology 1997;26:1277.
49. Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, et al. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell Biol 1997;1:25-34.
50. Saile B, Knittel T, Mathes N, Schott P, Ramadori G. CD95/CD95L-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair. Am J Pathol 1997;151:1265-72.
51. Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, et al. Mechanisms of spontaneous resolution of rat liver fibrosis: hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998;102:538-49.
52. Louis H, Laethan J-LV, Wu W, Quertinmont E, Degraef C, Van Den Berg K, et al. Interleukin 10 controls neutrophilic infiltration, hepatocyte proliferation and liver fibrosis induced by carbon tetrachloride in mice. Hepatology 1998;28:1607-15.
53. Thompson KC, Trowern A, Fowell A, Marathe M, Haycock K, Arthur MJP, et al. Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin 10 during the course of activation in vitro. Hepatology 1998;28:1518-24.
54. Reeves HL, Peak M, Burt AD, Day CP. Interferon alpha inhibits p38 MAP kinase activity in hepatic stellate cells. Hepatology 1997;26:1276.
55. Fuchs EC, Weyhenmeyer R, Weiner OH. Effects of silirubin and of a synthetic analogue on isolated rat hepatic stellate cells and myofibroblasts. Arz Fors Drug Res 1997;47:1383-7.
56. Wang YJ, Wang SS, Bickel M, Guenzler V, Gerl M, Bissell DM. Two novel antifibrotics, HOE077 and Safironil, modulate stellate cell activation in rat liver injury - differential effects in males and females. Am J Pathol 1998;152:279-87.
57. Houglum K, Venkataramani A, Lyche K, Chojkier M. A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology 1997;113:1069-73.
58. Lee KS, Cottam HB, Houglum K, Wasson DB, Carson D, Chojkier M. Pentoxifylline blocks hepatic stellate cell activation independently of phosphodiesterase inhibitory activity. Am J Physiol (Gastro Liver Physiol) 1997;36:G1094-100.
59. Kayano K, Sakaida I, Uchida K, Okita K. Inhibitory effects of the herbal medicine Sho-saiko-to (TJ-9) on cell proliferation and procollagen gene expressions in cultured rat hepatic stellate cells. J Hepatol 1998;29:642-9.
60. Mizobuchi Y, Shimizu I, Yasuda M, Hori H, Shono M, Ito S. Retinyl palmitate reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum. J Hepatol 1998;29:933-43.
61. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB, Brenner DA. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-suppressor. Hepatology 1998;27:1285-95.
62. Rombouts K, Niki T, Knuttel T, Kestemont J, Ramadori G, Geerts A. Histone deacetylase inhibitor trichostatin A suppresses transdifferentiation of rat stellate cells: analysis of basic working mechanisms (abstract). Hepatology 1998;28:312.
63. Beljaars L, Poelstra K, Weert B, Molema G, Schuppan D, Meijer DKF. The development of novel albumin carriers to hepatic stellate cells by application of cyclopeptide moieties recognising collagen type VI and platelet derived growth factor receptors (abstract). Hepatology 1998;28:313.