Protective role of an endothelin-converting enzyme inhibitor (FR901533) in hepatic ischemia/reperfusion injury

Microvascular Research

Volumn 62, Issue 1, 2001, Pages 43-54

  Uhlmann, Dirk ^a   Witzigmann, Helmut ^a   Senninger, Norbert ^b   Hauss, Jan ^a   Spiegel, Hans Ullrich ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5,6,8,13 TETRAHYDRO 1,6,9,14 TETRAHYDROXY 3 (2 HYDROXYPROPYL) 7 METHOXY 8,13 DIOXOBENZO[A]NAPHTHACENE 2 CARBOXYLIC ACID; ENDOTHELIN CONVERTING ENZYME INHIBITOR; LIVER PROTECTIVE AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEMALE; IN VIVO STUDY; LEUKOCYTE; LIVER CELL DAMAGE; LIVER CIRCULATION; LIVER ISCHEMIA; LIVER PERFUSION; LIVER PROTECTION; LIVER SINUSOID; MICROSCOPY; NONHUMAN; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; RAT; REPERFUSION; REPERFUSION INJURY; VASOCONSTRICTION;

RATTUS NORVEGICUS;

EID: 0034913095     PISSN: 00262862     EISSN: None     Source Type: Journal    
DOI: 10.1006/mvre.2001.2309     Document Type: Article

References (40)

1. Measurement of hepatic perfusion in rats by laser Doppler flowmetry
2. Potential roles of endothelin in systemic inflammatory response syndrome with a particular relationship to cytokines
3. Comparative effect of crystalloid and small volume hypertonic hyperoncotic fluid resuscitation on hepatic microcirculation after hemorrhagic shock
4. ET-1 induced alterations of hepatic microcirculation: Sinusoidal and extrasinusoidal sites of action
5. Endothelin-1 induced leukocyte adhesion in submucosal venules of the rat small intestine
6. Effect of endothelin-1 on neutrophil adhesion to endothelial cells and perfused heart
7. Endothelin-1 is involved in the pathogenesis of ischemia/reperfusion liver injury by hepatic microcirculatory disturbances
8. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver
9. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus
10. Response of plasma and tissue endothelin-1 to liver ischemia and its implication in ischemia-reperfusion injury
11. Effects of mixed ETA and ETB-receptor antagonist (Ro-47-0203) on hepatic microcirculation after warm ischemia
12. Relationship between endothelin and thromboxane A2 in rat liver microcirculation
13. Radioimmunological determination of endothelin peptides in human plasma: A methodological approach
14. Reduction by superoxide dismutase of leukocyte-endothelial adherence after liver transplantation
15. Endothelin induction of adhesion molecule expression on human brain microvascular endothelial cells
16. In vivo fluorescence microscopy for quantitative analysis of the hepatic microcirculation in hamsters and rats
17. Dextran versus hydroxyethylstarch in inhibition of postischemic leukocyte adherence in striated muscle
18. Hepatic release of endothelin-1 after warm ischemia
19. Endothelin-1 levels in portal venous blood in relation to hepatic tissue microcirculation disturbances and hepatic cell injury after ischemia/reperfusion
20. Differential impact of Carolina rinse and University of Wisconsin solution on microcirculation, leukocyte adhesion, Kupffer cell activity and biliary excretion after liver transplantation
21. Sinusoidal endothelial liver cells in vitro release endothelin-augmentation by transforming growth factor β and Kupffer cell-conditioned media
22. Influence of hypoxia on hepatic and renal endothelin gene expression
23. Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells
24. Effect of nitric oxide on iron-mediated oxidative stress in primary rat hepatocyte culture
25. Inhibition of endothelin-converting enzyme attenuates transplant vasculopathy and rejection in rat cardiac allografts
26. 2 monitoring in experimental angiology
27. Effect of endothelin receptor antagonist bosentan on postischemic oxygen supply of the liver
28. Effect of endothelin receptor antagonist bosentan on postischemic liver microcirculation
29. WS79089A, B, and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum No. 79089
30. Biological and pharmacological properties of highly selective new endothelin converting enzyme inhibitor WS79089B isolated from Streptosporangium roseum No. 79089
31. Important role for endothelins in acute hepatic ischemia/reperfusion injury
32. Evaluation of hepatic microcirculation by in vivo microscopy
33. Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury
34. Hepatic microcirculatory perfusion failure is a determinant for liver dysfunction in warm ischemia-reperfusion
35. Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence
36. Role of microcirculatory derangements in manifestation of portal triad cross-clamping-induced hepatic reperfusion injury
37. ECE-1: A membrane-bound metalloprotease that catalizes the proteolytic activation of big endothelin-1
38. Molecular biology and biochemistry of the endothelins
39. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
40. Endothelin-1 induces direct constriction of hepatic sinusoids