Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the wobbler mouse

Journal of the Neurological Sciences

Volumn 160, Issue 1, 1998, Pages 9-15

  Ikeda, Ken ^a   Iwasaki, Yasuo ^a   Kinoshita, Masao ^a  

^a TOHO UNIVERSITY   (Japan)

Author keywords

7 Nitroindazole; Motoneuron disease; N(G) Nitro L arginine methyl ester; Nitric oxide synthase; Wobbler mouse

Indexed keywords

3 NITROTYROSINE; 7 NITROINDAZOLE; FREE RADICAL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PEROXYNITRITE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BICEPS BRACHII MUSCLE; CONTROLLED STUDY; GRIP STRENGTH; INTRAPERITONEAL DRUG ADMINISTRATION; MORPHOMETRICS; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HAND STRENGTH; INDAZOLES; MICE; MICE, NEUROLOGIC MUTANTS; MOTOR NEURON DISEASE; MOTOR NEURONS; MUSCLE DENERVATION; MUSCLE, SKELETAL; NERVE TISSUE PROTEINS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; ORGAN SIZE; VACUOLES;

EID: 0032544340     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(98)00224-X     Document Type: Article

References (42)

1. Abe K., Pan L.-H., Watanabe M., Konno H., Kato T., Itoyama Y. Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis. Neurol Res. 19:1997;124-128.
2. + channels and nitric oxide on pial arterioles in piglets. J Cereb Blood Flow Metab. 16:1996;1158-1164.
3. Beal M.F., Ferrante R.J., Browne S.E., Matthews R.T., Kowall N.W., Brown R.H. Jr. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol. 42:1997;646-654.
4. Beckman J.S., Carson M., Smith C.D., Koppenol W.H. ALS, SOD and peroxynitrite. Nature. 364:1993;584.
5. Brown R.H. Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell. 80:1995;687-692.
6. Castagnoli K., Palmer S., Anderson A., Bueters T., Castagnoli N. Jr. The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Chem Res Toxicol. 10:1997;364-368.
7. Clowry G.J., McHanwell S. Expression of nitric oxide synthase by motor neurons in the spinal cord of the mutant mouse wobbler. Neurosci Lett. 215:1996;177-180.
8. Di Monte D.A., Royland J.E., Anderson A., Castagnoli K., Castagnoli N. Jr., Langston J.W. Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole against MPTP neurotoxicity. J Neurochem. 69:1997;1771-1773.
9. Duchen L.W., Strich S.J. An hereditary motor neurone disease with progressive denervation of muscle in the mouse: the mutant 'wobbler'. J Neurol Neurosurg Psychiatry. 31:1968;535-542.
10. Dun N.J., Dun S.L., Forstermann U., Tseng L.F. Nitric oxide synthase immunoreactivity in rat spinal cord. Neurosci Lett. 147:1992;217-220.
11. Estévez A.G., Spear N., Manuel S.M., Radi R., Henderson C.E., Barbeito L., Beckman J.S. Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. J Neurosci. 18:1998;923-931.
12. Gu Y.M., Spasic Z., Wu W.T. The effects of remaining axons on motoneuron survival and NOS expression following in the adult rat. Dev Neurosci. 19:1997;255-259.
13. Hantaz-Ambroise D., Cambier D., Aït-Ikhelf A., Parvy Ph., Murawsky M., Rieger F. Excess extracellular and low intracellular glutamate in poorly differentiating wobbler astrocytes and astrocyte recovery in glutamine-depleted culture medium. J Neurochem. 65:1995;1199-1204.
14. Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., Moskowitz M.A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 265:1994;1883-1885.
15. Igarashi R., Takenaga M., Hoshino J., Ikeda K., Mizushima Y. Free radicals are related to the motor dysfunction in wobbler mice. Inflammation Res. 46(Suppl 3):1997;250.
16. Ikeda K., Iwasaki Y., Tagaya N., Shiojima T., Kinoshita M. Neuroprotective effect of cholinergic differentiation factor/leukemia inhibitory factor (CDF/LIF) on wobbler murine motor neuron disease. Muscle Nerve. 18:1995;1344-1347.
17. Ikeda K., Kinoshita M., Iwasaki Y., Tagaya N., Shiojima T. Lecithinized superoxide dismutase retards wobbler mouse motoneuron disease. Neuromusc Disord. 5:1995;383-390.
18. Ikeda K., Klinkosz B., Greene T., Cedarbaum J.M., Wong V., Lindsay R.M., Mitsumoto H. Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Ann Neurol. 37:1995;505-511.
19. Ikeda K., Wong V., Holmlund T., Greene T., Cedarbaum J.M., Lindsay R.M., Mitsumoto H. Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease. Ann Neurol. 37:1995;47-54.
20. Ikeda K., Kinoshita M., Tagaya N., Shiojima T., Taga T., Yasukawa K., Suzuki H., Okano A. Coadministration of interleukin-6 (IL-6) and soluble IL-6 receptor delays progression of wobbler mouse motor neuron disease. Brain Res. 726:1996;91-97.
21. Ince P., Stout N., Shaw P., Slade J., Hunziker W., Heizmann C.W., Baimbridge K.G. Parvalbumin and calbinden D-28k in human motor system and in motor neuron disease. Neuropathol Appl Neurobiol. 19:1993;291-299.
22. Itzhak Y., Ali S.F. The neuronal nitric oxide synthase inhibitor, 7-nitroindazole, protects against methamphetamine-induced neurotoxicity in vivo. J Neurochem. 67:1996;1770-1773.
23. Iwasaki Y., Ikeda K., Shiojima T., Kobayashi T., Tagaya N., Kinoshita M. Deprenyl and pergolide rescue spinal motor neurons from axotomy-induced neuronal death in the neonatal rats. Neurol Res. 18:1996;168-170.
24. Izumi Y., Benz A.M., Chifford D.B., Zorumski C.F. Nitric oxide inhibitors attenuate N-methyl-D-aspartate excitotoxicity in rat hippocampal slices. Neurosci Lett. 135:1992;227-230.
25. Katchman A.N., Hershkowitz N. Nitric oxide modulates synaptic glutamate release during anoxia. Neurosci Lett. 228:1997;50-54.
26. Kobzik L., Reid M.B., Bredt D.S., Stamler J.S. Nitric oxide in skeletal muscle. Nature. 372:1994;546-548.
27. + channels. Am J Physiol. 271:1996;1498-1506.
28. Koppenol W.H., Moreno J.J., Pryor W.A., Ischiropoulos H., Beckman J.S. Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide. Chem Res Toxicol. 5:1992;834-842.
29. Krieger C., Perry T.L., Hansen S., Mitsumoto H. The wobbler mouse: amino acid contents in the brain and spinal cord. Brain Res. 551:1991;142-144.
30. Lipton S.A., Choi Y.-B., Pan Z.-H., Lei S.Z., Chen H.-S.V., Sucher N.J., Loscalzo J., Singel D.J., Stamler J.S. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature. 364:1993;626-632.
31. Mattson M.P., Cheng B., Smith-Swintosky V.L. Mechanisms of neurotrophic factor protection against calcium- and free radical-mediated excitotoxic injury: implications for treating neurodegenerative disorders. Exp Neurol. 124:1993;89-95.
32. Mitsumoto H., Bradley W.G. The wobbler mouse: the murine motor neuron disease: degeneration and regeneration of the lower motor neuron. Brain. 105:1982;811-834.
33. Mitsumoto H., Ikeda K., Holmlund T., Greene T., Cedarbaum J.M., Wong V., Lindsay R.M. The effect of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Ann Neurol. 36:1994;142-148.
34. Mitsumoto H., Ikeda K., Klinkosz B., Cedarbaum J.M., Wong V., Lindsay R.M. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science. 265:1994;1107-1110.
35. Novikov L., Novikova L., Kellerth J.-O. Brain-derived neurotrophic factor promotes survival and blocks nitric oxide synthase expression in adult rat spinal motoneurons after ventral root avulsion. Neurosci Lett. 200:1995;45-48.
36. Plaitakis A., Constantakakis E., Smith J. The neuroexcitotoxic amino acids glutamate and aspartate are altered in the brain and spinal cord in amyotrophic lateral sclerosis. Ann Neurol. 24:1988;446-449.
37. Rosen D.R., Siddique T., Patterson D.et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 362:1993;59-62.
38. Ruan R.-S., Leong S.-K., Yeoh K.-H. The role of nitric oxide in facial motoneuronal death. Brain Res. 698:1995;163-168.
39. Sasaki M., Facchinetti F., Christov V., Brahmbhatt H., Beal M.F., Reif D., Dawson T.M., Gurney M.E., Dawson V.L. Is neuronal nitric oxide synthase involved in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis? Soc Neurosci Abstr. 22:1996;2142.
40. Tomiyama M., Kannari K., Nunomura J., Oyama Y., Takebe K., Matsunaga M. Quantitative autoradiographic distribution of glutamate receptors in the cervical segment of the spinal cord of the wobbler mouse. Brain Res. 650:1994;353-357.
41. Wu W., Li L. Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion. Neurosci Lett. 153:1993;121-124.
42. Yu W.A. Regulation of nitric oxide synthase expression in motoneurons following nerve injury. Dev Neurosci. 19:1997;247-254.