Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer

Human Pathology

Volumn 41, Issue 7, 2010, Pages 990-1001

  Verbeke, Hannelien ^a   De Hertogh, Gert ^b   Li, Sandra ^a   Vandercappellen, Jo ^a   Noppen, Samuel ^a   Schutyser, Evemie ^a   El Asrar, Ahmed Abu ^b   Opdenakker, Ghislain ^a   Van Damme, Jo ^a   Geboes, Karel ^b   Struyf, Sofie ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Adenocarcinoma of the esophagus; Angiogenesis; Chemokine; Colorectal adenocarcinoma; Squamous cell carcinoma of the esophagus

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; DOUBLE STRANDED RNA; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 8; PEPTIDOGLYCAN; PHORBOL ESTER; STROMAL CELL DERIVED FACTOR 1; THROMBOCYTE FACTOR 4; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CARCINOGENESIS; CARCINOMA CELL; CELL STIMULATION; CELL TYPE; COLON ADENOCARCINOMA; COLORECTAL CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ADENOCARCINOMA; AGED; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CHEMOKINE CXCL12; COLON; COLORECTAL NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-8; MALE; MIDDLE AGED; MUCOUS MEMBRANE; NEOVASCULARIZATION, PATHOLOGIC; PLATELET FACTOR 4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77953285649     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2009.09.021     Document Type: Article

References (34)

1. Zlotnik A., and Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 12 (2000) 121-127
2. Moser B., Wolf M., Walz A., and Loetscher P. Chemokines: multiple levels of leukocyte migration control. Trends Immunol 25 (2004) 75-84
3. Rot A., and von Andrian U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 22 (2004) 891-928
4. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
5. Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat Med 10 (2004) 789-799
6. Raman D., Baugher P.J., Thu Y.M., and Richmond A. Role of chemokines in tumor growth. Cancer Lett 256 (2007) 137-165
7. Strieter R.M., Burdick M.D., Gomperts B.N., Belperio J.A., and Keane M.P. CXC chemokines in angiogenesis. Cytokine Growth Factor Rev 16 (2005) 593-609
8. Schuerer-Maly C.C., Eckmann L., Kagnoff M.F., Falco M.T., and Maly F.E. Colonic epithelial cell lines as a source of interleukin-8: stimulation by inflammatory cytokines and bacterial lipopolysaccharide. Immunology 81 (1994) 85-91
9. Yeruva S., Ramadori G., and Raddatz D. NF-kappaB-dependent synergistic regulation of CXCL10 gene expression by IL-1beta and IFN-gamma in human intestinal epithelial cell lines. Int J Colorectal Dis 23 (2008) 305-317
10. Hellmuth M., Paulukat J., Ninic R., Pfeilschifter J., and Muhl H. Nitric oxide differentially regulates pro- and anti-angiogenic markers in DLD-1 colon carcinoma cells. FEBS Lett 563 (2004) 98-102
11. Brand S., Dambacher J., Beigel F., et al. CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation. Exp Cell Res 310 (2005) 117-130
12. Kelly C.P., Keates S., Siegenberg D., Linevsky J.K., Pothoulakis C., and Brady H.R. IL-8 secretion and neutrophil activation by HT-29 colonic epithelial cells. Am J Physiol 267 (1994) G991-G997
13. Jung H.C., Eckmann L., Yang S.K., et al. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 95 (1995) 55-65
14. Yang S.K., Eckmann L., Panja A., and Kagnoff M.F. Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells. Gastroenterology 113 (1997) 1214-1223
15. Struyf S., Proost P., Vandercappellen J., et al. Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects. Eur J Immunol 39 (2009) 843-857
16. Vandercappellen J., Noppen S., Verbeke H., et al. Stimulation of angiostatic platelet factor-4 variant (CXCL4L1/PF-4var) versus inhibition of angiogenic granulocyte chemotactic protein-2 (CXCL6/GCP-2) in normal and tumoral mesenchymal cells. J Leukoc Biol 82 (2007) 1519-1530
17. Li S., Martens E., Dillen C., Van den Steen P.E., and Opdenakker G. Virus entry inhibition by chlorite-oxidized oxyamylose versus induction of antiviral interferon by poly(I:C). Biochem Pharmacol 76 (2008) 831-840
18. Hamilton S.R., and Aaltonen L.A. WHO Classification of tumours, pathology and genetics of tumours of digestive system (2000), IARC press, Lyon
19. Sobin L.H., and Wittekind C. TNM, Classification of malignant tumours (2002), Wiley-Liss, New York
20. Struyf S., Burdick M.D., Proost P., Van Damme J., and Strieter R.M. Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. Circ Res 95 (2004) 855-857
21. Conway E.M., Collen D., and Carmeliet P. Molecular mechanisms of blood vessel growth. Cardiovasc Res 49 (2001) 507-521
22. Griffioen A.W., and Molema G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 52 (2000) 237-268
23. Gillitzer R., and Goebeler M. Chemokines in cutaneous wound healing. J Leukoc Biol 69 (2001) 513-521
24. Angiolillo A.L., Sgadari C., Taub D.D., et al. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med 182 (1995) 155-162
25. Taub D.D., Lloyd A.R., Conlon K., et al. Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med 177 (1993) 1809-1814
26. Yang X., Chu Y., Wang Y., Zhang R., and Xiong S. Targeted in vivo expression of IFN-gamma-inducible protein 10 induces specific antitumor activity. J Leukoc Biol 80 (2006) 1434-1444
27. Dwinell M.B., Lugering N., Eckmann L., and Kagnoff M.F. Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells. Gastroenterology 120 (2001) 49-59
28. Proost P., Loos T., Mortier A., et al. Citrullination of CXCL8 by peptidylarginine deaminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation. J Exp Med 205 (2008) 2085-2097
29. Romagnani P., Lasagni L., Annunziato F., Serio M., and Romagnani S. CXC chemokines: the regulatory link between inflammation and angiogenesis. Trends Immunol 25 (2004) 201-209
30. Gockel I., Schimanski C.C., Heinrich C., et al. Expression of chemokine receptor CXCR4 in esophageal squamous cell and adenocarcinoma. BMC Cancer 6 (2006) 290
31. Salcedo R., Wasserman K., Young H.A., et al. Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha. Am J Pathol 154 (1999) 1125-1135
32. Kryczek I., Lange A., Mottram P., et al. CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers. Cancer Res 65 (2005) 465-472
33. Ottaiano A., Franco R., Aiello T.A., et al. Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients. Clin Cancer Res 12 (2006) 2795-2803
34. Hong X., Jiang F., Kalkanis S.N., et al. SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion. Cancer Lett 236 (2006) 39-45