Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects

European Journal of Immunology

Volumn 39, Issue 3, 2009, Pages 843-857

  Struyf, Sofie ^a   Proost, Paul ^a   Vandercappellen, Jo ^a   Dempe, Sebastian ^b,c   Noyens, Becky ^a   Nelissen, Sofie ^a   Gouwy, Meike ^a   Locati, Massimo ^d   Opdenakker, Ghislain ^a   Dinsart, Christine ^b,c   Van Damme, Jo ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c Institut National de la Sante et de la Recherche Medicale U701   (Germany)

^d HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

Cell migration; Chemokines; Inflammation; Tumor immunology

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 2[1-76]; MONOCYTE CHEMOTACTIC PROTEIN 2[6-75]; MONOCYTE CHEMOTACTIC PROTEIN 3; PARVOVIRUS VECTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CCL2 PROTEIN, HUMAN; CCL8 PROTEIN, HUMAN; CHEMOKINE RECEPTOR; LIPOPOLYSACCHARIDE; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOTHELIUM CELL; FEMALE; FIBROBLAST; HELA CELL; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION; ANIMAL; CELL LINE; CULTURE MEDIUM; DRUG EFFECT; DRUG POTENTIATION; IMMUNOLOGY; METABOLISM; NEOPLASM; TUMOR CELL LINE;

ANIMALS; CALCIUM; CELL LINE; CELL LINE, TUMOR; CHEMOKINE CCL2; CHEMOKINE CCL8; CULTURE MEDIA, CONDITIONED; FIBROBLASTS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; NEOPLASMS; PEPTIDOGLYCAN; RECEPTORS, CHEMOKINE; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 64049091130     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838660     Document Type: Article

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