Ginsenoside Rb1 protects cardiomyocytes against CoCl2-induced apoptosis in neonatal rats by inhibiting mitochondria permeability transition pore opening

Acta Pharmacologica Sinica

Volumn 31, Issue 6, 2010, Pages 687-695

  Kong, Hong Liang ^a   Li, Zhan Quan ^a   Zhao, Ying Jun ^a   Zhao, Shu Mei ^b   Zhu, Li ^b   Li, Tong ^a   Fu, Yao ^a   Li, Hui Jun ^a  

^a People's Hospital of Liaoning Province   (China)

^b SHENYANG NORMAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cardiomyocytes; Caspase 3; Cytochrome c; Ginsenoside Rb1; Glycogen synthase kinase 3 ; Hypoxia; Mitochondria permeability transition pore; Wortmannin

Indexed keywords

CALCEIN; CASPASE 3; COBALT CHLORIDE; CYTOCHROME C; GINSENOSIDE RB 1; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; VIDARABINE; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART PROTECTION; HYPOXIA; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANDROSTADIENES; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BLOTTING, WESTERN; CARDIOTONIC AGENTS; CASPASE 3; CELL HYPOXIA; CELLS, CULTURED; COBALT; CYTOCHROMES C; FLOW CYTOMETRY; GINSENOSIDES; GLYCOGEN SYNTHASE KINASE 3; IMMUNOHISTOCHEMISTRY; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCYTES, CARDIAC; PROTEIN KINASE INHIBITORS; RANDOM ALLOCATION; RATS;

EID: 77953272248     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.52     Document Type: Article

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