Development of a novel self-microemulsifying drug delivery system for reducing HIV protease inhibitor-induced intestinal epithelial barrier dysfunction

Molecular Pharmaceutics

Volumn 7, Issue 3, 2010, Pages 844-853

  Lei, Bokai ^a,b   Zha, Weibin ^a,c   Wang, Yun ^a,c   Wen, Cong ^b   Studer, Elaine J ^a   Wang, Xuan ^a   Jin, Fang ^b   Wang, Guangji ^c   Zhang, Luyong ^c   Zhou, Huiping ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antioxidants; ER stress; Inflammation; Ritonavir; SMEDDS

Indexed keywords

ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ASCORBIC ACID; CCAAT ENHANCER BINDING PROTEIN ALPHA; COSURFACTANT; DICHLORODIHYDROFLUORESCEIN DIACETATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GENERIC DRUG; INTERLEUKIN 6; LINOLEIC ACID ETHYL ESTER; OLEIC ACID; REACTIVE OXYGEN METABOLITE; RITONAVIR; SURFACTANT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG SOLUBILITY; DRUG STABILITY; DRUG TISSUE LEVEL; EMULSION; ENDOPLASMIC RETICULUM STRESS; ENTEROPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL SYMPTOM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; IN VIVO STUDY; INTESTINAL EPITHELIAL BARRIER DYSFUNCTION; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; MACROPHAGE; MALE; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; RAT; REPORTER GENE; SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM; WESTERN BLOTTING; ZETA POTENTIAL;

ALKALINE PHOSPHATASE; ANIMALS; ASCORBIC ACID; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV PROTEASE INHIBITORS; INTERLEUKIN-6; INTESTINAL MUCOSA; LINOLEIC ACIDS; MALE; MICE; MICE, INBRED C57BL; OLEIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RITONAVIR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77953244758     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100003r     Document Type: Article

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