An alternative to lung inflammation and fibrosis

American Journal of Pathology

Volumn 176, Issue 6, 2010, Pages 2595-2598

  Morris, Gilbert F ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P100;

CELL FUNCTION; CELL TYPE; COMPLEMENT ALTERNATIVE PATHWAY; CYTOKINE PRODUCTION; DISEASE COURSE; ENZYME ACTIVATION; IMMUNITY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LYMPHOCYTE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; ANIMAL; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; PNEUMONIA;

ANIMALS; HUMANS; LUNG; MICE; MICE, KNOCKOUT; NF-KAPPA B; NF-KAPPA B P52 SUBUNIT; PNEUMONIA; PULMONARY FIBROSIS;

EID: 77953213426     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.100272     Document Type: Note

References (24)

1. Vallabhapurapu S, Karin M: Regulation and function of NF-κB transcription factors in the immune system. Annu Rev Immunol 2009, 27:693-733
2. Yang L, Cui H, Wang Z, Zhang B, Ding J, Liu L, Ding H-F: Loss of negative feedback control of NF-κB2 activity in lymphocytes leads to fatal lung inflammation, Am J Pathol 2010, 176:2646-2657
3. Ghosh S, Hayden MS: New regulators of NF-κB in inflammation. Nat Rev Immunol 2008, 8:837-848
4. Mankan AK, Lawless MW, Gray SG, Kelleher D, McManus R: NF-κB regulation: the nuclear response. J Cell Mol Med 2009, 13:631-643
5. Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M: Activation by IKKα of a second, evolutionary conserved. NF-κB signaling pathway. Science 2001, 293:1495-1499
6. Fusco AJ, Savinova OV, Talwar R, Kearns JD, Hoffmann A, Ghosh G: Stabilization of RelB requires multidomain interactions with p100/p52. J Biol Chem 2008, 283:12324-12332
7. Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A: A fourth IκB protein within the NF-κB signaling module. Cell 2007, 128:369-381
8. Lawrence T, Gilroy DW, Colville-Nash PR, Willoughby DA: Possible new role for NF-κB in the resolution of inflammation. Nat Med 2001, 7:1291-1297
9. Pasparakis M: Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases. Nat Rev Immunol 2009, 9:778-788
10. Pasparakis M, Courtois G, Hafner M, Schmidt-Supprian M, Nenci A, Toksoy A, Krampert M, Goebeler M, Gillitzer R, Israel A, Krieg T, Rajewsky K, Haase I: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 2002, 417:861-866
11. Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M: Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 2007, 446:557-561
12. Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT: Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest 2007, 117:3909-3921
13. Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M: Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium, Proc Natl Acad Sci USA 2005, 102:17723-17728
14. Cheng DS, Han W, Chen SM, Sherrill TP, Chont M, Park GY, Sheller JR, Polosukhin VV, Christman JW, Yull FE, Blackwell TS: Airway epithelium controls lung inflammation and injury through the NF-κB pathway. J Immunol 2007, 178:6504-6513 (Pubitemid 46717434)
15. Saccani S, Pantano S, Natoli G: Modulation of NF-κB activity by exchange of dimers. Mol Cell 2003, 11:1563-1574
16. Stratis A, Pasparakis M, Rupec RA, Markur D, Hartmann K, Scharffetter-Kochanek K, Peters T, van Rooijen N, Krieg T, Haase I: Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation. J Clin Invest 2006, 116:2094-2104
17. Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR: Opposing functions of IKKβ during acute and chronic intestinal inflammation, Proc Natl Acad Sci USA 2008, 105:15058-15063
18. Tergaonkar V, Correa RG, Ikawa M, Verma IM: Distinct roles of IκB proteins in regulating constitutive NF-κB activity. Nat Cell Biol 2005, 7:921-923
19. Nakagome K, Okunishi K, Imamura M, Harada H, Matsumoto T, Tanaka R, Miyazaki J, Yamamoto K, Dohi M: IFN-γ attenuates antigen-induced overall immune response in the airway as a Th1-type immune regulatory cytokine. J Immunol 2009, 183:209-220
20. Lawrence T, Fong C: The resolution of inflammation: anti-inflammatory roles for NF-κB. Int J Biochem Cell Biol 42:519-523
21. Wynn TA: Cellular and molecular mechanisms of fibrosis. J Pathol 2008, 214:199-210
22. Billiau A, Matthys P: Interferon-γ: a historical perspective. Cytokine Growth Factor Rev 2009, 20:97-113
23. King TE Jr, Albera C, Bradford WZ, Costabel U, Hormel P, Lancaster L, Noble PW, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, du Bois RM: Effect of interferon γ-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial. Lancet 2009, 374:222-228
24. Morris GF, Brody AR: Molecular mechanisms of particle-induced lung disease. Edited by WN Rom. Philadelphia, Lippincott, Williams & Wilkins, 2007, pp 254-276