Proinflammatory cytokines are involved in the initiation of the abnormal matrix process in pseudoexfoliation syndrome/glaucoma

American Journal of Pathology

Volumn 176, Issue 6, 2010, Pages 2868-2879

  Zenkel, Matthias ^a   Lewczuk, Piotr ^a   Jünemann, Anselm ^a   Kruse, Friedrich E ^a   Naumann, Gottfried O H ^a   Schlötzer Schrehardt, Ursula ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; MESSENGER RNA; MUSCLE PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ANALYSIS; ANTERIOR EYE SEGMENT; AQUEOUS HUMOR; ARTICLE; CELL CULTURE; CILIARY BODY EPITHELIUM; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE DURATION; ELASTIC FIBER; EXTRACELLULAR MATRIX; EYE; FEMALE; GENE EXPRESSION; GLAUCOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; IRIS BLOOD VESSEL; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PSEUDOEXFOLIATION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANATOMY AND HISTOLOGY; ANIMAL; CELL LINE; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; OPEN ANGLE GLAUCOMA; PATHOLOGY; PATHOPHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; AQUEOUS HUMOR; CELL LINE; CYTOKINES; EXFOLIATION SYNDROME; EXTRACELLULAR MATRIX; EYE; FEMALE; GLAUCOMA, OPEN-ANGLE; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA;

EID: 77953208577     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.090914     Document Type: Article

References (47)

1. Schlötzer-Schrehardt U, Naumann GOH: Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol 2006, 141:921-937
2. Ritch R, Schlötzer-Schrehardt U: Exfoliation syndrome. Surv Ophthalmol 2001, 45:265-315
3. Ovodenko B, Rostagno A, Neubert TA, Shetty V, Thomas S, Yang A, Liebmann J, Ghiso J, Ritch R: Proteomic analysis of exfoliation deposits. Invest Ophthalmol Vis Sci 2007, 48:1447-1457
4. Zenkel M, Kruse FE, Jünemann AG, Naumann GOH, Schlötzer- Schrehardt U: Deficiency of the extracellular chaperone clusterin in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. Invest Ophthalmol Vis Sci 2006, 47:1982-1990
5. Schlötzer-Schrehardt U, Pasutto F, Sommer P, Hornstra I, Kruse FE, Naumann GO, Reis A, Zenkel M: Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients. Am J Pathol 2008, 173:1724-1735
6. Thorleifsson G, Magnusson KP, Sulem P, Walters GB, Gudbjartsson DF, Stefansson H, Jonsson T, Jonasdottir A, Jonasdottir A, Stefansdottir G, Masson G, Hardarson GA, Petursson H, Arnarsson A, Motallebipour M, Wallerman O, Wadelius C, Gulcher JR, Thorsteinsdottir U, Kong A, Jonasson F, Stefansson K: Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma. Science 2007, 317:1397-1400
7. Krumbiegel M, Pasutto F, Mardin CY, Weisschuh N, Paoli D, Gramer E, Zenkel M, Weber BH, Kruse FE, Schlötzer-Schrehardt U, Reis A: Exploring functional candidate genes for genetic association in German patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Invest Ophthalmol Vis Sci 2009, 50:2796-2801
8. Schlötzer-Schrehardt U, Zenkel M, Küchle M, Sakai LY, Naumann GOH: Role of transforming growth factor-β and its latent form binding protein in pseudoexfoliation syndrome. Exp Eye Res 2001, 73:765-780
9. Koliakos GG, Konstas AGP, Schlötzer-Schrehardt U, Hollo G, Katsimbris IE, Georgiadis N, Ritch R: 8-Isoprostaglandin F2A and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome. Br J Ophthalmol 2003, 87:353-356
10. Helbig H, Schlötzer-Schrehardt U, Noske W, Kellner U, Foerster MH, Naumann GOH: Anterior-chamber hypoxia and iris vasculopathy in pseudoexfoliation syndrome. German J Ophthalmol 1994, 3:148-153
11. Gonzalez P, Epstein DL, Borras T: Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure. Invest Ophthalmol Vis Sci 2000, 41:352-361 (Pubitemid 30080434)
12. Chen KH, Wu CC, Roy S, Lee SM, Liu JH: Increased interleukin-6 in aqueous humor of neovascular glaucoma. Invest Ophthalmol Vis Sci 1999, 40:2627-2632 (Pubitemid 29455493)
13. Wang N, Chintala SK, Fini ME, Schuman JS: Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat Med 2001, 7:304-309
14. Li G, Luna C, Liton PB, Navarro I, Epstein DL, Gonzalez P: Sustained stress response after oxidative stress in trabecular meshwork cells. Mol Vis 2007, 13:2282-2288
15. Liton PB, Gonzalez P: Stress response of the trabecular meshwork. J Glaucoma 2008, 17:378-385
16. Maggio M, Guralnik JM, Longo DL, Ferrucci L: Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol Biol Sci Med Sci 2006, 61A:575-584
17. Solis-Herruzo JA, de la Torre P, Diaz-Sanjuan T: IL-6 and extracellular matrix remodeling. Rev Esp Enferm Dig 2005, 97:575-595
18. Gauldie J, Kolb M, Sime PJ: A new direction in the pathogenesis of idiopathic pulmonary fibrosis. Respir Res 2002, 3:1-3
19. Nieto N: Oxidative stress and IL-6 mediate the fibrogenic effects of rodent Kupffer cells on stellate cells. Hepatology 2006, 44:1487-1501
20. Kantor TV, Friberg D, Medsger TA Jr, Buckingham RB, Whiteside TL: Cytokine production and serum levels in systemic sclerosis. Clin Immunol Immunopathol 1992, 65:278-285
21. Hasegawa M, Sato S, Fujimoto M, Ihn H, Kikuchi K, Takehara K: Serum levels of IL-6, oncostatin M, soluble IL-6 receptor, and soluble gp130 in patients with systemic sclerosis. J Rheumatol 1998, 25:308-313 (Pubitemid 28088260)
22. Tamm M, Bihl M, Eickelberg O, Stulz P, Perruchoud AP, Roth M: Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells. Am J Respir Cell Mol Biol 1998, 19:653-661 (Pubitemid 128354248)
23. Prince AM, Streeten BW, Ritch R: Preclinical diagnosis of pseudoexfoliation syndrome. Arch Ophthalmol 1987, 105:1076-1082
24. Schlötzer-Schrehardt U, Zenkel M, Nüsing RM: Expression and localization of FP and EP prostanoid receptor subtypes in human ocular tissues. Invest Ophthalmol Vis Sci 2002, 43:1475-1486
25. Martin-Vasallo P, Ghosh S, Coca-Prados M: Expression of Na, KATPase α subunit isoforms in the human ciliary body and cultured ciliary epithelial cells. J Cell Physiol 1989, 141:243-252 (Pubitemid 19272264)
26. Küchle M, Nguyen N, Hannappel E: The blood-aqueous barrier in eyes with pseudoexfoliation syndrome. Ophthalmic Res 1995, 27(Suppl 1):136-142
27. Hirano T, Matsuda T, Nakajima K: Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily. Stem Cells 1994, 12:262-277 (Pubitemid 2090109)
28. Chung HY, Sung B, Jung KJ, Zou Y, Yu BP: The molecular inflammatory process in aging. Antioxid Redox Signal 2006, 8:572-581
29. Banerjee S, Savant V, Scott RA, Curnow SJ, Wallace GR, Murray PI: Multiplex bead analysis of vitreous humor of patients with vitreoretinal disorders. Invest Ophthalmol Vis Sci 2007, 48:2203-2207
30. Curnow SJ, Falciani F, Durrani OM, Cheung CM, Ross EJ, Wloka K, Rauz S, Wallace GR, Salmon M, Murray PI: Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis. Invest Ophthalmol Vis Sci 2005, 46:4251-4259
31. van Kooij B, Rothova A, Rijkers GT, Groot-Mijnes JDF: Distinct cytokine and chemokine profiles in the aqueous of patients with uveitis and cystoid macular edema. Am J Ophthalmol 2006, 142:192-194
32. Wallace GR, Curnow SJ, Wloka K, Salmon M, Murray PI: The role of chemokines and their receptors in ocular disease. Prog Ret Eye Res 2004, 23:435-448
33. Huang P, Zhang SS, Zhang C: The two sides of cytokine signaling and glaucomatous optic neuropathy. J Ocul Biol Dis Inform 2009, 2:78-83
34. Liton PB, Luna C, Bodman M, Hong A, Epstein DL, Gonzalez P: Induction of IL-6 by mechanical stress in the trabecular meshwork. Biochem Biophys Res Commun 2005, 337:1229-1236
35. Sheppard D: Pulmonary fibrosis: a cellular overreaction or a failure of communication? J Clin Invest 2001, 107:1501-1502
36. Maruo N, Morita I, Shirao M, Murota S: IL-6 increases endothelial permeability in vitro. Endocrinology 1992, 131:710-714
37. Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, Mucke L: Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci USA 1993, 90:10061-10065
38. Hammer T, Schlötzer-Schrehardt U, Naumann GOH: Unilateral or asymmetric pseudoexfoliation syndrome? An ultrastructural study Arch Ophthalmol 2001, 119:1023-1031
39. Zenkel M, Kruse FE, Naumann GOH, Schlötzer-Schrehardt U: Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. Invest Ophthalmol Vis Sci 2007, 48:5558-5566
40. Liton PB, Li G, Luna C, Gonzalez P, Epstein DL: Cross-talk between TGF-β1 and IL-6 in human trabecular meshwork cells. Mol Vis 2009, 15:326-334
41. Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie: Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest 2001, 107:1529-1536
42. Duncan MR, Berman B: Stimulation of collagen and glycosaminoglycan production in cultured human adult dermal fibroblasts by recombinant human interleukin 6. J Invest Dermatol 1991, 97:686-692
43. Suhr KB, Tsuboi R, Seo EY, Piao YJ, Lee JH, Park JK, Ogawa H: Sphingosylphosphorylcholine stimulates cellular fibronectin expression through upregulation of IL-6 in cultured human dermal fibroblasts. Arch Dermatol Res 2003, 294:433-437 (Pubitemid 36241188)
44. Namba A, Aida Y, Suzuki N, Watanabe Y, Kawato T, Motohashi M, Maeno M, Matsumura H, Matsumoto M: Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes. Connect Tissue Res 2007, 48:263-270
45. Malecaze F, Simorre V, Chollet P, Tack JL, Muraine M, Le Guellec D, Vita N, Arne JL, Darbon JM: Interleukin-6 in tear fluid after photorefractive keratectomy and its effects on keratocytes in culture. Cornea 1997, 16:580-587 (Pubitemid 27381613)
46. Liechty KW, Adzick NS, Crombleholme TM: Diminished interleukin 6 (IL-6) production during scarless human fetal wound repair. Cytokine 2000, 12:671-676
47. Luckett-Chastain LR, Gallucci RM: Interleukin (IL)-6 modulates transforming growth factor-β expression in skin and dermal fibroblasts from IL-6-deficient mice. Br J Dermatol 2009, 161:237-248