Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 19, Issue 4, 1998, Pages 653-661

  Tamm, Michael ^a   Bihl, Michel ^a   Eickelberg, Oliver ^a   Stulz, Peter ^a   Perruchoud, André P ^a   Roth, Michael ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; THROMBOCYTE ACTIVATING FACTOR;

ARTICLE; CELL CULTURE; CELL DIVISION; CELL HYPOXIA; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; LUNG; METABOLISM; SECRETION; VASCULAR SMOOTH MUSCLE; VASCULARIZATION;

CELL DIVISION; CELL HYPOXIA; CELLS, CULTURED; FIBROBLASTS; GENE EXPRESSION; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; LUNG; MUSCLE, SMOOTH, VASCULAR; PLATELET ACTIVATING FACTOR; PLATELET-DERIVED GROWTH FACTOR; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0032185232     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.19.4.3058     Document Type: Article

References (35)

1. Kourembanas, S., and M. Bernfield. 1994. Hypoxia and endothelial-smooth muscle cell interactions in the lung. Am. J. Respir. Cell Mol. Biol. 1:373-374.
2. Schütte, H., J. Lohmeyer, S. Rosseau, S. Ziegler, C. Siebert, H. Kielisch, H. Pralle, F. Grimminger, H. Morr, and W. Seeger. 1996. Bronchoalveolar and systemic cytokine profiles in patients with ARDS, severe pneumonia and cardiogenic pulmonary oedema. Eur. Respir. J. 9:1858-1867.
3. Dawes, K. A., A. J. Peacock, A. J. Gray, J. E. Bishop, and G. J. Laurent. 1994. Characterisation of fibroblast mitogens and chemoattractants produced by endothelial cells exposed to hypoxia. Am. J. Respir. Cell Mol. Biol. 10:552-559.
4. Kuwabara, K., S. Ogawa, M. Matsumoto, S. Koga, M. Clauss, D. J. Pinsky, P. Lyn, J. Leavy, L. Witte, J. Joseph-Silverstone, M. B. Furie, G. Torcia, F. Cozzolino, T. Kamada, and D. M. Stern. 1995. Hypoxia-mediated induction of acidic-basic fibroblast growth factor and platelet derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc. Natl. Acad. Sci. USA 92:4606-4610.
5. Arnould, T., C. Michiels, and J. Remacle. 1993. Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD 18/CD11B, and ICAM. Am. J. Physiol. 264:C1102-C1110.
6. Caplan, M. S., L. Adler, A. Kelly, and W. Hsuch. 1992. Hypoxia increases stimulus induced PAF production and release from human umbilici vein endothelial cells. Biochim. Biophys. Acta 1128:205-210.
7. Hemple, S. L., M. M. Monick, and G. W. Hunninghake. 1996. Effect of hypoxia on release of IL-1 and TNF by human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 14:170-176.
8. Roth, M., M. Nauck, M. Tamm, A. P. Perruchoud, R. Ziesche, and L. H. Block. 1995. Intracellular interleukin-6 mediates platelet-derived growth factor-induced proliferation of nontransformed cells. Proc. Natl. Acad. Sci. USA 92:1312-1316.
9. Roth, M., M. Nauck, S. Yousefi, M. Tamm, K. Blaser, A. P. Perruchoud, and H.-U. Simon. 1996. Platelet-activating factor exerts mitogenic activity and stimulates expression of interleukin-6 and interleukin-8 in human lung fibroblasts via binding to its functional receptor. J. Exp. Med. 184:191-201.
10. Maeda, Y., M. Matsumoto, O. Hori, K. Kuwabara, S. Ogawa, S. D. Yan, T. Ohtsuki, T. Kinoshita, T. Kamada, and D. Stern. 1994. Hypoxia/reoxygenation-mediated induction of astrocytes interleukin-6: a paracrine mechanism potentially enhancing neurone survival. J. Exp. Med. 180:2297-2308.
11. Thivierge, M., and M. Rola-Pleszczynski. 1992. Platelet activating factor enhances interleukin-6 production by alveolar macrophages. J. Allergy Clin. Immunol. 90:796-802.
12. Karakurum, M., R. Shreeniwas, J. Chen, D. Pinsky, S. D. Yan, M. Anderson, K. Sunouchi, J. Major, T. Hamilton, K. Kuwabara, A. Rot, R. Nowygrod, and D. Stern. 1994. Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J. Clin. Invest. 93:1564-1570.
13. Humbert, M., G. Monti, F. Brenot, O. Sitbon, A. Portier, L. Grangeot-Keros, P. Duroux, P. Galanaud, G. Simonneau, and D. Emilie. 1995. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am. J. Respir. Crit. Care Med. 151:1628-1631
14. Voelkel, N. F., and R. M. Tuder. 1995. Cellular and molecular mechanisms in the pathogenesis of severe pulmonary hypertension. Eur. Respir. J. 8: 2129-2138.
15. Roth, M., L. R. Emmons, A. P. Perruchoud, and L. H. Block. 1991. Expression of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes are stimulated by recombinant platelet-derived growth factor isoforms. Proc. Natl. Acad. Sci. USA 88:1888-1892.
16. Roth, M., M. Solêr, M. Hornung, L. R. Emmons, P. Stulz, and A. P. Perruchoud. 1992. Cell cultures from cryopreserved human lung tissue. Tissue Cell 24:455-457.
17. Nauck, M., M. Roth, M. Tamm, O. Eickelberg, H. Wieland, and A. P. Perruchoud. 1997. Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is down-regulated by corticosteroids. Am. J. Respir. Mol. Cell Biol. 16:398-406.
18. Lindl, T., and J. Bauer, editors. 1989. Zell-und Gewebekultur. Gustav Fischer Verlag, Stuttgart, New York, 179-181.
19. Roth, M., R. Keul, L. R. Emmons, W. H. Hörl, and L. H. Block. 1992. Manidipine regulates the transcription of cytokine genes. Proc. Natl. Acad. Sci. USA 89:4071-1075.
20. Phillips, P. G., L. M. Birnby, and A. Narendra. 1995. Hypoxia induces capillary network formation in cultured bovine pulmonary microvessel endothelial cells. Am. J. Physiol. 268:L789-L800.
21. Kelly, J. 1990. Cytokines of the lung. Am. Rev. Respir. Dis. 141:765-788.
22. Rolfe, M. W., S. L. Kunkel, T. J. Standiford, S. W. Chensue, R. M. Allen, H. L. Evanoff, S. H. Phan, and R. M. Strieter. 1991. Pulmonary fibroblast expression of interleukin-8: a model for alveolar macrophage-derived cytokine networking. Am. J. Respir. Cell Mol. Biol. 5:493-501.
23. Kneussl, M. P., I. M. Land, and F. P. Brenot. 1996. Medical management of primary pulmonary hypertension. Eur. Respir. J. 9:2401-2409.
24. Marinelli, W. A., V. A. Polunovsky, K. R. Harmon, and P. B. Bitterman. 1991. Role of platelet-derived growth factor in pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 5:503-504.
25. Walsh, J., M. Absher, and J. Kelley. 1993. Variable expression of platelet-derived growth factor family proteins in acute lung injury. Am. J. Respir. Cell Mol. Biol. 9:637-644.
26. Osornio-Vargas, A. R., A. L. Goodell, N. A. Hernandez-Rodrigues, A. R. Brody, P. G. Coin, A. Badget, and J. C. Bonner. 1995. Platelet-derived growth factor (PDGF)-AA, -AB, and -BB induced differential chemotaxis of early passage rat lung fibroblasts. Am. J. Respir. Cell Mol. Biol. 12:33-40.
27. Bonner, J. C., A. R. Osornio-Vargas, A. Badgett, and A. R. Brody. 1991. Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor-AA, -AB, and -BB isoforms secreted by rat alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 5:539-547.
28. Vignaud, J. M., M. Allan, N. Martinet, M. Pech, F. Plenat, and Y. Martinet. 1991. Presence of platelet-derived growth factor in normal and fibrotic lung is specifically associated with interstitial macrophages, while both interstitial macrophages and alveolar epithelial cells exert the c-sis protooncogene. Am. J. Respir. Cell Mol. Biol. 5:531-538.
29. Chen, C. R., N. F. Voelkel, and S. G. Chang. 1992. Pulmonary vascular reactivity: effect of PAF and PAF antagonists. J. Appl. Physiol. 73:1762-1769.
30. Braquet, P., B. Pignol, T. Maisonnet, and J. M. Mencia-Huerta. 1991. Platelet-activating factor modulates interleukin-6 production by mouse fibroblasts. Int. Arch. Allergy Appl. Immunol. 94:165-166.
31. Thivierge, M., and M. Rola-Pleszczysnki. 1992. Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. J. Allergy Clin. Immunol. 90:796-802.
32. Au, B. T., T. J. Williams, and P. D. Collins. 1994. Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator. J. Immunol. 152:5411-5419.
33. Lu, C., and R. S. Kerbel. 1993. Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression. J. Cell Biol. 120:1281-1288.
34. Cohen, T., D. Nahari, L. W. Cerem, G. Neufeld, and B. Z. Levi. 1996. Interleukin-6 induces the expression of vascular endothelial growth factor. J. Biol. Chem. 271:736-741.
35. Shweiki, D., A. Itin, D. Soffer, and E. Keshet. 1992. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia initiated angiogenesis. Nature 359:843-845.