Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes

Connective Tissue Research

Volumn 48, Issue 5, 2007, Pages 263-270

  Namba, Aki ^a   Aida, Yukiko ^a   Suzuki, Naoto ^a   Watanabe, Yusuke ^a   Kawato, Takayuki ^a   Motohashi, Masafumi ^a   Maeno, Masao ^a   Matsumura, Hideo ^a   Matsumoto, Mitsuhiko ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

BMP 7; Cartilage matrix proteins; Human chondrocytes; IL 6; Soluble IL 6 receptor

Indexed keywords

AGGRECAN; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN RECEPTOR; COLLAGEN TYPE 2; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LINK PROTEIN; MATRIX PROTEIN; OSTEOGENIC PROTEIN 1; TRANSCRIPTION FACTOR SOX9;

ARTICLE; CARTILAGE CELL; CARTILAGE MATRIX; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TISSUE REPAIR;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN RECEPTORS; BONE MORPHOGENETIC PROTEINS; CELL LINE; CELL PROLIFERATION; CHONDROCYTES; EXTRACELLULAR MATRIX PROTEINS; HIGH MOBILITY GROUP PROTEINS; HUMANS; INTERLEUKIN-6; RECEPTORS, INTERLEUKIN-6; TRANSCRIPTION FACTORS;

EID: 34648813841     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.1080/03008200701587513     Document Type: Article

References (22)

1. Foged, J. (1949) Temporomandibular arthrosis. Lancet, 257, pp. 1209-1211.
2. Frenkel, S. R. and Cesare, P. E. Di (1999) Degradation and repair of articular cartilage. Front. Biosci., 4, pp. d671-d685.
3. Poole, A. R. (1999) An introduction to the pathophysiology of osteoarthritis. Front. Biosci., 4, pp. d662-d670.
4. De Benedetti, F., Robbioni, P., Massa, M., Viola, S., Albani, S. and Martini, A. (1992) Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis. Clin. Exp. Rheumatol., 10, pp. 493-498.
5. Fu, K., Ma, X., Zhang, Z., Pang, X. and Chen, W. (1995) Interleukin-6 in synovial fluid and HLA-DR expression in synovium from patients with temporomandibular disorders. J. Orofac. Pain., 9, pp. 131-137.
6. Sandler, N. A., Buckley, M. J., Cillo, J. E. and Brain, T. W. (1998) Correlation of inflammatory cytokines with arthroscopic findings in patients with temporomandibular joint internal derangements. J. Oral Maxillofac. Surg., 56, pp. 534-543.
7. Kishimoto, T., Akira, S., Narazaki, M. and Taga, T. (1995) Interleukin-6 family of cytokines and gp130. Blood, 86, pp. 1243-1254.
8. De Benedetti, F., Massa, M., Pignatti, P., Albani, S., Novick, D. and Martini, A. (1994) Serum soluble interleukin 6 (IL-6) receptor and IL-6/ soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. J. Clin. Invest., 93, pp. 2114-2119.
9. Kotake, S., Sato, K., Takahashi, N., Udagawa, N., Nakamura, I., Yamaguchi, A., Kishimoto, T., Suda, T. and Kashiwazaki, T. (1996) Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J. Bone Miner. Res., 11, pp. 88-95.
10. Flannery, C. R., Little, C. B., Hughes, C. E., Curtis, C. L., Caterson, B. and Jones, S. A. (2000) IL-6 and its soluble receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. Matrix Biol., 19, pp. 549-553.
11. Legendre, F., Dudhia, J., Pujol, J. P. and Bogdanowicz, P. (2003) JAK/ STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression. J. Biol. Chem., 278, pp. 2903-2912.
12. Aida, Y., Maeno, M., Ito-Kato, E., Suzuki, N., Shiratsuchi, H. and Matsumura, H. (2004) Effect of IL-1α on the expression of cartilage matrix proteins in human chondrosarcoma cell line OUMS-27. Life Sci, 75, pp. 3173-3184.
13. Aida, Y., Maeno, M., Suzuki, N., Shiratsuchi, H., Motohashi, M. and Matsumura, H. (2005) The effect of IL-1β on the expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in human chondrocytes. Life Sci., 77, pp. 3210-3221.
14. Aida, Y., Maeno, M., Suzuki, N., Namba, A., Motohashi, M., Matsumoto, M., Makimura, M. and Matsumura, H. (2006) The effect of IL-1β on the expression of inflammatory cytokines and their receptors in human chondrocytes. Life Sci., 79, pp. 764-771.
15. Silacci, P., Dayer, J. M., Desgeorges, A., Peter, R., Manueddu, C. and Guerne, P. A. (1998) Interleukin (IL)-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity. J. Biol. Chem., 273, pp. 13625-13629.
16. Dijkgraaf, L. C., de Bont, L. G., Boering, G. and Liem, R. S. (1995) Normal cartilage structure, biochemistry, and metabolism: A review of the literature. J. Oral Maxillofac. Surg., 53, pp. 924-929.
17. Ijima, Y., Kobayashi, M. and Kubota, E. (2001) Role of interleukin-1 induction of matrix metalloproteinases synthesized by rat temporomandibular joint chondrocytes and disc cells. Eur. J. Oral Sci., 109, pp. 50-59.
18. Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L. and Karsenty, G. (1997) Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell, 89, pp. 747-754.
19. Muir, H. (1995) The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules. Bioessays, 17, pp. 1039-1048.
20. Hardingham, T. E. and Fosang, A. J. (1992) Proteoglycans: Many forms and many functions. FASEB J., 6, pp. 861-870.
21. Poole, A. R., Pidoux, I., Reiner, A. and Rosenberg, L. (1982) An immunoelectron microscope study of the organization of proteoglycan monomer, link protein, and collagen in the matrix of articular cartilage. J. Cell Biol., 93, pp. 921-937.
22. Flechtenmacher, J., Huch, K., Thonar, E. J., Mollenhauver, J. A., Davis, S. R., Schmid, T. M., Puhl, W., Sampath, T. K., Aydelotte, M. B. and Kuettner, K. E. (1996) Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes. Arthritis Rheum., 39, pp. 1896-1904.