Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1β-stimulated human chondrocytes

British Journal of Pharmacology

Volumn 160, Issue 5, 2010, Pages 1252-1262

  Joos, H ^a   Albrecht, W ^b   Laufer, S ^c   Brenner, R E ^a  

^a UNIVERSITY OF ULM   (Germany)

^b C a i r Biosciences GmbH   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Birb 796; Chondrocytes; In vitro model; Interleukin 1 ; Osteoarthritis; P38MAPK inhibition; Pamapimod; SB203580; Whole genome array

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CBS 3868; COLLAGENASE 3; CYCLOOXYGENASE 2; CYTOKINE RECEPTOR; DORAMAPIMOD; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NITRIC OXIDE; OSTEOPROTEGERIN; PAMAPIMOD; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PYRIDO[ 2,3 D]PYRIMIDIN 7 (8H) ONE; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY 11B; UNCLASSIFIED DRUG; [ 4[ 6( 4 FLUOROPHENYL)1 OXO 2,3 DIHYDRO 1H 1 LAMBDA 4 IMIDAZO[ 2,1 B]THIAZOL 5 YL]PYRIDIN 2 YL] 1 PHENYLETHYLAMINE; AUTACOID; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE INHIBITOR;

ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATION; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; ANTAGONISTS AND INHIBITORS; CULTURE TECHNIQUE; DNA MICROARRAY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; PROCEDURES;

CELL CULTURE TECHNIQUES; CHONDROCYTES; DINOPROSTONE; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; NITRIC OXIDE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS;

EID: 77953205672     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00760.x     Document Type: Article

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