Differential decline in behavioral performance of Drosophila melanogaster with age

Mechanisms of Ageing and Development

Volumn 127, Issue 7, 2006, Pages 647-651

  Simon, Anne F ^a   Liang, Debbie T ^b   Krantz, David E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Drosophila; Electric shock; Flight; Geotaxis; Locomotion; Olfactory learning; Phototaxis

Indexed keywords

ECDYSONE RECEPTOR;

AGING; ALLELE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DETERIORATION; DROSOPHILA MELANOGASTER; ESCAPE BEHAVIOR; EXPLORATORY BEHAVIOR; FEMALE; GENETIC DIFFERENCE; GEOTROPISM; GRAVITY; LEARNING; LOCOMOTION; MALE; MEMORY; MOVEMENT (PHYSIOLOGY); NONHUMAN; PHOTOTAXIS; PRIORITY JOURNAL; WILD TYPE;

AGING; ANIMALS; BEHAVIOR, ANIMAL; DROSOPHILA MELANOGASTER; LEARNING; LOCOMOTION;

DROSOPHILA MELANOGASTER;

EID: 33747387670     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2006.02.006     Document Type: Article

References (26)

1. Arking R. Biology of Aging: Observation and Principles (1998), Mass, Sunderland
2. Arking R., and Wells R.A. Genetic alteration of normal aging processes is responsible for extended longevity in Drosophila. Dev. Genet. 11 (1990) 141-148
3. Benzer S. Behavioral mutants of Drosophila melanogaster isolated by countercurrent distribution. PNAS 58 (1967) 1112-1119
4. Benzer S. Genetic dissection of behavior. Sci. Am. 229 (1973) 24-37
5. Connolly J.B., and Tully T. Behavior, learning, and memory. In: Roberts D.B. (Ed). Drosophila: A Practical Approach (1998), Oxford
6. Cook-Wiens E., and Grotewiel M.S. Dissociation between functional senescence and oxidative stress resistance in Drosophila. Exp. Gerontol. 37 (2002) 1347-1357
7. Driver C. The Gompertz function does not measure ageing. Biogerontology 2 (2001) 61-65
8. Driver C. A further comment on why the Gompertz plot does not measure aging. Biogerontology 4 (2003) 325-327
9. Fernandez J.R., Grant M.D., Tulli N.M., Karkowski L.M., and McClearn G.E. Differences in locomotor activity across the lifespan of Drosophila melanogaster. Exp. Gerontol. 34 (1999) 621-631
10. Finch C.E., and Ruvkun G. The genetics of aging. Annu. Rev. Genom. Human Genet. 2 (2001) 435-462
11. Gargano J.W., Martin I., Bhandari P., and Grotewiel M.S. Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila. Exp. Gerontol. 40 (2005) 386
12. Goddeeris M.M., Cook-Wiens E., Horton W.J., Wolf H., Stoltzfus J.R., Borrusch M., and Grotewiel M.S. Delayed behavioural aging and altered mortality in Drosophila beta integrin mutants. Aging Cell 2 (2003) 257-264
13. Grotewiel M.S., Martin I., Bhandari P., and Cook-Wiens E. Functional senescence in Drosophila melanogaster. Ageing Res. Rev. 4 (2005) 372
14. Ingram D.K. Age-related decline in physical activity: generalization to nonhumans. Med. Sci. Sports Exer. 32 (2000) 1623-1629
15. Le Bourg, E., 1988. Non-sexual behavior. In: Lints, F.A., Soliman, M.H. (Eds.), Drosophila as a Model Organism for Ageing Studies. London.
16. Le Bourg E. Effects of aging on learned suppression of photopositive tendencies in Drosophila melanogaster. Neurobiol. Aging 25 (2004) 1241-1252
17. Leffelaar D., and Grigliatti T.A. Age-dependent behavior loss in adult Drosophila melanogaster. Dev. Genet. 4 (1984) 211-227
18. Minois N., Khazaeli A.A., and Curtsinger J.W. Locomotor activity as a function of age and life span in Drosophila melanogaster overexpressing hsp 70. Exp. Gerontol. 36 (2001) 1137-1153
19. Partridge L., and Gems D. Mechanisms of ageing: public or private?. Nat. Rev. Genet. 3 (2002) 165-175
20. Paternostro G., Vignola C., Bartsch D.-U., Omens J.H., McCulloch A.D., and Reed J.C. Age-associated cardiac dysfunction in Drosophila melanogaster. Circ. Res. 88 (2001) 1053-1058
21. Promislow D.E.L., and Tatar M. Mutation and senescence: where genetics and demography meet. Genetica 102/103 (1998) 299
22. Simon A.F., Shih C., Mack A., and Benzer S. Steroid control of longevity in Drosophila melanogaster. Science 299 (2003) 1407-1410
23. Tatar M., Kopelman A., Epstein D., Tu M.P., Yin C.M., and Garofalo R.S. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292 (2001) 107-110
24. Tower J. Transgenic methods for increasing Drosophila life span. Mech. Ageing Dev. 118 (2000) 1-14
25. Wessells R.J., Fitzgerald E., Cypser J.R., Tatar M., and Bodmer R. Insulin regulation of heart function in aging fruit flies. Nat. Genet. 36 (2004) 1275-1281
26. Yeoman M.S., and Faragher R.G.A. Ageing and the nervous system: insights from studies on invertebrates. Biogerontology 2 (2001) 85-97