Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current

British Journal of Pharmacology

Volumn 160, Issue 5, 2010, Pages 1072-1082

  Weiss, S ^a,c   Benoist, D ^d   White, E ^d   Teng, W ^e   Saint, D A ^b,c  

^a Biology and Environment   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c NeoViva Pty Ltd   (Australia)

^d UNIVERSITY OF LEEDS   (United Kingdom)

^e WUHAN UNIVERSITY   (China)

Author keywords

Cardioprotection; Ischaemia; Persistent sodium current (INaP); Reperfusion; Riluzole

Indexed keywords

CALCIUM ION; RILUZOLE; SODIUM ION; CALCIUM; SODIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CALCIUM CELL LEVEL; CELL HYPOXIA; CONTROLLED STUDY; DRUG MECHANISM; HEART CONTRACTION; HEART INDEX; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PERFUSION; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; REOXYGENATION; REPERFUSION INJURY; SODIUM CURRENT; ACTION POTENTIAL; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; ELECTROCARDIOGRAPHY; HEART; HEART LEFT VENTRICLE FUNCTION; MEMBRANE POTENTIAL; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREVENTION AND CONTROL; SPRAGUE DAWLEY RAT; SWINE; WISTAR RAT;

ACTION POTENTIALS; ANIMALS; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART; MALE; MEMBRANE POTENTIALS; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RILUZOLE; SODIUM CHANNELS; SWINE; VENTRICULAR DYSFUNCTION, LEFT;

EID: 77953196524     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00766.x     Document Type: Article

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