3-(R)-[3-2-methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1, 5-benzoxathiepine bromhydrate (F 15845) prevents ischemia-induced heart remodeling by reduction of the intracellular Na+ overload

Journal of Pharmacology and Experimental Therapeutics

Volumn 330, Issue 3, 2009, Pages 696-703

  Vié, Bruno ^a   Sablayrolles, Sylvie ^a   Létienne, Robert ^a   Vacher, Bernard ^a   Darmellah, Amaria ^b   Bernard, Monique ^c   Feuvray, Danielle ^b   Le Grand, Bruno ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 (2 METHOXYPHENYLTHIO) 2 METHYLPROPYL]AMINO 3,4 DIHYDRO 2H 1,5 BENZOXATHIEPINE BROMHYDRATE; ATENOLOL; CARIPORIDE; CEVADINE; DILTIAZEM; F 15845; LIDOCAINE; SODIUM 23; SODIUM CHANNEL BLOCKING AGENT; TROPONIN I; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLE; GUINEA PIG; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; IC 50; IN VITRO STUDY; ISOLATED HEART; MALE; MOUSE STRAIN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; REPERFUSION; SALT LOADING; SODIUM CELL LEVEL;

ANIMALS; BENZOTHIEPINS; DIABETES MELLITUS, EXPERIMENTAL; GUINEA PIGS; LYSOPHOSPHATIDYLCHOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM RADIOISOTOPES; VENTRICULAR REMODELING; VERATRINE;

EID: 70349125922     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.153122     Document Type: Article

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