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Volumn 6, Issue 5, 2010, Pages 31-

A MATE-family efflux pump rescues the Escherichia coli 8-oxoguanine-repair-deficient mutator phenotype and protects against H2O2 killing

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; 8-HYDROXYGUANINE; ANTIPORTER; BACTERIAL DNA; BACTERIAL PROTEIN; DNA GLYCOSYLTRANSFERASE; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; GENOMIC DNA; GUANINE; HYDROGEN PEROXIDE; MDTK PROTEIN, E COLI; MUTATION AND TOXIN EXTRUSION PROTEIN; NUCLEOTIDE; PHARMACOLOGY; PROTEIN NORM; REACTIVE OXYGEN METABOLITE; SODIUM PEROXIDE; UNCLASSIFIED DRUG;

EID: 77953179574     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000931     Document Type: Article
Times cited : (31)

References (55)
  • 1
    • 0029943449 scopus 로고    scopus 로고
    • Mismatch repair in replication fidelity, genetic recombination, and cancer biology
    • Modrich P, Lahue R (1996) Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem 65: 101-133.
    • (1996) Annu Rev Biochem , vol.65 , pp. 101-133
    • Modrich, P.1    Lahue, R.2
  • 3
    • 0026701365 scopus 로고
    • The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)
    • Michaels ML, Miller JH (1992) The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine). J Bacteriol 174: 6321-6325.
    • (1992) J Bacteriol , vol.174 , pp. 6321-6325
    • Michaels, M.L.1    Miller, J.H.2
  • 4
    • 0026452281 scopus 로고
    • Genetic effects of oxidative DNA damage: Comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coli
    • Wood ML, Esteve A, Morningstar ML, Kuziemko GM, Essigmann JM (1992) Genetic effects of oxidative DNA damage: comparative mutagenesis of 7,8- dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coli. Nucleic Acids Res 20: 6023-6032.
    • (1992) Nucleic Acids Res , vol.20 , pp. 6023-6032
    • Wood, M.L.1    Esteve, A.2    Morningstar, M.L.3    Kuziemko, G.M.4    Essigmann, J.M.5
  • 5
    • 0026592966 scopus 로고
    • 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions
    • Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA (1992) 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions. J Biol Chem 267: 166-172.
    • (1992) J Biol Chem , vol.267 , pp. 166-172
    • Cheng, K.C.1    Cahill, D.S.2    Kasai, H.3    Nishimura, S.4    Loeb, L.A.5
  • 6
    • 0019382868 scopus 로고
    • Incidence of mutator strains in Escherichia coli and coliforms in nature
    • Gross MD, Siegel EC (1981) Incidence of mutator strains in Escherichia coli and coliforms in nature. Mutat Res 91: 107-110.
    • (1981) Mutat Res , vol.91 , pp. 107-110
    • Gross, M.D.1    Siegel, E.C.2
  • 7
    • 0029860724 scopus 로고    scopus 로고
    • High mutation frequencies among Escherichia coli and Salmonella pathogens
    • LeClerc JE, Li B, Payne WL, Cebula TA (1996) High mutation frequencies among Escherichia coli and Salmonella pathogens. Science 274: 1208-1211.
    • (1996) Science , vol.274 , pp. 1208-1211
    • Leclerc, J.E.1    Li, B.2    Payne, W.L.3    Cebula, T.A.4
  • 8
    • 0030777211 scopus 로고    scopus 로고
    • Highly variable mutation rates in commensal and pathogenic Escherichia coli
    • Matic I, Radman M, Taddei F, Picard B, Doit C, et al. (1997) Highly variable mutation rates in commensal and pathogenic Escherichia coli. Science 277: 1833 1834.
    • (1997) Science , vol.277 , pp. 1833-1834
    • Matic, I.1    Radman, M.2    Taddei, F.3    Picard, B.4    Doit, C.5
  • 9
    • 0034685940 scopus 로고    scopus 로고
    • High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection
    • Oliver A, Canton R, Campo P, Baquero F, Blazquez J (2000) High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science 288: 1251-1254.
    • (2000) Science , vol.288 , pp. 1251-1254
    • Oliver, A.1    Canton, R.2    Campo, P.3    Baquero, F.4    Blazquez, J.5
  • 10
    • 67049096137 scopus 로고    scopus 로고
    • Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system
    • Mandsberg LF, Ciofu O, Kirkby N, Christiansen LE, Poulsen HE, et al. (2009) Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system. Antimicrob Agents Chemother 53: 2483-2491.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2483-2491
    • Mandsberg, L.F.1    Ciofu, O.2    Kirkby, N.3    Christiansen, L.E.4    Poulsen, H.E.5
  • 11
    • 0014945242 scopus 로고
    • Fitness of an Escherichia coli mutator gene
    • Gibson TC, Scheppe ML, Cox EC (1970) Fitness of an Escherichia coli mutator gene. Science 169: 686-688.
    • (1970) Science , vol.169 , pp. 686-688
    • Gibson, T.C.1    Scheppe, M.L.2    Cox, E.C.3
  • 12
    • 0016188276 scopus 로고
    • Selection for high mutation rates in chemostats
    • Cox EC, Gibson TC (1974) Selection for high mutation rates in chemostats. Genetics 77: 169-184.
    • (1974) Genetics , vol.77 , pp. 169-184
    • Cox, E.C.1    Gibson, T.C.2
  • 13
    • 0021032993 scopus 로고
    • Competition between high and low mutating strains of Escherichia coli
    • Chao L, Cox EC (1983) Competition between high and low mutating strains of Escherichia coli. Evolution 37: 125-134.
    • (1983) Evolution , vol.37 , pp. 125-134
    • Chao, L.1    Cox, E.C.2
  • 14
    • 85083132425 scopus 로고
    • The evolution of mutation rates
    • Kimura M (1967) The evolution of mutation rates. Genetics 73: 1-18.
    • (1967) Genetics , vol.73 , pp. 1-18
    • Kimura, M.1
  • 15
    • 0015787984 scopus 로고
    • The evolution of mutation rates
    • Leigh EG, Jr. (1973) The evolution of mutation rates. Genetics 73: Suppl 73: 71-18.
    • (1973) Genetics , vol.73 , Issue.SUPPL. 73 , pp. 71-118
    • Leigh Jr., E.G.1
  • 16
    • 0030032923 scopus 로고    scopus 로고
    • Muller's ratchet decreases fitness of a DNAbased microbe
    • Andersson DI, Hughes D (1996) Muller's ratchet decreases fitness of a DNAbased microbe. Proc Natl Acad Sci U S A 93: 906-907.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 906-907
    • Andersson, D.I.1    Hughes, D.2
  • 17
    • 0029931416 scopus 로고    scopus 로고
    • Estimate of the genomic mutation rate deleterious to overall fitness in
    • Kibota TT, Lynch M (1996) Estimate of the genomic mutation rate deleterious to overall fitness in E. coli. Nature 381: 694-696.
    • (1996) E. Coli. Nature , vol.381 , pp. 694-696
    • Kibota, T.T.1    Lynch, M.2
  • 18
    • 0034049514 scopus 로고    scopus 로고
    • The consequences of growth of a mutator strain of Escherichia coli as measured by loss of function among multiple gene targets and loss of fitness
    • Funchain P, Yeung A, Stewart JL, Lin R, Slupska MM, et al. (2000) The consequences of growth of a mutator strain of Escherichia coli as measured by loss of function among multiple gene targets and loss of fitness. Genetics 154: 959-970.
    • (2000) Genetics , vol.154 , pp. 959-970
    • Funchain, P.1    Yeung, A.2    Stewart, J.L.3    Lin, R.4    Slupska, M.M.5
  • 19
    • 0021749518 scopus 로고
    • Selection against hypermutability in Escherichia coli during long term evolution
    • Trobner W, Piechocki R (1984) Selection against hypermutability in Escherichia coli during long term evolution. Mol Gen Genet 198: 177-178.
    • (1984) Mol Gen Genet , vol.198 , pp. 177-178
    • Trobner, W.1    Piechocki, R.2
  • 20
    • 0023107797 scopus 로고
    • Cloning of genes from members of the family Enterobacteriaceae with mini-Mu bacteriophage containing plasmid replicons
    • Groisman EA, Casadaban MJ (1987) Cloning of genes from members of the family Enterobacteriaceae with mini-Mu bacteriophage containing plasmid replicons. J Bacteriol 169: 687-693.
    • (1987) J Bacteriol , vol.169 , pp. 687-693
    • Groisman, E.A.1    Casadaban, M.J.2
  • 21
    • 0032949426 scopus 로고    scopus 로고
    • The multidrug efflux protein NorM is a prototype of a new family of transporters
    • Brown MH, Paulsen IT, Skurray RA (1999) The multidrug efflux protein NorM is a prototype of a new family of transporters. Mol Microbiol 31: 394-395.
    • (1999) Mol Microbiol , vol.31 , pp. 394-395
    • Brown, M.H.1    Paulsen, I.T.2    Skurray, R.A.3
  • 23
    • 0037337313 scopus 로고    scopus 로고
    • The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
    • Hvorup RN, Winnen B, Chang AB, Jiang Y, Zhou XF, et al. (2003) The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily. Eur J Biochem 270: 799-813.
    • (2003) Eur J Biochem , vol.270 , pp. 799-813
    • Hvorup, R.N.1    Winnen, B.2    Chang, A.B.3    Jiang, Y.4    Zhou, X.F.5
  • 24
    • 50949102768 scopus 로고    scopus 로고
    • Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli
    • Long F, Rouquette-Loughlin C, Shafer WM, Yu EW (2008) Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob Agents Chemother 52: 3052-3060.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3052-3060
    • Long, F.1    Rouquette-Loughlin, C.2    Shafer, W.M.3    Yu, E.W.4
  • 25
    • 0031836031 scopus 로고    scopus 로고
    • NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli
    • Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, et al. (1998) NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrob Agents Chemother 42: 1778-1782.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 1778-1782
    • Morita, Y.1    Kodama, K.2    Shiota, S.3    Mine, T.4    Kataoka, A.5
  • 26
    • 33646568438 scopus 로고    scopus 로고
    • Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): Unique resources for biological research
    • Kitagawa M, Ara T, Arifuzzaman M, Ioka-Nakamichi T, Inamoto E, et al. (2005) Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research. DNA Res 12: 291-299.
    • (2005) DNA Res , vol.12 , pp. 291-299
    • Kitagawa, M.1    Ara, T.2    Arifuzzaman, M.3    Ioka-Nakamichi, T.4    Inamoto, E.5
  • 27
    • 35148899681 scopus 로고    scopus 로고
    • Stress-induced mutagenesis in bacteria
    • Foster PL (2007) Stress-induced mutagenesis in bacteria. Crit Rev Biochem Mol Biol 42: 373-397.
    • (2007) Crit Rev Biochem Mol Biol , vol.42 , pp. 373-397
    • Foster, P.L.1
  • 28
    • 58449112244 scopus 로고    scopus 로고
    • Spontaneous mutagenesis is elevated in protease-defective cells
    • Al Mamun AA, Humayun MZ (2009) Spontaneous mutagenesis is elevated in protease-defective cells. Mol Microbiol 71: 629-639.
    • (2009) Mol Microbiol , vol.71 , pp. 629-639
    • Al Mamun, A.A.1    Humayun, M.Z.2
  • 30
    • 0025339237 scopus 로고
    • A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations
    • Cupples CG, Cabrera M, Cruz C, Miller JH (1990) A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations. Genetics 125: 275-280.
    • (1990) Genetics , vol.125 , pp. 275-280
    • Cupples, C.G.1    Cabrera, M.2    Cruz, C.3    Miller, J.H.4
  • 31
    • 0031782930 scopus 로고    scopus 로고
    • Formation of 8-oxoguanine in cellular DNA of Escherichia coli strains defective in different antioxidant defences
    • Alhama J, Ruiz-Laguna J, Rodriguez-Ariza A, Toribio F, Lopez-Barea J, et al. (1998) Formation of 8-oxoguanine in cellular DNA of Escherichia coli strains defective in different antioxidant defences. Mutagenesis 13: 589-594.
    • (1998) Mutagenesis , vol.13 , pp. 589-594
    • Alhama, J.1    Ruiz-Laguna, J.2    Rodriguez-Ariza, A.3    Toribio, F.4    Lopez-Barea, J.5
  • 32
    • 63849248363 scopus 로고    scopus 로고
    • The GO system prevents ROSinduced mutagenesis and killing in Pseudomonas aeruginosa
    • Sanders LH, Sudhakaran J, Sutton MD (2009) The GO system prevents ROSinduced mutagenesis and killing in Pseudomonas aeruginosa. FEMS Microbiol Lett 294: 89-96.
    • (2009) FEMS Microbiol Lett , vol.294 , pp. 89-96
    • Sanders, L.H.1    Sudhakaran, J.2    Sutton, M.D.3
  • 33
    • 0023192484 scopus 로고
    • Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide
    • Imlay JA, Linn S (1987) Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide. J Bacteriol 169: 2967-2976.
    • (1987) J Bacteriol , vol.169 , pp. 2967-2976
    • Imlay, J.A.1    Linn, S.2
  • 34
    • 0034641929 scopus 로고    scopus 로고
    • The population genetics of ecological specialization in evolving Escherichia coli populations
    • Cooper VS, Lenski RE (2000) The population genetics of ecological specialization in evolving Escherichia coli populations. Nature 407: 736-739.
    • (2000) Nature , vol.407 , pp. 736-739
    • Cooper, V.S.1    Lenski, R.E.2
  • 36
    • 0034703744 scopus 로고    scopus 로고
    • Evolutionary implications of the frequent horizontal transfer of mismatch repair genes
    • Denamur E, Lecointre G, Darlu P, Tenaillon O, Acquaviva C, et al. (2000) Evolutionary implications of the frequent horizontal transfer of mismatch repair genes. Cell 103: 711-721.
    • (2000) Cell , vol.103 , pp. 711-721
    • Denamur, E.1    Lecointre, G.2    Darlu, P.3    Tenaillon, O.4    Acquaviva, C.5
  • 37
    • 0035114380 scopus 로고    scopus 로고
    • Phylogenetic evidence for horizontal transfer of mutS alleles among naturally occurring Escherichia coli strains
    • Brown EW, LeClerc JE, Li B, Payne WL, Cebula TA (2001) Phylogenetic evidence for horizontal transfer of mutS alleles among naturally occurring Escherichia coli strains. J Bacteriol 183: 1631-1644.
    • (2001) J Bacteriol , vol.183 , pp. 1631-1644
    • Brown, E.W.1    Leclerc, J.E.2    Li, B.3    Payne, W.L.4    Cebula, T.A.5
  • 38
    • 0027169584 scopus 로고
    • Mutants of Escherichia coli with increased fidelity of DNA replication
    • Fijalkowska IJ, Dunn RL, Schaaper RM (1993) Mutants of Escherichia coli with increased fidelity of DNA replication. Genetics 134: 1023-1030.
    • (1993) Genetics , vol.134 , pp. 1023-1030
    • Fijalkowska, I.J.1    Dunn, R.L.2    Schaaper, R.M.3
  • 39
    • 0027323808 scopus 로고
    • The mutational specificity of two Escherichia coli dnaE antimutator alleles as determined from lacI mutation spectra
    • Schaaper RM (1993) The mutational specificity of two Escherichia coli dnaE antimutator alleles as determined from lacI mutation spectra. Genetics 134: 1031 1038.
    • (1993) Genetics , vol.134 , pp. 1031-1038
    • Schaaper, R.M.1
  • 40
    • 0030067883 scopus 로고    scopus 로고
    • Suppressors of Escherichia coli mutT: Antimutators for DNA replication errors
    • Schaaper RM (1996) Suppressors of Escherichia coli mutT: antimutators for DNA replication errors. Mutat Res 350: 17-23.
    • (1996) Mutat Res , vol.350 , pp. 17-23
    • Schaaper, R.M.1
  • 41
    • 28444484984 scopus 로고    scopus 로고
    • Genomic buffering mitigates the effects of deleterious mutations in bacteria
    • Maisnier-Patin S, Roth JR, Fredriksson A, Nystrom T, Berg OG, et al. (2005) Genomic buffering mitigates the effects of deleterious mutations in bacteria. Nat Genet 37: 1376-1379.
    • (2005) Nat Genet , vol.37 , pp. 1376-1379
    • Maisnier-Patin, S.1    Roth, J.R.2    Fredriksson, A.3    Nystrom, T.4    Berg, O.G.5
  • 42
    • 3142628359 scopus 로고    scopus 로고
    • Identification of mutator genes and mutational pathways in Escherichia coli using a multicopy cloning approach
    • Yang H, Wolff E, Kim M, Diep A, Miller JH (2004) Identification of mutator genes and mutational pathways in Escherichia coli using a multicopy cloning approach. Mol Microbiol 53: 283-295.
    • (2004) Mol Microbiol , vol.53 , pp. 283-295
    • Yang, H.1    Wolff, E.2    Kim, M.3    Diep, A.4    Miller, J.H.5
  • 43
    • 29144523534 scopus 로고    scopus 로고
    • A human transporter protein that mediates the final excretion step for toxic organic cations
    • Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, et al. (2005) A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A 102: 17923-17928.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17923-17928
    • Otsuka, M.1    Matsumoto, T.2    Morimoto, R.3    Arioka, S.4    Omote, H.5
  • 44
    • 0035185526 scopus 로고    scopus 로고
    • A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron
    • Miyamae S, Ueda O, Yoshimura F, Hwang J, Tanaka Y, et al. (2001) A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron. Antimicrob Agents Chemother 45: 3341-3346.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 3341-3346
    • Miyamae, S.1    Ueda, O.2    Yoshimura, F.3    Hwang, J.4    Tanaka, Y.5
  • 45
    • 0022381352 scopus 로고
    • Rapid repeated cloning of mutant lac repressor genes
    • Schaaper RM, Danforth BN, Glickman BW (1985) Rapid repeated cloning of mutant lac repressor genes. Gene 39: 181-189.
    • (1985) Gene , vol.39 , pp. 181-189
    • Schaaper, R.M.1    Danforth, B.N.2    Glickman, B.W.3
  • 46
    • 31544450286 scopus 로고    scopus 로고
    • Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: The Keio collection
    • Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, et al. (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol 2: 2006 0008.
    • (2006) Mol Syst Biol , vol.2 , Issue.2006 , pp. 0008
    • Baba, T.1    Ara, T.2    Hasegawa, M.3    Takai, Y.4    Okumura, Y.5
  • 47
    • 0032742730 scopus 로고    scopus 로고
    • A novel role for Escherichia coli endonuclease VIII in prevention of spontaneous G.T transversions
    • Blaisdell JO, Hatahet Z, Wallace SS (1999) A novel role for Escherichia coli endonuclease VIII in prevention of spontaneous G.T transversions. J Bacteriol 181: 6396-6402.
    • (1999) J Bacteriol , vol.181 , pp. 6396-6402
    • Blaisdell, J.O.1    Hatahet, Z.2    Wallace, S.S.3
  • 49
    • 34547442035 scopus 로고    scopus 로고
    • The frequency and structure of recombinant products is determined by the cellular level of MutL
    • Elez M, Radman M, Matic I (2007) The frequency and structure of recombinant products is determined by the cellular level of MutL. Proc Natl Acad Sci U S A 104: 8935-8940.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 8935-8940
    • Elez, M.1    Radman, M.2    Matic, I.3
  • 51
    • 0021333110 scopus 로고
    • In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac bacteriophage containing a plasmid replicon
    • Groisman EA, Castilho BA, Casadaban MJ (1984) In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac bacteriophage containing a plasmid replicon. Proc Natl Acad Sci U S A 81: 1480-1483.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 1480-1483
    • Groisman, E.A.1    Castilho, B.A.2    Casadaban, M.J.3
  • 52
    • 0030597967 scopus 로고    scopus 로고
    • A modified Luria-Delbruck fluctuation assay for estimating and comparing mutation rates
    • Crane GJ, Thomas SM, Jones ME (1996) A modified Luria-Delbruck fluctuation assay for estimating and comparing mutation rates. Mutat Res 354: 171-182.
    • (1996) Mutat Res , vol.354 , pp. 171-182
    • Crane, G.J.1    Thomas, S.M.2    Jones, M.E.3
  • 53
    • 0017180055 scopus 로고
    • Regulation of the regulatory gene for the arabinose pathway, araC
    • Casadaban MJ (1976) Regulation of the regulatory gene for the arabinose pathway, araC. J Mol Biol 104: 557-566.
    • (1976) J Mol Biol , vol.104 , pp. 557-566
    • Casadaban, M.J.1
  • 54
    • 0023132366 scopus 로고
    • In vivo DNA cloning with a mini-Mu replicon cosmid and a helper lambda phage
    • Groisman EA, Casadaban MJ (1987) In vivo DNA cloning with a mini-Mu replicon cosmid and a helper lambda phage. Gene 51: 77-84.
    • (1987) Gene , vol.51 , pp. 77-84
    • Groisman, E.A.1    Casadaban, M.J.2
  • 55
    • 0034612342 scopus 로고    scopus 로고
    • One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
    • Datsenko KA, Wanner BL (2000) One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci U S A 97: 6640-6645.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6640-6645
    • Datsenko, K.A.1    Wanner, B.L.2


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