Comparison of artificial sebum with human and hamster sebum samples

International Journal of Pharmaceutics

Volumn 367, Issue 1-2, 2009, Pages 37-43

  Lu, Guang Wei ^a   Valiveti, Satyanarayana ^a   Spence, Julie ^a   Zhuang, Christine ^a   Robosky, Lora ^a   Wade, Kimberly ^a   Love, Ann ^a   Hu, Lain Yen ^a   Pole, David ^a   Mollan, Matt ^a  

^a PFIZER INC   (United States)

Author keywords

Artificial sebum; Diffusion; Hamster sebum; Human sebum; Partition

Indexed keywords

BENZOIC ACID DERIVATIVE; BUTYL PARABEN; ETHYL PARABEN; HEXYL 4 HYDROXYBENZOATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; HAIR FOLLICLE; HUMAN; HUMAN TISSUE; MALE; MELTING POINT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SEBUM;

ADMINISTRATION, CUTANEOUS; ANIMALS; BIOLOGICAL TRANSPORT; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; DRUG DELIVERY SYSTEMS; HAIR FOLLICLE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; SEBUM; SPECIES SPECIFICITY;

EID: 58249112861     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.09.025     Document Type: Article

References (23)

1. Agarwal R., Katare O.P., and Vyas S.P. The pilosebaceous unit: a pivotal route for topical drug delivery. Methods Find. Exp. Clin. Pharmacol. 22 (2000) 129-133
2. Bertolino A.P., Klein L.M., and Freedberg IM. Biology of hair follicles. In: Fitzpatrick T.B., Eisen A.Z., Wolff K., Freedberg I.M., and Austen K.F. (Eds). Dermatology in General Medicine. 4th edition (1993), McGraw-Hill, New York 289-291
3. Brind J.L., Alani E., Wheatley V.R., and Orentreich N. Analysis of ear sebum of Syrian hamster (Mesocricetus auratus) reveals pronounced sexual dimorphism. Comp. Biochem. Physiol. 84B (1986) 403-407
4. Friberg S.E., and Osborne D.W. Interaction of a model skin surface lipid with a modified triglyceride. JAOCS, J. Am. Oil Chem. Soc. 63 (1986) 123-126
5. Grams Y.Y., Whitehead L., Cornwell P., and Bouwstra J.A. Time and depth resolved visualization of the diffusion of a lipophilic dye into the hair follicle of fresh unfixed human scalp skin. J. Control. Release 98 (2004) 367-378
6. Greene R.S., Downing D.T., Pochi P.E., and Strauss J.S. Anatomical variation in the amount and composition of human skin surface lipid. J. Invest. Dermatol. 54 (1970) 240-247
7. Lademann J., Otberg N., Richter H., Weigman H.J., Lindemann U., Schaefer H., and Sterry W. Investigation of follicular penetration of topically applied substances. Skin Pharmacol. Appl. Skin Physiol. 14 (2001) 17-22
8. Lauer A.C., Lieb L.M., Ramachandran C., Flynn G.L., and Weiner N.D. Transfollicular drug delivery. Pharm. Res. 12 (1995) 179-186
9. Meidan V.M., Bonner M.C., and Michniak B. Transfollicular drug delivery-is it a reality?. Int. J. Pharm. 306 (2005) 1-14
10. Motwani M.R., Rhein L.D., and Zatz J.L. Influence of vehicles on the phase transitions of model sebum. J. Cosmet. Sci. 53 (2002) 35-42
11. Nordstrom K.M., Labows J.N., McGinley K.J., and Leyden J.J. Characterization of wax esters, triglycerides, and free fatty acids of follicular casts. J. Invest. Dermatol. 86 (1986) 700-705
12. Robosky L.C., Wade K., Woolson D., Baker J.D., Manning M.L., Gage D.A., and Reily M.D. Quantitative evaluation of sebum lipid components with nuclear magnetic resonance. J. Lipid Res. 49 (2008) 686-692
13. Rosenthal M.L. In: Libowe I., and Wells F.V. (Eds). Cosmetics and the Skin (1964), Reinhold Publishing Corporation
14. Schaefer H., and Redelmeier T.E. Skin Barrier: Principles of Percutaneous Absorption (1996), Karger, Basel
15. Scheuplein R.J. Mechanism of percutaneous absorption II. J. Invest. Dermatol. 48 (1967) 79-88
16. Spangler W., Gilbert, Roga R.C., Cross, and Henry D. Detergency test based on rapid aging of unremoved sebum. J. Am. Oil Chem. Soc. 44 (1967) 728-732
17. Stefaniak A.B., and Harvey C.J. Dissolution of materials in artificial skin surface film lipids. Toxicol. In Vitro 20 (2006) 1265-1283
18. Stewart M.E., Downing D.T., Pochi P.E., and Strauss J.S. The fatty acids of human sebaceous gland phosphatidylcholone. Biochim. Biophys. Acta 529 (1978) 380-386
19. Strauss J.S., Pochi P.E., and Downing D.T. The sebaceous gland: twenty years of progress. J. Invest. Dermatol. 67 (1976) 90-97
20. Valiveti S., and Lu G.W. Diffusion properties of model compounds in artificial sebum. Int. J. Pharm. 345 (2007) 88-94
21. Valiveti S., Wesley J., and Lu G.W. Investigation of drug partition property in the artificial sebum. Int. J. Pharm. 346 (2008) 10-16
22. Wertz P. Table 2. Lipid composition of human sebum. The structure and function of skin. In: Walters K.A., and Roberts M.S. (Eds). Dermatological and Transdermal Formulations (2002), Marcel Dekker, New York p. 14
23. Williams M.L., and Elias P.M. The extra cellular matrix of stratum corneum. Role of lipids in normal and pathological functions. Crit. Rev. Ther. Drug Carrier Syst. 3 (1987) 95-122